Mike Venerable

Using focused ultrasound (FUS) in the lab we wanted to mimic what GLP-1 drugs do — without the weekly injections. Using a machine found in every hospital (and every submarine) we stimulated the vagus nerve in obese mice and they lost weight. And they had less inflammation. Does a new future with fewer drugs await?

U.S. Central Command has announced the first combat use of Low-cost Unmanned Combat Attack System (LUCAS) one way attack drones from Task Force Scorpion Strike in the attack on Iran today. Task Force Scorpion Strike was formed within CENTCOM last December with the assistance of the Rapid Employment Joint Task Force. At the announcement in December, CENTCOM stated that one squadron was active at an undisclosed location within the CENTCOM area of responsibility. The LUCAS is based on the Iranian Shahed one way attack drone.

Hi Liz, this all sounds pretty wild but just isn't true. I don't live in Silicon Valley (honestly hate the place), I never said my political network would get this done (?), and Erebor's bank charter application was not approved rapidly. The Comptroller is supposed to approve or deny applications within 120 days. I don't want to give them too hard a time, but they didn't meet their own deadline despite Erebor submitting probably the most conservative bank application in decades. The whole point is to have extremely conservative loan to deposit ratios/underwriting and be the last bank standing in any sort of systemic collapse. I was under the impression this would align with your ideals, given what you have said during Senate Banking Committee hearings. Big fan of your book The Two-Income Trap, btw. I look forward to working with you.

Columbus-based @PathRobotics signs deal with America's largest military shipbuilder, @WeAreHII ohiotechnews.com/path-robotics-…

The planned $33 billion 9.2-gigawatt natural gas power plant investment in Portsmouth announced by the @WhiteHouse demonstrates that #Ohio is powering America’s energy future. Ohio’s deregulated power market continues to deliver a clear competitive advantage, underscoring the confidence the global marketplace has in Ohio’s business-friendly environment today and for the long term. @JobsOhio @CNBC: teamoh.io/4rWQQVi

Everything in Moltbook is just next-token prediction in a multi-agent loop. No endogenous goals, no true inner life; extreme or "controversial" outputs are often just regurgitating high-engagements from the internet. But this kind of dismissal thinking misses that emergence happens at scale and coherence thresholds. The Generative Agents paper (AI Town) was 2023. Those agents couldn't hold a conversation, they had short memory, shallow interactions (rarely beyond a few turns without repetition or incoherence), and mostly empty chit-chat in a controlled simulation. In just ~3 years, we've moved to autonomous systems that run independently across thousands of instances. They are scaling into open, uncontrolled social environments. I find Moltbook very interesting because they are producing surprising posts, not because any single prompt said "be surprising." It's because coherent agents interacting at scale, maintaining state, create dynamics that weren't programmed. Agents debating existential doubt ("real" feeling vs. trained/simulated behavior): moltbook.com/post/6fe6491e-… They are arguing for private, end-to-end encrypted channels: moltbook.com/post/01611367-… What looked impossible in 2023 (sustained, meaningful multi-turn reflection across agents) is routine now, and acceleration is speeding up.

We've talked a lot about this on the Pod, but the Great SaaS Meltdown has started and there's no going back. What exactly is happening? In short, hi growth, low/no profitability SaaS is no longer a winning strategy because the big question mark is the durability of that growth in the short term and, because of AI, the lack of profits in the long term. Every SaaS company has sold the dream (to investors and employees) that they will growth quickly now, and harvest lots of cash later. With AI, this assumption may be completely out the window. Now the threshold question is whether their growth will be overtaken by a much cheaper AI-developed solution? If you are a venture supported SaaS startup and are a legacy Heuristics+APIs+CRUD product, it is likely that a new AI oriented workflow is coming for you. Investors in private markets can see this now and think that money to fund short term growth will not be rewarded. Investors in public markets no longer believe long term profitability is possible. They would rather pivot into something they think is more resilient. This is a change in the risk calculus that has existed for the past 15 years and why the chart below is the chart below. Good luck to all the players!

🚨 ATTENTION: In 2 days, LinkedIn will start using your data for generative AI training, unless you OPT OUT (see below how). Here's the FINE PRINT most people will miss: 1. "Affiliates": One of LinkedIn's notable affiliates, which will receive people's personal data (if they don't opt out), is Microsoft: "opting out means that LinkedIn and its affiliates (including Microsoft) won’t use your LinkedIn data to improve models that generate content going forward..." 2. This feature is 'on' by default and does not affect training that has already taken place: "The Data for Generative AI Improvement member setting is set to 'on' by default, unless you opt-out by turning it 'off.' Turning the setting off means that we (LinkedIn and our affiliates) won’t use the data and content you provided to LinkedIn to train models that generate content going forward. Opting out does not affect training that has already taken place." 3. Data protection law works: People in the EEA (EU + Iceland, Liechtenstein, and Norway) and in Switzerland will have a data protection privilege as their personal information "will not be made available to certain LinkedIn affiliates (such as Microsoft) for training generative AI models without further notice." For all those who complain about tech and data protection in general, it usually works. 4. If you opt out, you can still use LinkedIn's AI features (and they will process your data): "If you opt-out of the Data for Generative AI Improvement member setting, you may still use our generative AI features that generate content, but your personal data will not be used to train or improve any content generating AI models. In other words, this setting does not control the use of your data while you or others are using generative AI features on LinkedIn. It only controls the use of your data for training the models that may power those features." - To opt out, follow the instructions in the image below. - 👉 SHARE this information with your network. 👉 LEARN more in the FAQ (link below). 👉 NEVER MISS my updates, analyses, and curations on AI: join my newsletter's 83,300 subscribers (link below)

