
Mosasaurus (revived)
1.4K posts

Mosasaurus (revived)
@mosasaurus27
Studying molecular interactions



The Origin of Species was published in 1859. Principia Mathematica was published in 1687, two centuries earlier. Conceptually, it seems like natural selection is much simpler than the theory of gravity. So why did it take two centuries longer to discover? A contemporary of Darwin's, Thomas Huxley, read the Origin of Species and said, “How extremely stupid not to have thought of that!” Nobody ever said the same for not beating Newton to the Principia. I wonder if the reason this happened is that Darwin’s cannot be decisively tested. The evidence is circumstantial, retrospective, and cumulative. There's no equivalent of Newton running the numbers on the moon's orbital period and radius, and confirming that it corresponds to his theory. In fact, nearly two thousand years before Darwin, the Roman poet Lucretius argued in De Rerum Natura that organisms suited to their environment survive while ill-adapted ones perish. But nobody built a science on it. Without a tight verification loop, the idea just floated by. Terence Tao argues that Darwin succeeded where Lucretius failed because he had the ability to convince people that the gaps in his theory (specifically, what is the mechanism of heredity) would be filled. This was less about ‘hard’ scientific insight, and more a matter of having good research taste and being persuasive. But it was crucial for progress in biology.

When Copernicus proposed heliocentrism in 1543, it was actually less accurate than Ptolemy's geocentric model - a system refined over 1,400 years with epicycles precisely tuned to match observed planetary positions. It took another 70 years before Kepler, working from Tycho Brahe's unprecedentedly precise observations, replaced Copernicus’s circles with ellipses - finally making heliocentrism empirically superior. Terence Tao's point is that science needs a high temperature setting. If we only fund and follow what's most state of the art today, we kill the ideas that might need decades of work to surpass some overall plateau.






happy two year anniversary to owlposting.com it is simultaneously the highest-EV and also worst thing ive ever started in my life. the pro of online writing is that ive made a lot of friends due to it, and the con is that the psychic tax of maintaining it is bizarrely high for what ostensibly is a little essay every few weeks. i strongly suspect that nobody who regularly writes online has a baseline emotion state that is envious. if i had to do it all over again, im not sure i would, but im still happy i did. it's kind of like having an extremely annoying child



Reasons to be pessimistic (and optimistic) on the future of biosecurity owlposting.com/p/reasons-to-b… "It was such a fun read (if you can say that about an article on weapons)!" —a glowing review from an early reader this is (once again) the longest article I have ever published at 13,000 words. it involves interviews with 16+ researchers/VC's/policy folks in this field, and discusses basically every single facet of biosecurity that i could find. topics include: how machine-learning in rapid response therapeutic design may work, the financial status of the customer base of biosecurity startups, why agroterrorism feels extremely likely to me, and a lot more i admittedly started the essay pessimistic that this subject matters at all, and i end it surprised that it doesn't keep more people awake at night. im not a doomer about it all, but i can see how people become one. very grateful to the people who decide to spend their career (or some fraction of it) working here, and especially grateful to the ones who helped teach me about the subject
