Francesca Manza

“But bread causes my symptoms…” 🍞🤔 How should clinicians approach this common consultation? In @FrontGastro_BMJ, this practical piece explores possible clinical scenarios behind bread-related symptoms — from coeliac disease to wheat allergy, IBS, FODMAP sensitivity and beyond. 🔎🩺 A useful read for turning a familiar patient concern into a structured, evidence-based conversation. Read more: fg.bmj.com/content/early/… #CoeliacDisease #IBS #FODMAPs #Nutrition #GutBrainAxis #FrontlineGastro #GItwitter #Gastroenterology #ClinicalPractice #PatientCentredCare @mnz_francesca @shefgastro @BritSocGastro @my_UEG @AmCollegeGastro @DDWMeeting @ESGE_news @PhilSmithIsBack @OTavabie @dr_aditi_kumar @TrevorTabone @eathar_s @IrenePerezMD @KGananandan @zare_benjamin @medicalreg @dtleiberman

Read the new #GUTBlog by Dr Mohamed Shiha @Mo_Shiha and Dr Francesca Manza @mnz_francesca on the paper published in the March issue of @Gut_BMJ entitled "Global prevalence of self-reported non-coeliac gluten and wheat sensitivity: a systematic review and meta-analysis" via bit.ly/4bNU2xS Paper accessed via bit.ly/4rOWMjj @shefgastro #NCGWS

Read the new #GUTBlog by Dr Mohamed Sinha @Mo_Shiha and Dr Francesca Manza @mnz_francesca on the paper published in the March issue of @Gut_BMJ entitled "Global prevalence of self-reported non-coeliac gluten and wheat sensitivity: a systematic review and meta-analysis" via bit.ly/4bNU2xS Paper accessed via bit.ly/4rOWMjj @shefgastro #NCGWS

🥨 🥐 ‘But bread causes my symptoms’: possible clinical scenarios 🍞 🫚 Read this fantastic review paper by Francesca Manza and co-authors! 🍞 Wheat components can induce reactions in a number of people. ⚛️ Gluten is the known trigger in coeliac disease, mediated by human leucocyte antigen-DQ2/DQ8 and adaptive and innate immune responses. 🫚 Wheat allergy involves immunoglobulin E-mediated reactions to specific wheat proteins such as gliadins, lipid transfer proteins and albumins. WHAT THIS STUDY ADDS Non-coeliac gluten/wheat sensitivity is often overlapping with irritable bowel syndrome as it presents with shared intestinal and extraintestinal symptoms but lacks clear biomarkers, making diagnosis reliant on exclusion and food challenges. HOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICY Diagnosis of wheat-related disorders can be challenging in a clinical setting and requires a stepwise approach. fg.bmj.com/content/early/… @PhilSmithIsBack @OTavabie @dr_aditi_kumar @TrevorTabone @eathar_s @IrenePerezMD @KGananandan @zare_benjamin @medicalreg @dtleiberman #wheat #gluten #coeliacdisease #celiacdisease #glutenfree #foodallergy #foodintolerance #autoimmunedisease #gastroenterology #digestivehealth #guthealth #ibd #gihealth #nutrition #malabsorption

My co-authors and I are pleased to share that our article, “Non-Celiac Gluten/Wheat Sensitivity—State of the Art: A Five-Year Narrative Review”, has been selected as an Editor’s Choice Article mdpi.com/2072-6643/17/2…

Promoting Well‐Being Among Gastroenterologists – A Call for Systemic Action - Zimmermann - United European Gastroenterology Journal - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/ue… @UEGJournal @my_ueg

🌾 Recent findings indicate that 10% of people worldwide self-report non-celiac gluten or wheat sensitivity. But gluten may not always be to blame for symptoms of this poorly understood condition. #GlutenFree ja.ma/4nZPCXd

New Insights on Gluten Sensitivity jamanetwork.com/journals/jama/… Delighted to share this quick update published on #JAMAnetwork on our newly published meta-analysis on the prevalence of non-coeliac gluten sensitivity, led by my friend and colleague @Mo_Shiha

Global prevalence of self-reported non-coeliac gluten and wheat sensitivity: a systematic review and meta-analysis gut.bmj.com/content/early/…

Delighted to share our latest study published today @Gut_BMJ 🌍 >49,000 participants from 16 countries 🌾 One in ten people worldwide report sensitivity to gluten/wheat 🧠 Significant association with anxiety, depression and IBS @mnz_francesca 👉 bit.ly/4nlJW9C

🚨 Our new randomised trial is out in @AnnalsofIM We found that a Mediterranean diet 🥗 is noninferior and even superior to traditional dietary advice for managing IBS symptoms. 💡 The Mediterranean diet is a viable first-line dietary therapy for IBS shorturl.at/dQWnz

🥗 Mediterranean diet beats standard advice for IBS In a UK RCT, 62% of IBS patients improved on the Mediterranean diet vs 42% with traditional dietary advice — showing superiority and noninferiority. 👉 1st-line option beyond low-FODMAP. pubmed.ncbi.nlm.nih.gov/41144975/ #GITwitter

Great talks by Dr. @Mo_Shiha and Dr. Imran Aziz at UEGW on IBS and bile acid diarrhoea @my_ueg #UEGWeek #uegw2025

🆕 The 2025 European guidelines for the diagnosis of coeliac disease No-biopsy diagnostic option for the first time in adults with suspected coeliac disease Published today @UEGJournal onlinelibrary.wiley.com/doi/10.1002/ue…

🌾 Presenting today: Beyond Coeliac Disease: the science and the controversy of gluten sensitivity @foodallergy4um in Amsterdam! Thanks for the opportunity!

Burnout in gastroenterology is real, it is common, and the time to address it is now. @mnz_francesca @UEGJournal @my_ueg onlinelibrary.wiley.com/doi/10.1002/ue…

🌾Trends in non-coeliac gluten/wheat sensitivity: a self-managed problem? Click the link below to read the full text! tandfonline.com/doi/full/10.10…

Important study by Dr Imran Aziz and the team demonstrating the rise in #DGBIs since #COVID19Pandemic Are health care sevices able to manage patient need? @AGA_CGH @RomeFoundation @ShefUni_ClinMed @DrPalssonUNC Read @ bit.ly/4g3zhye