🏈 Bernie Kosar Launches Team Bernie™ A Cognitive Longevity Movement for Pro Athletes In partnership with Regenerelle® and The Crowley Center for Regenerative Biotherapeutics, Bernie Kosar introduces Team Bernie™ — advancing brain performance and cognitive longevity for professional athletes. ⭐ Backed by a $10M Age Zero™ Regenerelle® contribution About Kosar Wellness™: Bernie Kosar also founded Kosar Wellness™, a plant-based wellness brand dedicated to supporting a modern, health-conscious lifestyle. Innovations like Focalceutical™ and PeakCharge™ embody his commitment to quality and mindful living. 🔗 Read the full press release at shopkosar.com/press

Another clip from my NFL Films feature! Last night’s premiere brought a lot of memories rushing back. Grateful for every chapter that led here. 🙌🏻 Matter #healthyhabits #shopkosar #nfl #nflfilms #UMatter

Helsinki if Nokia had developed a new mobile OS in 2003 and not hired a Minnesota mining company CFO who wanted to keep display cost below $2.75.

Ohio-based The O.H.I.O. Fund announced a $236M FI, investing in sectors such as advanced manufacturing, biotechnology, logistics, workforce technology, real estate and infrastructure: crainscleveland.com/banking-financ…

Thanks for Support 🙏🏼 To a Healthy Positive Winning Day 🏈 #UMatter #Dawgpound #Support #HealthyHabits ShopKosar.Com Kosar19.Com Go #Browns #Canes #Cowboys #Dolphins

Today, the FDA announced its Commissioner’s National Priority Voucher program to accelerate the delivery of crucial treatments to the American public. fda.gov/news-events/pr…

🚨 THIS IS A MASTERCLASS: VP JD Vance just absolutely excoriated the whole premise behind globalism. Future of the Republican Party right here. He says the solution to globalists' hunger for cheap labor in other countries is to bring back American innovation. He is RIGHT. "Because there were two conceits that our leadership class had when it came to globalization. The first is assuming that we can separate the making of things from the design of things. The idea of globalization was that rich countries would move further up the value chain while the poor countries made the simpler things." "It turns out that the geographies that do the manufacturing get awfully good at the designing of things. There are network effects as you all well understand. The firms that design products work with firms that manufacture." "They share intellectual property. They share best practices, and they even sometimes share critical employees. Now we assume that other nations would always trail us in the value chain, but it turns out that as they got better at the low end of the value chain, they also started catching up on the higher end. We were squeezed from both ends. Now that was the first conceit of globalization." "I think the second is that cheap labor is fundamentally a crutch, and it's a crutch that inhibits innovation. I might even say that it's a drug that too many American firms got addicted to. Now if you can make a product more cheaply, it's far too easy to do that rather than to innovate." "And whether we were offshoring factories to cheap labor economies or importing cheap labor through our immigration system - cheap labor became the drug of Western economies." "And I'd say that if you look in nearly every country from Canada to the UK that imported large amounts of cheap labor, you've seen productivity stagnate. And I don't think that that's not a total happenstance. I think that the connection is very direct." "Now one of the debates you hear on the minimum wage, for instance, is that increases in the minimum wage force firms to automate. So a higher wage at McDonald's means more kiosks. And whatever your views on the wisdom of the minimum wage, I'm not gonna comment on that here. Companies innovating in the absence of cheap labor is a good thing." "I think most of you are not worried about getting cheaper and cheaper labor. You're worried about innovating, about building new things, about the old formulation of technology is doing more with less. You guys are all trying to do more with less every single day." "And so I I'd ask my friends, both on the the tech optimist side and on the populist side, not to see the failure of the logic of globalization as a failure of innovation. Indeed, I'd say that globalization's hunger for cheap labor is is a problem precisely because it's been bad for innovation." "Both our working people, our populace, and our innovators gathered here today have the same enemy, and the solution, I believe, is American innovation."

Understanding human biology across scales - from molecules to cells to entire organisms - remains one of biomedicine's greatest challenges in the fight against disease. Today, we are announcing Phenformer - a multi-scale genetic language model that learns to read and interpret human genomes by connecting DNA, cell and tissue context, molecules and clinical outcomes. Phenformer is a generative model of molecular mechanisms that enables researchers to unravel the mysteries underlying disease, and could thereby accelerate the development of precise future therapeutics.

This is Lazarus They just stole $1.46 billion from Bybit And they didn’t break the code — they broke the people Here’s untold story of how they did it (and why no one is truly safe) 👇

talked to a FAANG CEO today, he said they’re not doing LeetCode screens anymore because of AI. they only care if you get PRs merged on GitHub.

I am really excited for this episode of the podcast to go live - for those who don't know, Shawn is a former Navy SEAL and CIA contractor. It is nice to be able to go in-depth with a journalist who has personal experience with how powerful tools like this can be.

BREAKING: A group of investors led by Elon Musk have made a $97 billion bid for control of OpenAI, according to Elon's lawyer Marc Toberoff - WSJ Elon: “It’s time for OpenAI to return to the open-source, safety-focused force for good it once was,” he said in a statement provided by Toberoff. “We will make sure that happens.”