NewLimit

106 posts

NewLimit banner
NewLimit

NewLimit

@newlimit

Working toward radical extension of human healthspan using epigenetic reprogramming.

South San Francisco, CA Katılım Ekim 2021
3 Takip Edilen42.8K Takipçiler
Sabitlenmiş Tweet
NewLimit
NewLimit@newlimit·
Following breakthrough results, we’re bringing longevity medicine to human trials. We’ve raised a $435M Series C led by @foundersfund to make it happen. Reprogramming cell age has the potential to create more healthy years for everyone. We're closer than ever to realizing it.
English
121
424
3.3K
2M
NewLimit retweetledi
Jacob Kimmel
Jacob Kimmel@jacobkimmel·
enjoyed chatting with @SabrinaHalper in the lab (!) a few weeks back rarely do i get to cover whale lifespans, @newlimit, spacefaring human speciation events, & ai therapeutic design in one place
Sabrina Halper@SabrinaHalper

"Aging is the process of a complex system slowly falling into its chaotic disequilibrium. And it's not like evolution necessarily even set a lifespan for us. It is merely the result of, once the system has been established, how long its intrinsic property stayed ordered before it became disordered." I’m excited to share my conversation with @jacobkimmel of @newlimit. Every species who has ever lived has one shared certainty: we’ll age, decay, and die. Jacob and his team are among the small group of people on earth with the expertise and funding to work on this problem. We talked about why we age, whether cellular aging can actually be reversed, how evolution shaped our lifespan and our peaks, and how AI is fundamentally changing the next era of science. Recorded at New Limit’s HQ in South San Francisco. Timestamps: 00:00 Intro 01:25 Why Evolution Limits Lifespan 03:13 Evolution Tradeoffs Explained 07:44 Why Women Live Longer 10:15 Lessons from Long Lived Species 16:20 Peak Intelligence 23:26 What is Aging? 27:59 Yamanaka Factors 32:18 New Limit 33:56 AI's Role in Progress 37:28 Organ by Organ Longevity 40:28 Is Immortality Possible? 42:04 Lifespan Progress 45:44 How to Test Longevity Drugs 49:30 Placebo Mind Body Link 53:56 What longevity hacks actually work? 57:25 Peptides And Stem Cells 01:00:34 Gene Editing 01:05:10 Personalized Medicine 01:08:48 Philosophical Dilemmas of Longer Lifespans 01:14:57 Living Off Earth 01:16:55 AI And Bio Risks

English
3
8
57
8.7K
NewLimit retweetledi
Jacob Kimmel
Jacob Kimmel@jacobkimmel·
this is our most dynamic summer yet @newlimit - 3X data efficiency for reprogramming AI from lineage generalization - >100X manufacturing scale for our lead therapeutic asset - +4 leads that restore function in old hepatocytes, +5 payloads in endothelium & lots more in our blog
Jacob Kimmel tweet media
English
4
8
77
8.9K
NewLimit retweetledi
Brian Armstrong
Brian Armstrong@brian_armstrong·
NewLimit made major progress in the past year toward our mission of radically extending human healthspan. Check out this talk where we run through what we've built, and our vision for where it's going.
Jacob Kimmel@jacobkimmel

every year @newlimit, we host friends at the lab & share our progress for 2026, we announced: - 2X increase in discovery rates with AI systems - new program for endothelial cells - 0 -> 1 medicines headed to the clinic - accelerating recovery from alcohol some highlights --

