Michelle R. Zimmerman, PhD #MIEExpert #LongCovid

Day 1,831. A new treatment. It’s been used post stroke, TBI, concussion, & athletes. They are going to start me two times a week. They had me try to talk at the same time, and it provoked speech issues & nystagmus, where I couldn’t control eye movements. vestibulartrainingservices.com/web/index.php?…

Dr. Kirk Milhoan (@KMilhoanMDPhD) reacts to a federal judge pausing ACIP’s work, and we examine real patient stories and how public health should respond to vaccine injuries with Dr. Craig Spencer (@Craig_A_Spencer) & Dr. Akiko Iwasaki (@VirusesImmunity): podcasts.apple.com/us/podcast/aci…

Letter from Congressman Pete Stauber on Long COVID research and support of our research and upcoming clinical trial at U of Arizona and Geisinger (We have permission from the Congressman to share this letter) Thank you @RepPeteStauber 🙏🏾

Pediatric long COVID is characterized by myeloid CCR6 suppression and immune dysregulation Very interesting Spanish study in preprint! #LEONARDI_effect in CHILDREN! ➡️Chemokine receptor CCR6 on the surface of myeloid cells, which include monocytes, macrophages, and dendritic cells, play a key-role in the innate immune system. ➡️Now this study shows CCR6 expression on myeloid cells are SURPRESSED and serves as the most discriminative biomarker for pediatric long COVID, reflecting profound immune dysregulation, including altered innate immunity, lymphocyte overactivation, and impaired SARS-CoV-2 humoral responses, that persists months after acute infection in affected children and adolescents. ➡️This study is highly relevant as one of the first to identify suppressed CCR6 expression on myeloid cells as a strong, discriminative biomarker (79% accuracy) for pediatric long COVID, shedding light on persistent immune dysregulation in children and filling a critical gap in understanding its mechanisms compared to adults. ➡️What this likely means biologically: - The reduced CCR6 on myeloid cells points to a form of innate immune dysregulation persisting months after the initial infection. - It could impair the proper migration or function of these cells to resolve inflammation, contribute to ongoing low-grade immune activation/misbalance (e.g., altered dendritic cell/monocyte subsets observed in the study), or reflect broader exhaustion/altered signalling in the myeloid compartment. - This ties into the study's overall picture of dysregulated innate immunity combined with overactive lymphocytes and weaker antibody responses in affected kids, suggesting myeloid changes (like CCR6 downregulation) as a core driver of why some children develop prolonged symptoms. ‼️Early claims that SARS-CoV-2 poses essentially no harm to children were dangerously oversimplified and wrong, the virus does cause real, sometimes severe or prolonged damage in kids, including acute complications like MIS-C, rare but tragic deaths, and persistent long COVID in a substantial group, with now measurable immune dysregulation that can impair development and quality of life, maybe even life-long! Makes me ANGRY, very ANGRY! FYI: @fitterhappierAJ insight.jci.org/articles/view/…

@renesugar 21 is a very small number. I have a larger number of us with negative results, and not the same genetic markers identified. It is the same argument trying to attribute all problems to genetic variants without looking at and acknowledging counter examples.

In utero #COVID exposure linked to brain changes, developmental delays, anxiety, and depression At 2 years, 14% of toddlers in the prepandemic group were at high risk for developmental delays, compared with 51.6% in the COVID-19 group. cidrap.umn.edu/covid-19/utero…

Scientists say they now know what went wrong with Johnson & Johnson’s Covid vaccine | The Independent independent.co.uk/news/health/jo…

A massive study of 40,537 people in @ScienceDirect just redefined C0VID as "a condition of long-lasting immune compromise." 20 months post-infection, T-cells & NK cells (our primary viral & cancer defense) had NOT recovered. So much for "It's mild." sciencedirect.com/science/articl… 🧵1