Apratim (Appy)

@City_Chief Not even an Arsenal fan but this is childish lol

Currently my favorite video from the lab... Mapping of blood vessels and nerves in whole embryos of rhesus macaque. They form scale-free fractals of dimensions 3 and 2, independently of development stage. More here: biorxiv.org/content/10.648…

Beautiful

Our chromatin dynamics paper is now in @NatureSMB with important updates. We tracked chromatin in additional cell lines (5 overall), from the shortest timescales accessible today, over 6-7 orders of magnitude in time (MINFLUX + camera-based tracking) nature.com/articles/s4159…

Interesting model

Search is full of ads and wrong answers. Every other email is an ad. Prime Video charges you and shows ads. Paramount? Ads. Peacock? YouTube? Hulu? Ads followed by more ads. Netflix full of ads. Meta and X, every other thing is an ad. Pinterest is nothing but ads. AI is in everything. AI finishes sentences incorrectly and won’t stop. AI reads your email and search history to target you with more ads. Every time you open an app or visit a site there’s an update making it worse. In a hurry? First, click here to agree to terms you don’t have time to read and must accept. You need an account to do that. Change your temporary password. Enter your 2FA code. Check your email and enter that code. Now use a passkey. Your password is too simple to remember. Change it. No, not like that. Now log on. Enter your 2FA code. Check your email for a code… Welcome back! We’ve updated our terms of service and privacy policy (you have none). Subscribe to the site. Subscribe to Netflix. Subscribe to toilet paper. Subscribe to these groceries. Pay a membership fee for the right to subscribe then tip your driver who delivers the subscriptions your membership lets you subscribe to. Time to work? We’ve got to update your laptop and will slow down everything you do until you agree to update. But first, click here to agree. Update installed — your laptop’s broken now. It doesn’t matter, since your boss just replaced you with AI. Go to your phone to complain on social media. Wait, your phone needs an update so we can add more AI. Click here. Oh sorry, your phone can’t handle this update. Now it’s useless. Go get the newest phone. Here’s a text from a friend, an email, a voice mail they left three days ago but you didn’t see until now because of sync problems with the cloud. It’s their GoFundMe. Their MLM. Their Patreon. Never mind, you didn’t respond to their text within 9 minutes and now you’re no longer friends. They blocked you. Make new friends. Download this app to find people in your area. In your neighborhood. On your street. Two doors down from you. Do you know this person yet, we think you’d get along. You need an account to use this app. That username is taken. Enter a password. Not that one, you used it on another site. You need to be connected to WiFi to download the app. Allow the app to connect to other devices on your network. Allow the app to access your contacts, know your precise location, store your credit card details. Oops, sorry, we got hacked now all that info is available on the web. There’s a class action suit. You can join. It’ll take a decade to get your $3.73 share of the ten billion settlement. We’ll send it via PayPal or deposit it to your bank, just tell us those details. Oh no, another hack. That info is circulating now, too. Here’s a spam call, a spam email, a spam text. Why are you angry? Why are you talking about getting rid of your phone? Why don’t you like AI, it lets us make all of this easier? Do you know how ridiculous that sounds? This is progress. You’ll be left behind. Do you want to be left behind? Do you???

For decades, biology textbooks have enshrined a simple rule: DNA is made by copying a template. After one enzyme unzips a DNA double helix into separate strands, another called a polymerase builds a complementary sequence, base by base, for each strand. Presto: two copies of the original DNA. But new research into how bacteria defend themselves from viruses now shows this synthesis rule isn’t absolute. Now, a team describes a bacterial enzyme that synthesizes DNA without a nucleic acid template, using its own structure as a guide. Learn more: scim.ag/4tTc5IA @NewsfromScience

Only one chance in this lifetime… Like watching sunset at the beach from the most foreign seat in the cosmos, I couldn’t resist a cell phone video of Earthset. You can hear the shutter on the Nikon as @Astro_Christina is hammering away on 3-shot brackets and capturing those exceptional Earthset photos through the 400mm lens. @AstroVicGlover was in window 3 watching with @Astro_Jeremy next to him. I could barely see the Moon through the docking hatch window but the iPhone was the perfect size to catch the view…this is uncropped, uncut with 8x zoom which is quite comparable to the view of the human eye. Enjoy.

