nextgenseek

The chemistry of next-generation sequencing go.nature.com/46LXALP

Check out this exciting new opening for an Asst/Assoc professor position in Population Genomics in Cornell's Department of Computational Biology! cornell.app.box.com/s/6pawkbu4gahi…

10 tips to set and customize ggplot2's title text cmdlinetips.com/2023/09/tips-t… title/ #rstats

Proud to share our #eGTEx multi-tissue dissection of #enhancer H3K27ac across 387 brain, muscle, heart, and lung samples from #GTEx in @NatureGenet #eQTLs #haQTLs #SexDiffs #Epigenomics #GWAS #linking Paper: nature.com/articles/s4158… (H3K27ac, today) News: csail.mit.edu/news/unlocking… m6A paper: go.nature.com/3qGg3VI (2021) @MIT @MIT_CSAIL @BroadInstitute @MITEECS @MIT_SCC @harvard @harvardmed @GTExPortal

A fun blog w/ a link to slides on the "Novelty/Failure Dilemma" in drug R&D. Do we have to choose between novel targets with transformational potential and programs w/ increased probability of success in clinical development? I don't think so... plengegen.com/blog/bullseye-…

Here, in full directly on Twitter, is "A Hackers' Guide to Language Models". This 90 minute tutorial is designed to be the one place I point coders at when they ask "hey, tell me everything I need to know about LLMs!" It covers both @OpenAI models and open source ones in depth.

Another series of ComplexHeatmap tutorials on YouTube. Thank the author for the contribution! youtu.be/3IsgDG9uS7E?si…

Idea: 2016 Company: 2018 NHP data: 2020 1st patient dosed: 2022 1st human data for in vivo liver base editing in patients with heterozygous familial hypercholesterolemia and ASCVD 👇🏽 @American_Heart @VerveTx $VERV Stay tuned!

Really informative primer from @jmuiuc on large language models in compbio/genomics youtube.com/watch?v=tRTVxl… presented at the @UCLA_CGSI series. This whole series is very useful for anyone interested in computational biology/genomics.

Excited to share our paper by 🌟 @MGHCVFellows @tigerstatdoc creatively applying Bayesian multivariate genetic analyses to lipids to (1) nominate several novel loci, (2) improve polygenic scores, & (3) improve causal gene prioritization sciencedirect.com/science/articl… @iScience_CP

veloVI enhances RNA velocity analysis with uncertainty quantification and extensibility by deep generative modeling of gene-specific transcriptional dynamics. @adamgayoso @PhilippWeiler7 @fabian_theis @YosefLab OA paper: nature.com/articles/s4159…

On October 23, we will submit Seurat v5 to CRAN, and once accepted it will become the default version for new installs. A few notes on v5 below:

Exciting news! #CZCellxGene now has 50M+ unique cells + 915 datasets, providing an even more reference-quality #SingleCell data for you to download & visually explore. Thanks to all the researchers who have contributed their data to cellxgene! bit.ly/3sZynhV

📢 Introducing the Data Science Postdoctoral Fellows Program at Harvard/DFCI! 🔹 Join a research group in our department 🔹 Co-mentoring opportunities with 2+ faculty 🔹 Collaborate with DFCI investigators beyond our department 🔹 Salary starts at $75K ds.dfci.harvard.edu/postdocs/

#scRNAseq is a multimodal assay producing two count matrices: unspliced & spliced counts (e.g. for RNA velocity). Which should be used for clustering? Can they be used together? If so, how? Tara Chari w/ @GorinGennady answer some of these questions in biorxiv.org/content/10.110… 1/🧵

The 1000 Genomes dataset has been the most robust, generally-available imputation reference panel for nearly 10 years now The new HGDP plus 1000 Genomes dataset from @genetisaur et al. seems to have finally de-throned it gencove.com/blog/an-update…

Chatting Apton Acquisition with PacBio CEO Christian Henry omicsomics.blogspot.com/2023/09/chatti…

Take a look at our new work on inferring networks from CRISPR perturbations, a powerful experimental+computational approach for investigating downstream effects of altered gene expression:

It's on! The first of two workshops at #positconf2023 is running 👐 #dataviz #posit #positconf #chicago

First @PacBio MAS-Seq for bulk RNA (Iso-Seq) preprint! Captured full length 7kb RBFOX2 isoforms in Cas13d-mediated knock down biorxiv.org/content/10.110…