adic

reminder that I have severe long COVID and if I seem whiny or stupid it’s probably because I’m in a bad flare, please don’t update down too much

@Ruesavatar I don’t really use crush tho Moreso infatuation, flirting, fascination, attraction

Ok, I am curious. What does the word “crush” invoke for you? As in the context of romantic interest, don’t be sassy. For me it is the stage between realizing mutual interest/attraction and defining the relationship. So we talk, we flirt, but haven’t yet made things official.

@AdvancedTweaker @MelRoBuilds they’re all pretty well evidenced for their given indications and if you’re old and fogged your priorities are different I think there are better options for a lot of those but if not overdosed they’re not irresponsible

@adic_9 @MelRoBuilds Honestly I feel like 1) a scary amount of meds and 2) anything that has clear psychiatric side effects doesn't sit well with me. I'd probably feel frustrated, angry, and scared too if someone close to me got pushed into taking all that. Just my feelings though.

I have a new mortal enemy One of the Boomers' docs put 'em on the death panel when I wasnt looking. (T4 monotherapy, statin, beta blocker, l-dopa, + multiple 'memory' drugs) Im ready to call out the firing squad

@michael_hoerger In SF we have far UVC in our public spaces 🙌

I stand in a room w/70 people, 70 masked. HVAC & air purifiers humming, CO2 <700ppm. Not in San Francisco, where COVlD is surging, but in the Deep South. Levels are much lower. It's a place too many east/west coast "liberals" look down on. Lead, follow, or get out of the way.

@gymrat_bookworm @PostcookedMusic It’s hit or miss ime Some people benefit from aspirin I personally feel awful but I have a leukotriene mutation

@adic_9 @PostcookedMusic COX 1 inhibitors are are apparently awful for MCAS, So that limits many NSAIDs!

"I'm not like the other girls." -Fluvoxamine Classifying Fluvoxamine as an "SSRI" is going to limit its use in the Long COVID community due to lack of acceptability, "I am not depressed." and/or "I have had bad reactions to other SSRIs in the past." What is compelling and intriguing about this drug is it's dual action of serving as a potent anti-inflammatory, neuroprotective sigma 1 agonist. Sigma 1 agonists do everything you need them to do--reduce oxidative stress/neuroinflammation while promoting neuroplasticity through increasing the availability of Brain-Derived Neurotrophic Factor (BDNF). You want to know what else serves as a potent sigma 1 agonist? DMT. I have not trialed this drug in my Long COVID journey, but as I've mentioned many times over, inhibiting the COX-2 pathway via Celebrex was an overnight game changer for me in terms of managing brain fog. It's interesting to see COX-2 mentioned in this proposed mechanism. A lot of talk about histamine, but you do not want to forget about prostaglandins, either!

@PostcookedMusic @gymrat_bookworm Celecoxib is most selective, its great. Iirc naproxen is a bit better than ibuprofen. Many NSAIDs to choose from.

@adic_9 @gymrat_bookworm There's other options for COX2 as well, but you don't want to completely selectively inhibit it, it's necessary for Kidney function. Ibuprofen is highly highly selective for it, which is why long-term use causes Kidney issues

@divisionish Gut stuff probably

@adic_9 I've started to notice that nearly every RX and many OTC will affect serotonin in some way. Wonder if that's by design or accident

Just a heads up famotidine isnt recommended for people who get migraines

@orphcorp Everything Is Metabolic

this framing of some ADHD presentations as energetic dysregulation tracks with several things we are anecdotally or correlatively seeing re: mitochondrial, metabolic, and inflammatory function in adhd individuals the proposed cycle is ~ energetic strain -> compensatory stimulation or effort -> temporary stability -> greater cumulative cost -> performance collapse "Within EDHD, executive processes are metabolically contingent and state-dependent, particularly vulnerable within prefrontal networks, while hyperactivity, impulsiveness, and attentional variability are conceptualized as transient, probabilistic compensatory responses to energetic strain rather than primary pathology"

@frausteinbock @gymrat_bookworm you can have an AI do it but it’s a bit annoying. I did a couple for friends on my workstation but don’t have energy to do more, if I do again I’ll try to remember to reach out

@adic_9 @gymrat_bookworm How can I do this? Is there an app for this or with AI? 🙏

Scrolled past this Sjorgen's diagram and I'm like, "not another EBV activation x HLA group bullshit thing that is hard to diagnose!!"

@DiamonDie @divisionish Interesting. Definitely some weird stuff going on.

@adic_9 @divisionish Famotidine on its own causes me migraines. Famotidine + H1 blocker has never done this (though also does not do anything beneficial I can notice).

@divisionish it does do some weird serotonin stuff tho, i wouldnt avoid it until proven a trigger

@divisionish theres no causality data and correlation is overdetermined given the relationship between estrogen-histamine-migraines

@i2cjak If ur in SF there’s a really good regen dentist who knows about all the good modern tech

I need to get my teeth fixed. Idk why I don’t go to the fucking dentist I have dental and money. I guess I’m afraid.

@goblinodds ty I kind of want to wait for tooth tech to get good bc rn it’s a lot of pain and flare for an impermanent pretty shitty solution but ugh may take a while

@adic_9 !! gl !!!

so ive had ENT issues since uh forever? have always sounded like im suffering from a mild cold (it was actually really bad when i was a little kid--got loads of ear infections and started failing hearing tests so they took out my tonsils and adenoids when i was around 4 or 5)

@IanCSU You try withdrawing from a benzo-like substance every month on sensitized receptors and not taking anything for it

@IanCSU better to take like 3 half doses a month than for every interaction with the world to do psychological damage every month

can confirm that various combinations of: - cetirizine - loratadine - famotadine (even at half doses) completely eliminate the late luteal irritability + sense that the world is better without me very quickly after taking them It works yall!!!

@goblinodds Not in the near future. Still holding out hope that fixing teeth stuff will fix sinus stuff

@adic_9 damn !! wait are u planning to get sinus surgery