The highest quality video of the moon was just released… this is so beautiful.

ft. @mukherja, @MustafaMir16 (@PennCDB), Manya Kapoor (@pennbioeng), Kareena Shankta, @littlescholar_, @GHaywardLara, @ratchasp, Yara Haloush (@CHOP_CCGM) & @raymonddcarter (@BMBGGUPENN) @PennEpiInst @CHOP_Research @hhmi_science nature.com/articles/s4146…

3D imaging reveals that the size and composition of pancreatic islets underlie their loss in type 1 diabetes 📹 Alexandra Rippa et al, Diabetes Institute, College of Medicine, University of Florida in @NatureComms ➡️ bpod.org.uk/archive/2026/3… with @DrJohnAnkers

@arjunrajlab Phenomenal movie. Phenomenal analogy 🫡

Side point: when I first watched Memento, I thought: dang, Lenny is clueless. But more recently, I've been thinking, we are all Lenny, we just don't even realize it.

If you are new to agentic coding, watch the movie Memento, then have someone explain agentic coding to you using the movie as a metaphor. Like "Your CLAUDE.md file is like Lenny's tattoos" and so on. Plus, it's a great movie.

More details can be found in our bluesky post: bsky.app/profile/mirlab… Thank you to everyone who has been part of this incredible effort and to the scientific community for their engaged discussions throughout the process!

Super excited that our paper on RNA Pol II clustering and kinetics in live embryos is finally out in print! We find that RNAPII clusters represent stoichiometric accumulations of molecules with a single cluster stably associated with a single gene (1/2) nature.com/articles/s4146…

@LocasaleLab I feel like you’re always complaining about academia 😅 What’s something that you would say you still very much admire about academia?

This reflects how science has been packaged and evaluated over the past two decades. In the 2000s figure preparation software such as PowerPoint and Illustrator became straightforward to use. By the early 2010s, high-impact journals came to associate dense, elaborate figures (i.e. the exhibits of a scientific study) with rigor and depth. The implicit assumption was that more panels and more data reflected more thorough and careful work. At the same time, the editorial decision on whether to proceed to peer review was made by individuals not deeply embedded in the specific science, relying more on visual presentation and the perceived completeness of the data. The aesthetics of the figure panels became a proxy for scientific thoroughness. In response, scientists adapted. Figures became more complex, more densely populated, and more expansive in scope. This gave the appearance of rigor independent of whether the additional data materially clarified the central questions of the study. Reviewers were tasked with evaluating these large and complex datasets under significant time constraints, typically within a few days and without compensation, while managing substantial professional responsibilities. Under these conditions, it is impossible to systematically interrogate every component of a multi-panel figure. There is also a reluctance to question whether key elements of a study are missing if there is a possibility they are included somewhere within the large amount of presented data. The result is a publication system in which the presentation of large volumes of data in complex figure formats can facilitate publication in high-profile journals, often with limited connection to the underlying clarity, coherence, or quality of the science itself.

Our findings, together with labs @renkawitzteam, @BenediktSabass, combining immunology, mechanobiology and parasitology are in Biorxiv doi:doi.org. 10.1101/2024.05.03.592378. Congratulations to first author Mauricio Fernandez-Ruiz.

@DanThomasESPN For Shaka - what would a goalkeeper prefer first? A simple cross that he comes and claims or a diving stop to tip the ball past the goal after the defence was split open?

Any questions for Shaka, Stevie, Mario or Kieran?

@DanThomasESPN For Stevie and Mario - what are some of the specific tactical differences between playing in a back 3 vs back 4? How easy is it to switch mid-game?

We’ve trained a multimodal AI model to turn routine pathology slides into spatial proteomics, with the potential to reduce time and cost while expanding access to cancer care.

機能を保ったまま生きた脳組織の透明化を実現した論文がNature Methods誌に掲載されました。 2013年に固定組織の透明化法を発表した当初、「いつか生きたまま透明にできますか？」という質問を幾度となくされて、常にNoと答えていたのですが、ついに実現しました！ nature.com/articles/s4159…