Ojore Oka

Our paper on the #UPR transducer, ATF6, is published today in #PNAS. We highlight redox-dependent dimerisation of ATF6 as key regulatory element. Many thanks @BulleidNeil, @Saxy_Scientist, and members of @BulleidNeil Lab. 🙏🏾 @wellcometrust for funding. pnas.org/doi/10.1073/pn…

Congrats team!

Plant cells undergo incomplete division and remain connected. This image illustrates two daughter cells linked by strands of endoplasmic reticulum spanning plasmodesmata—tiny bridges for intercellular communication. New findings in Science reveal that the endoplasmic reticulum holds these bridges open during cell division; without it, plasmodesmata close, addressing a long-standing question about how to combine cell division and communication. bit.ly/3C5Urfe

IRE1-dependent GOLIM4 expression controls protein secretion to modulate glioblastoma cell adhesion and migration biorxiv.org/cgi/content/sh… #biorxiv_cancer

Image 5 of 5: AstrocytER The endoplasmic reticulum (ER), a network of membranes through which proteins and other molecules move, is stained within astrocytes, the star shaped supporting brain cells. 7/7

Image 4 of 5: Amyloid Precursor Protein (APP) - an intracellular journey APP produces the toxic amyloid beta protein that forms amyloid plaques in Alzheimer's disease. Researchers found that APP's location in the cell is important for how much amyloid is produced. 6/7

Image 3 of 5: Super Nova Astrocytes and Microglia eating up amyloid plaques to fight against the build up and damage caused by misfolded amyloid protein. 5/7

Image 2 of 5: Microglia Pioneers Microglia usually help maintain brain health, but scientists believe they may contribute to the development of Alzheimer's. Here, human microglia (green) grown on a thin slice of mouse brain interact with mouse neurons (red). 4/7

Image 1 of 5: The First Responders Microglia (red and cyan) respond to amyloid plaque (yellow), one of the hallmarks of Alzheimer’s. Microglia are specialised cells that can take on different roles depending on where and how they are needed. 3/7

🔔@CecileCrapart talking at #EMBOer24 about her PhD work on how ER structure dictates its function as a Ca2+ delivering device covered in pnas.org/doi/10.1073/pn… and buff.ly/45SSNs3

I hated writing—until I learned there’s a science to it | Science | AAAS science.org/content/articl…

Ribosomes hibernate on mitochondria during cellular stress nature.com/articles/s4146…

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

We are delighted to once again be named in the world’s top 100 universities in the @timeshighered World University Rankings! More: gla.ac/47Wh8hL #THEUniRankings @THEworldunirank

Final call for Scientific Outreach Grant applications! With different funding levels available, don't miss out on this chance to take your molecular biosciences activities to a new and broader audience. Deadline 9 October! ow.ly/xiTy50TBpNr

Check this out, nanopores used to look at how a chaperone works, can potentially explain how HSP70/BiP can disaggregate proteins

📰 The updated version of our paper on ER fluidics is out in @eLife doi.org/10.7554/eLife.…

MBoC Call for Papers: Special Issue on Protein Quality Control Submit an article by October 31 to be considered by lead editors: @LizMillerCU, @MRC_LMB and @Guillou76, @NTUsg Learn more and submit:molbiolcell.org/protein-qualit…

ER–plasma membrane contact sites deliver ER lipids and proteins for rapid cell surface expansion, say Madison Smith, Lincoln Gay, and Markus Babst @UofUBiology: hubs.la/Q02QBKc80 #Membrane #lipid #Trafficking #Biochemistry #ER_literature

Pre-Ai, hand drawn schematics by Ari Helenius published many years ago. Up there, Ari tells us how enveloped viruses enter our cells. Down below, Ari discovers how our cells check the quality of the proteome. Seminal discoveries. Happy 80th birthday Ari.

Paper Alert! Our new work shows collagen IV variants act by collagen IV deficiency, hypertrophic remodeling and endothelium-dependent hyperpolarization in small vessel disease, a major cause of #stroke & #dementia @eBioMedicine @TheLancet @UofGSCMH thelancet.com/journals/ebiom… a 🧵