Mosasaurus (revived)

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Mosasaurus (revived)

Mosasaurus (revived)

@mosasaurus27

Studying molecular interactions

Oxford, England Katılım Mart 2020
919 Takip Edilen156 Takipçiler
Mosasaurus (revived)
Mosasaurus (revived)@mosasaurus27·
@genologos I think the premise of his statement, that - natural selection is conceptually simpler thus why did we not discover it earlier - is wrong.
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Mike White
Mike White@genologos·
“Circumstantial” is an odd term to choose. Most of reality can’t be accessed directly by human senses and thus scientists often test ideas using something other than direct observation. Atoms were accepted by most physicists based on “circumstantial” evidence
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Mike White
Mike White@genologos·
The science of evolution continues to be widely misunderstood. This is egregiously wrong - about how natural selection has been tested and about how scientific theories in general are tested:
Mike White tweet media
Dwarkesh Patel@dwarkesh_sp

The Origin of Species was published in 1859. Principia Mathematica was published in 1687, two centuries earlier. Conceptually, it seems like natural selection is much simpler than the theory of gravity. So why did it take two centuries longer to discover? A contemporary of Darwin's, Thomas Huxley, read the Origin of Species and said, “How extremely stupid not to have thought of that!” Nobody ever said the same for not beating Newton to the Principia. I wonder if the reason this happened is that Darwin’s cannot be decisively tested. The evidence is circumstantial, retrospective, and cumulative. There's no equivalent of Newton running the numbers on the moon's orbital period and radius, and confirming that it corresponds to his theory. In fact, nearly two thousand years before Darwin, the Roman poet Lucretius argued in De Rerum Natura that organisms suited to their environment survive while ill-adapted ones perish. But nobody built a science on it. Without a tight verification loop, the idea just floated by. Terence Tao argues that Darwin succeeded where Lucretius failed because he had the ability to convince people that the gaps in his theory (specifically, what is the mechanism of heredity) would be filled. This was less about ‘hard’ scientific insight, and more a matter of having good research taste and being persuasive. But it was crucial for progress in biology.

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Mosasaurus (revived)
Mosasaurus (revived)@mosasaurus27·
But let’s suppose they had, both of them had no understanding at the time of what the mechanism of inheritance was, only that phenotypes can be predicted in some form by looking at the parents. They would have to wait for a few more years before arriving at DNA
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Mosasaurus (revived)
Mosasaurus (revived)@mosasaurus27·
Funnily enough, Mendels work would have been a major support for Darwin’s theory. Unfortunately they never crossed paths, at to my knowledge, and Mendels work was only appreciated much later on.
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Mosasaurus (revived)
Mosasaurus (revived)@mosasaurus27·
@owl_posting article on Biosecurity was fascinating! I was wondering if any of the field specialists you spoke to mentioned any concerns regarding mirror proteins
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Mosasaurus (revived)
Mosasaurus (revived)@mosasaurus27·
Perhaps we should find a way to accurately mimic the cellular crowding state
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Mosasaurus (revived)
Mosasaurus (revived)@mosasaurus27·
So then you end up with having to crank up the salt to prevent aggregates or misfolding, all the while you are wondering how does this happen inside the cell
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Mosasaurus (revived)
Mosasaurus (revived)@mosasaurus27·
Something underdeveloped in lab protocols are buffers, by far. Especially in protein purification protocols. They do a very poor job at capitulating the actual cellular environment that these proteins exist in. We make an attempt to, but never deal with crowding
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Mosasaurus (revived) retweetledi
Soham Sankaran
Soham Sankaran@sohamsankaran·
Abhi's writing is both eerily timely and surprisingly timeless. Owl Posting is rapidly becoming part of the modern canon of science writing. May it last and last -- 2 more years, and 20 more after that!
owl@owl_posting

happy two year anniversary to owlposting.com it is simultaneously the highest-EV and also worst thing ive ever started in my life. the pro of online writing is that ive made a lot of friends due to it, and the con is that the psychic tax of maintaining it is bizarrely high for what ostensibly is a little essay every few weeks. i strongly suspect that nobody who regularly writes online has a baseline emotion state that is envious. if i had to do it all over again, im not sure i would, but im still happy i did. it's kind of like having an extremely annoying child

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Mosasaurus (revived)
Mosasaurus (revived)@mosasaurus27·
@OliviaHelenS @mkoeris Imo, majority of biosecurity threats are posed by states as opposed to small organizations/individual actors. And I’m also not sure if they are aimed at harming human health
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Mosasaurus (revived)
Mosasaurus (revived)@mosasaurus27·
@OliviaHelenS @mkoeris Say you were able to do this as well. Obtaining sufficient titres of this would also be difficult! For individual actors, it seems like there are much easier ways to inflict terror
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Olivia H. Scharfman
Olivia H. Scharfman@OliviaHelenS·
This is a well-researched article, and I highly encourage everyone to read it. But its final conclusions are unfounded. (1/n)
owl@owl_posting

Reasons to be pessimistic (and optimistic) on the future of biosecurity owlposting.com/p/reasons-to-b… "It was such a fun read (if you can say that about an article on weapons)!" —a glowing review from an early reader this is (once again) the longest article I have ever published at 13,000 words. it involves interviews with 16+ researchers/VC's/policy folks in this field, and discusses basically every single facet of biosecurity that i could find. topics include: how machine-learning in rapid response therapeutic design may work, the financial status of the customer base of biosecurity startups, why agroterrorism feels extremely likely to me, and a lot more i admittedly started the essay pessimistic that this subject matters at all, and i end it surprised that it doesn't keep more people awake at night. im not a doomer about it all, but i can see how people become one. very grateful to the people who decide to spend their career (or some fraction of it) working here, and especially grateful to the ones who helped teach me about the subject

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