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The only way is up! Use @nanopore for all your modification needs with no additional sample prep required. All these models are now available in Dorado. #nanoporeconf
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Nathan 🧬
291 posts
Nathan 🧬
@nathanbaggers
Sequencing Chemistry Research Scientist @nanopore Views are my own
Katılım Ocak 2012
52 Takip Edilen181 Takipçiler
Nathan 🧬 retweetledi
🚨 We’re hiring ! 🚨
Join our cutting-edge research team as a molecular biologist at @nanopore HQ in Oxford.
Perfect for a fresh PhD or MSc with a couple of years’ experience. Work at the interface of chemistry, molecular/synthetic biology and AI
👉 ejnh.fa.em2.oraclecloud.com/hcmUI/Candidat…
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Nathan 🧬 retweetledi
.@nanopore CEO Looks Beyond Native DNA, RNA Sequencing
“I don’t think proteomics will win over genomics," Sanghera said. "They go hand-in-glove. We’ve been overly focused [on genomics], and now we’re going to see an emergence of proteomics...
hubs.li/Q034jCDL0
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Nathan 🧬 retweetledi
We have been busing working on research models to detect all 2'Ome-RNA modified nucleotides on top of PseudoU, m6A, m5C and Inosine using @nanopore dRNA seq.
Preliminary results on Human #rRNA are very exciting. See🦋for more details bsky.app/profile/adrien…
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Excited about @nanopore's collaboration with @uk_biobank to create the first comprehensive epigenetic map of the human genome. Thrilled to see work from our team (@Stoibs11, @AdrienLeger2, @ArtRand ) driving such pivotal advancements!
Oxford Nanopore@nanopore
We are proud to announce a collaboration with @uk_biobank to create the world’s first large-scale #epigenetic dataset of 50k participants. The dataset will unlock crucial insights into how #epigenetics drives disease & the breakthroughs to treat them. bit.ly/4g34RuK
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Nathan 🧬 retweetledi
Today a landmark genetics partnership between @UK_Biobank, @nanopore, @SciTechgovuk, @GenomicsEngland and @NHSEngland to better understand the root causes of cancer and dementia has been announced.
Find out more: ukbiobank.ac.uk/learn-more-abo…
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Nathan 🧬 retweetledi
It's Christmas in advance with a very special @nanopore #opendata release ! 🎅
Today we are releasing our 5mC 5hmC and 6mA DNA mod synthetic control datasets with each mods in all possible 5 mers contexts. All nicely wrapped in a comprehensive validation blog post.🎁
Marcus Stoiber@Stoibs11
New blog: Modified Base Best Practices & Benchmarking for @nanopore 🧬 sequencing Includes: * Raw POD5 files for synthetic ground truth strands * Modified base calling best practices * Modkit recommendations Check it out: labs.epi2me.io/mod-validation… #methylation #bioinformatics
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An exciting new chapter for @nanopore
Oxford Nanopore@nanopore
.@nanopore today announced that @RosemaryDokos has been appointed Chief Product & Marketing Officer & Lakmal Jayasinghe as Chief Scientific Officer, effective immediately. Rosemary & Lakmal succeeded Clive Brown as Chief Officer of Technology, Innovation, & Products. Read more: bit.ly/3O4ulvQ
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Nathan 🧬 retweetledi
Discover how you can obtain ultra-rich #singlecell #transcriptome data without compromise. Catch our demo at #ASHG24 to learn how @nanopore's unrestricted read length spans full-length transcripts, providing new insights into single cells.
Learn more: bit.ly/4hzzaLe
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Nathan 🧬 retweetledi
🧬 Do you want to learn how to use @nanopore sequencing to detect DNA base modifications?
Our new course will include experimental design with important considerations for generating ultra-long #Nanopore #sequencing reads.
👇 Register your interest:
okt.to/x1YZuT
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Nathan 🧬 retweetledi
The study nicely illustrates how @nanopore overcomes Illumina's errors, which often arise from difficulties aligning reads in repetitive (left) and variant-dense regions (right). "The work thus heralds a new era, in which Illumina short-read sequencing no longer rules supreme."
Aaron Pomerantz, PhD@AaronPomerantz
“This important study shows how a combination of the latest generation of @nanopore long reads with state-of-the art variant callers enables bacterial variant discovery at an accuracy that matches or exceeds the current "gold standard" with short reads” elifesciences.org/articles/98300
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Nathan 🧬 retweetledi
🆕 Registration has just opened for this two-day comprehensive course, learning how to use @nanopore #sequencing to detect DNA base modifications.
🗓️ 04 - 05 February 2025
📍 Online (via Zoom)
➡️ okt.to/QrGMKT
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Nathan 🧬 retweetledi
Nathan 🧬 retweetledi
T2T assembly kit. Incredibly powerful potential with this data.
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Nathan 🧬 retweetledi
Updates to Direct RNA
-RNA004 accuracy: 98.9%
-Short-read RNA sequencing (>50 nts)
-Accurately basecall four modifications: m6A, m5C, pseudouridine, and inosine.
#nanoporeconf
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Nathan 🧬 retweetledi
@nanopore Addition of m5C and inosine modified basecallers to m6A and pseU enables expanded view of RNA biology
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FOUR modified RNA bases read out in one command with the latest Dorado release. Enabling so much greater exploration of RNA biology! #NanoporeConf
Chris Seymour@iiSeymour
Dorado v0.8.0 #ncm24 release! - v5.0 DNA transformer model performance improved for A100/H100 via kernel fusing, quantisation and leveraging i8 tensor cores. - v5.1 RNA models with updated mod calling for m6A, pseU, and brand new calling of Inosine and m5C. - Improved dorado correct performance, stability and flexibility. - Introduces per-barcode configuration for poly(A) estimation with interrupted tails. #nanoporeconf github.com/nanoporetech/d…
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I am looking forward to giving a talk at @EarlhamInst for #EIInnovate 2024. I'll be discussing how our collaboration between @nanopore and @EarlhamInst has been transformative in delivering impact, with a specific focus on mod bases. #newmodmodel
earlham.ac.uk/events/ei-inno…
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Nathan 🧬 retweetledi
Introducing ElysION: Oxford Nanopore's sample-to-answer sequencing solution.
Learn more: nanoporetech.com/products/prepa…
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Nathan 🧬 retweetledi
.@jeffnivala & team at @UW unveiled a groundbreaking ‘proof-of-concept’ method showcasing the capability of #nanopore sequencing to read #polypeptide stands — a major step forward in protein analysis.
Learn more: lnkd.in/emzmFUzQ
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