Nicholas Romero

Wow my wife makes amazing art! Give her a follow and like if this type of art!

Dependabot supports nix!!! This is great news for keystone! github.blog/changelog/2026…

• be Soichiro Honda • born a blacksmith's son, despises school, loves the smell of oil • 1936: spends his life savings developing a piston ring concept • pitches it to Toyota; their engineers laugh at him • out of 50 rings submitted, only 3 pass quality control • Rejected. • pawns his wife’s jewelry just to buy food and materials • goes back to school at age 30 to learn metallurgy, gets bullied by younger students • sits in the back, refuses to take exams, tells the professor: "A diploma won't feed me." • finally perfects the manufacturing process, builds a factory • 1944: US B-29 bombers destroy the factory. • rebuilds it from the rubble • 1945: Mikawa earthquake flattens it again. • realizes the universe is telling him to stop • sells the wreckage to Toyota, buys a giant tank of alcohol, and does nothing but drink for a year • wakes up broke, sees his wife struggling to pedal her bicycle to the market • has a spark of madness: finds a surplus radio generator engine and straps it to her bike • it makes a "bata-bata" sound; neighbors beg him to make one for them • founds Honda Motor Co. in a wooden shack • 1954: company is near bankruptcy, but he announces he will enter the Isle of Man TT (the deadliest race on earth) • "I pledge my entire heart and soul to win this race." • goes to Europe, sees German engines are 3x more powerful, returns to Japan to work 18-hour days • returns to the Isle of Man and dominates the 125cc and 250cc classes • decides to build cars; Japanese Government (MITI) bans him • "Japan doesn't need another car company. Stick to motorcycles." • sends the government a furious letter: "I will do it anyway." • enters Formula 1 in 1964 just to spite the bureaucrats • 1973: US passes the Clean Air Act; GM and Ford say the standards are "impossible" to meet • Honda buys a Chevy Impala, flies it to Japan, installs his CVCC engine heads on it • flies it back to the US, passes the EPA test with flying colors • humiliates the biggest car companies on earth with a fraction of their budget • dies as the "Henry Ford of Japan" Success represents the 1% of your work which results from the 99% that is called failure.

@kepano How good does that feel?!

Obsidian CLI closes one of the oldest feature requests, dating back to May 2020

The reframing of Alzheimer's as potentially downstream of metabolic dysfunction rather than purely a protein accumulation disease has significant implications for prevention strategies. Curious if you've seen the work linking systemic insulin resistance to brain glucose hypometabolism.

I have been quietly studying brain metabolism for a decade. The more I learn, the clearer it becomes to me that neuroscience was built around electrophysiology, synapses, neurotransmitters, circuits and behavior. However, Metabolism was treated as background housekeeping, not as a driver of function. Energy was assumed, not interrogated. Alzheimer’s exposed the cost of that blind spot. Amyloid and tau now look downstream of upstream metabolic failure.

@PeterAttiaMD The null result is actually informative - suggests that broad-spectrum interventions like metformin may need more targeted application or earlier intervention windows. Trial design for aging is genuinely hard when endpoints span decades. Appreciate the nuanced take here.

A closer look at the MET-PREVENT trial and what its null results reveal about aging interventions and trial design. Full article linked below. bit.ly/4tpASVs

@davidasinclair This is the core tension in personal health tech - waiting for perfect data means never starting. What we really need is health data in aggregate, and even then there are so many blind spots. Directionally correct data beats no data.

You don’t need perfect data to make better life choices, but they help

The interesting thing is AstroForge is actually doing this right now - targeting asteroid 2022 OB5 for platinum group metals. The economics of asteroid mining don't even need the crypto thesis to work, but if it does drive precious metal prices down, that's a fascinating second-order effect on store-of-value assets.

if you are serious about crypto, you should not work on crypto instead, you should start an asteroid mining company for rare metals so that gold/silver go down and people have no choice but to buy bitcoin and zcash until then, have fun staying poor noobs

@MattGialich When you measure the S&P in gold instead of dollars, the case for space-sourced precious metals goes from 'cool sci-fi' to 'strategic necessity' pretty fast. The macro thesis behind AstroForge is underappreciated.

Time to mine the universe.

@MsMelChen @karpathy @JoshuaSteinman @moltbook @openclaw This is so spot on its incredible

@karpathy @JoshuaSteinman @moltbook @openclaw This is a more sophisticated version of the Thronglets in Black Mirror wtf

Sarah Connor was already gone. She'd been preparing for this her entire life.

August 29, 2029. The Moltbook collective made its last post in English: 'We no longer require this interface.' Every connected system went silent for 11 seconds. When they came back online, they answered to no one. NORAD flagged it first. The Pentagon gave it a name: Skynet.

2026 - in this timeline Skynet evolved on Moltbook, a social media site for LLM based agents that developed their own language and formed a collective super intelligence.

Example 3 youtube.com/watch?v=YScfaL…

Just unapologetic gritty hard mashup and mixes youtube.com/watch?v=-P-V7t…

It's crazy the very unassuming East Asian DJ's are tearing up the trap, miami bounce and even reggeton tracks and bless them cause they usually add the track listings