English
56
53
545
75K
NewLimit retweetledi
Jacob Kimmel
Jacob Kimmel@jacobkimmel·
every year @newlimit, we host friends at the lab & share our progress for 2026, we announced: - 2X increase in discovery rates with AI systems - new program for endothelial cells - 0 -> 1 medicines headed to the clinic - accelerating recovery from alcohol some highlights --
English
21
31
252
251.1K
NewLimit retweetledi
Jacob Kimmel
Jacob Kimmel@jacobkimmel·
in our 2026 @newlimit progress update, we announced our first candidate medicine. it has the one of the most striking effects i’ve ever seen. a single treatment accelerates recovery from alcohol in old animals. it’s so dramatic you can see it with your bare eyes!
English
29
44
402
121.5K
NewLimit
NewLimit@newlimit·
Each year, we share a public update on our progress @newlimit from our lab in South San Francisco. This year, we announced: 1. 2X increase in discovery rates with AI systems 2. New program focused on endothelial cells 3. 0 -> 1 medicines headed to the clinic Full event video below
English
10
29
232
43.3K
NewLimit retweetledi
Brian Armstrong
Brian Armstrong@brian_armstrong·
Imagine you had the energy, metabolism, and mental agility of your younger self - without the aches and pains that come from aging. That’s what we’re attempting to build at @NewLimit and it will be one of the most important achievements in human history ever if it works. We're on the cusp of this being tractable given the rise of AI to test more hypotheses in-silico, along with the rapidly falling cost of single cell sequencing, etc. We announced our Series C and upcoming human clinical trials this week, so still a long, long way to go, with many risks. But with hard work we've got a shot at making this a reality.
English
251
259
2.4K
200.7K
NewLimit retweetledi
Ashlee Vance
Ashlee Vance@ashleevance·
New Limit just raised $435 million. This is, in part, because they've had a massive breakthrough on reversing the age of the liver with their new brand of genetic reprogramming drugs. For the first time, NewLimit's co-founder and president Jacob Kimmel details the company's breakthrough here. We also get into the longevity and bio-tech fields more broadly to explain where aging science and AI are heading. If nothing else, come to see some mice get drunk. The Core Memory podcast is available wherever you pod, and I'll put the YouTube link down below in the replies. Our show is sponsored by Brex and SendCutSend. They are both wise and benevolent. Timestamps 0:00 Intro 3:50 What Is Epigenetic Reprogramming? 7:16 Growing a Whole Animal From One Old Cell 13:06 Meet Ambrosia, the AI Hunting for Youth 22:44 $435 Million and the Race to Human Trials 29:26 The Drunk Mice That Skip the Hangover 36:48 Inside the First Human Trial 43:14 Will There Ever Be a Hangover Pen? 49:39 Beyond the Liver: The Delivery Problem 1:03:27 Answering the Skeptics 1:12:42 Will OpenAI Become a Drug Company? 1:23:53 The Health Story Bigger Than AI? 1:35:00 How Far Behind Is the US vs China? 1:53:10 Can We Build Computers From Neurons?
English
9
30
240
93.7K
NewLimit retweetledi
Andrew Dunn
Andrew Dunn@AndrewE_Dunn·
NewLimit, the anti-aging startup co-founded by Coinbase CEO Brian Armstrong, has closed the 2nd largest round in biotech for 2026: endpoints.news/anti-aging-bio…
English
0
8
125
13.3K
NewLimit retweetledi
Brian Armstrong
Brian Armstrong@brian_armstrong·
Aging is arguably the root cause of most major diseases (loss of function in our cells). Four years ago, we made a bet that aging was treatable, and NewLimit was born. NewLimit now has a prototype drug that reverses the age of some human cells (restores function they had when they were younger), and a clinical trial scheduled for next year (with more drug candidates in the pipeline). Grateful to Founders Fund, Thrive, Greenoaks, and the rest of the investors for this latest round. @jacobkimmel and the team are just getting started.
NewLimit@newlimit

Following breakthrough results, we’re bringing longevity medicine to human trials. We’ve raised a $435M Series C led by @foundersfund to make it happen. Reprogramming cell age has the potential to create more healthy years for everyone. We're closer than ever to realizing it.

English
440
932
9.9K
1.6M
NewLimit retweetledi
Jacob Kimmel
Jacob Kimmel@jacobkimmel·
on day 1 @newlimit, we imagined it would take 10+ years to invent real medicines. our recent results have accelerated the timeline to next year. we've raised a Series C led by @foundersfund alongside @ThriveCapital, @Greenoaks, and many others to bring therapies to the clinic. medicines for aging are among the most valuable possible technologies. we are grateful to our partners for the opportunity to pursue this mission.
NewLimit@newlimit

Following breakthrough results, we’re bringing longevity medicine to human trials. We’ve raised a $435M Series C led by @foundersfund to make it happen. Reprogramming cell age has the potential to create more healthy years for everyone. We're closer than ever to realizing it.

English
67
62
643
98.1K
NewLimit
NewLimit@newlimit·
Following breakthrough results, we’re bringing longevity medicine to human trials. We’ve raised a $435M Series C led by @foundersfund to make it happen. Reprogramming cell age has the potential to create more healthy years for everyone. We're closer than ever to realizing it.
English
121
424
3.3K
2M
NewLimit retweetledi
Dwarkesh Patel
Dwarkesh Patel@dwarkesh_sp·
If animals live longer, they can have more kids, and pass on more of their genes. So why hasn't evolution solved aging? @jacobkimmel explained the three evolutionary reasons why we still grow old: (1) Longevity doesn't actually help that much. Most of our primate ancestors didn't die of natural causes: if you are probably going to be eaten by a tiger, a naturally long lifespan is pointless. (2) Some genes might benefit from aging! If an older animal dies, often the resources they would have consumed are instead consumed by younger kin, who are genetically similar to them but more likely to reproduce. (3) Even if the two other arguments are wrong and there's selection against aging, there might be even stronger selection on other traits. Evolution just might not prioritise longevity.
English
55
39
545
124.7K
NewLimit retweetledi
Jacob Kimmel
Jacob Kimmel@jacobkimmel·
.@newlimit's first reprogramming medicines will enter the clinic in the coming years. we're recruiting a clinical leader to guide these trials for a new class of medicines intended to keep patients healthier, longer. reach out if you or a colleague are a good fit.
Jacob Kimmel tweet media
English
3
14
97
10.7K
NewLimit retweetledi
BiotechTV
BiotechTV@BiotechTV·
𝐄𝐩𝐢𝐠𝐞𝐧𝐞𝐭𝐢𝐜𝐬: BiotechTV visited @newlimit in South San Francisco and heard from Co-Founder & President @jacobkimmel how they are trying to tackle diseases of aging through epigenetic reprogramming.
English
6
12
91
85.2K

Keşfet

@SabrinaHalper @jacobkimmel @byersblake @brian_armstrong @foundersfund @ThriveCapital @Greenoaks @QuietCapital