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What is the UK Dementia Research Institute (UK DRI)? youtu.be/rUi5teM7C20 via @YouTube
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@Neurosharp
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@Neurosharp
@Neurosharp
Neuroscientist, Neurologist, Dad, & Network enthusiast - Director of Care Research & Technology Centre, UK Dementia Research Institute
Prof. Imperial & DRI Katılım Haziran 2010
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@Neurosharp retweetledi
Many congratulations to @IngaKoerte and Nikolaus Plesnila for an excellent @ENONeurotrauma meeting. Great fun, great hospitality and great scientific programme.
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@Neurosharp retweetledi
Can’t believe it’s been a week since our launch of Friend’s of the Care Research & Technology Centre (Friend’s of CR&T), fantastic event bringing together those interested in being at the heart of our research, find out more 👉 imperial.ac.uk/uk-dri-care-re…
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@Neurosharp retweetledi
Really interesting! Although traumatic brain injury (TBI) is associated with ⬆️ Alzheimer's risk and ⬆️ phospho-tau181, this study shows phospho-tau181 is not elevated in the first year after moderate-to-severe TBI
jnnp.bmj.com/content/early/…
@nsngraham, @jmschott, @neurosharp
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@Neurosharp retweetledi
Fantastic to speak at this years @UKDRI Connectome event about…well….me. Really enjoyed speaking about my path, the wheel of skills and working in the grey (where the magic happens). Finding out about my panel members was an amazing bonus!
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@Neurosharp retweetledi
Super interesting review from @sj_marzi on the application of AI and machine learning in experimental medicine for dementia research👩💻👩🔬🧠
Read more in @alzdemjournals👉buff.ly/3PzcVb8
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@Neurosharp retweetledi
No big deal - solanezumab targeted soluble monomers the idea being to pull amyloid out of the brain like a sponge - but it didn’t clear amyloid. I really don’t understand why the company pursued it so long I would have dropped years ago (easy to say now)
Danielle Beckman@DaniBeckman
Bad news in #Alzheimer research.. #solanezumab, a drug targeting monomeric amyloid-β species, did not slow cognitive decline in patients with preclinical Alzheimer's in a large cohort of patients. nejm.org/doi/full/10.10…
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@Neurosharp retweetledi
Pleased to see this comment with @Neurosharp published looking at the great work of the TRACK TBI team on dynamic patient trajectories years post-injury.
More to be done to understand things at a mechanistic level but key implications for patient monitoring & treatment trials.
Nat Rev Neurology@NatRevNeurol
New online! Clinical outcomes evolve years after traumatic brain injury dlvr.it/Sw0fB8
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@Neurosharp retweetledi
Acetylcholine modulates the temporal dynamics of human theta oscillations during memory
nature.com/articles/s4146…
#neuroscience
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@Neurosharp retweetledi
This month's @Brain1878 contains a set of important articles on #Parkinsons and #LewyBody dementia, including reviews on alpha-synuclein and bradykinesia, papers on cholinergic loss, mechanisms underlying rigidity, impulse control disorder and cognition academic.oup.com/brain/issue
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@Neurosharp retweetledi
So much respect for @englandcricket and @CricketAus for raising awareness of dementia in such a powerful way (and for entertaining us with such wonderful cricket all through this Ashes series)
England's Barmy Army 🏴🎺@TheBarmyArmy
This was quite the gesture ❤️ The England team wore different shirts to highlight the confusion caused by dementia.
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@Neurosharp retweetledi
By analysing videos of concussions in professional American football games and modelling the impacts, Zimmerman et al. show that loss of consciousness is associated with deformation in brainstem regions containing nuclei involved in arousal. tinyurl.com/2s4kp6x6
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@Neurosharp retweetledi
Interesting study need more like this please looking at dementia risk factors. Frustratingly ambiguous findings (primary outcome solidly negative) further targeted trial work needed for hearing aids, but some suggestive benefits in high risk subgroups. More biomarkers/ diagnoses?
The Lancet@TheLancet
#AAIC23 While hearing aids did not have an impact on cognitive decline over 3 years in a general population, treating hearing loss protected against cognitive decline in older adults at greater risk of dementia, finds a new trial: hubs.li/Q01XYp_M0
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@Neurosharp retweetledi
Dr Giovanna Lalli, the UK DRI's Director of Scientific Affairs, is @BritishNeuro's Face of the Fortnight!🙌
Stay tuned to BNA's feed to hear from Giovanna over the next couple of weeks.
Find out more👉buff.ly/3K6Rz2H
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@Neurosharp retweetledi
Fantastic to hear from our incoming Director, Prof Siddharthan Chandran, at the Dementia Mission event at #AAIC23 yesterday!
Prof Chandran discussed the important role the UK DRI can play in the Mission - both in discovery research and translation👏
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@Neurosharp retweetledi
Terrific news today as results from phase 3 trial of #Alzheimers drug donanemab presented at #AAIC23 confirm the drug significantly reduced amyloid in the brain & slowed disease progression👏 🧠
UK DRI researchers comment on the encouraging results🙌 👉buff.ly/3K0pr1c
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@Neurosharp retweetledi
Fantastic day @ARUKscientist @UCLBrainScience speaking to interested members of the public about our @UKDRI work at the Care Research and Technology Centre @ImperialBrains using and designing technology with, and for, people living with dementia, well done team 🎖️
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@Neurosharp retweetledi
Wu et al. describe the clinical and radiological features of genetic leukoencephalopathies in a large cohort of 309 adults, and find that the most frequently mutated genes are NOTCH3 (25%), NOTCH2NLC (19%), ABCD1 (9%), CSF1R (7%) and HTRA1 (5%). tinyurl.com/y28fhfyp
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