Oncogene Cancer Research

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Oncogene Cancer Research

Oncogene Cancer Research

@OncogeneCancer

🔬 Research. Empowerment. Advocacy. Patients & families improving #LCSM outcomes via education, support & cutting-edge research

London, England Katılım Mayıs 2023
1K Takip Edilen983 Takipçiler
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Young Lung Cancer Initiative
Young Lung Cancer Initiative@YoungLungCancer·
Explaining a cancer diagnosis to your children is one of the hardest things. Jessie, diagnosed with stage 4 EGFR lung cancer, shares how she explained it to her three kids. Episode with Jessie on our YouTube channel. Thank you to @JNJNews
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ALK Positive
ALK Positive@ALKPositiveinc·
Upcoming Webinar: Living Well with ALK+ Lung Cancer Join The Patient Story on Tuesday, May 19 for an important conversation featuring Dr. Ross Camidge and ALK Positive Board member Nancee Pronsati. Register now: tinyurl.com/8pnek2mz #ALKPositive #LungCancer #ALK #NSCLC
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Sanjay Popat
Sanjay Popat@DrSanjayPopat·
Have to say #ASCO26 is going to be an amazing update into all things RET for lung and other cancers. Do make sure you checkout these sessions /posters to be fully up to speed. You won’t regRET it… @ASCO @VivekSubbiah
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Good Morning America
After the former YouTube CEO, Susan Wojcicki, died of lung cancer at 56, her husband and sisters are continuing her mission to improve how the disease is detected and treated. @ReeveWill has the story.
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Tejas Patil
Tejas Patil@TejasPatilMD·
⭐️Everything in this post is directly relevant to #lungcancer as well. #SATEEN answers the value of using sequential ADCs with a topoisomerase payload. ⚠️The answer.. There minimal to no value in sequencing ADCs with the same payload. @lcsmchat @OncoAlert @OncogeneCancer @Lung_Cancers @LungCancerEu @LungCancerRx @MedwatchKate
Mali Barbi, MD MSc | Breast & Gyn Oncologist@DrBarbiOnc

Two prospective phase II trials at #ESMOBC26 just settled something the field has been debating retrospectively. #SATEEN (LBA4): #saci+ #trastuzumab after prior T-DXd in HER2+ MBC. ORR 3.7%. One response in 27 patients. Median PFS 2.3 months. Stopped for futility. #HER3_DXd: ORR 39% in ADC-naive HR+/HER2- disease. Prior TOPO1 ADC exposure wiped that out across every subtype. Different antibody targets. Same collapse. Because resistance here is payload-driven, not antigen-driven. SN-38 and DXd are different molecules but the same mechanism. Abelman et al. (Clin Cancer Res 2025) showed acquired TOP1 mutations in 12.9% of patients at ADC progression median duration on the second TOPO1 ADC: 52 days versus 455 on the first. >>Post-ADC trial design has to start from the payload up, not the target down. #ESMOBC26 #BCsm

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Mara Antonoff, MD, FACS
Mara Antonoff, MD, FACS@maraantonoff·
Crucial reality check from @lungoncdoc: Association ≠ causation‼️ Headlines linking healthy diet/pesticides to young onset lung cancer wildly overstate limited observations without proper controls, confounder adjustment, or any assessment of causality. instagram.com/reel/DYATLHSvr…
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Tejas Patil
Tejas Patil@TejasPatilMD·
🎉EXCITED to have participated in and share our work on modelling TKI resistance in #RET #NSCLC using novel murine models. ⭐️This work was led by my brilliant colleagues Drs. Trista Hinz, Lynn Heasley & Rafe Nemenoff, @CUCancerCenter! 👇🏽SEE BELOW for details 🧵(1/9)
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ALK Positive
ALK Positive@ALKPositiveinc·
As #HopeSummit closes, we’re reflecting on a weekend full of connection & hope 🤍 From Dr @DRCamidge’s keynote to the ALK breakout with Dr. David Gerber, it was powerful to come together—patients, care partners, advocates, clinicians. We leave energised to keep sharing hope 💙
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Young Lung Cancer Initiative
Young Lung Cancer Initiative@YoungLungCancer·
YLCI Booth at @LUNGevity HOPE Summit… Thank you to Leah for holding down the fort! Come find us and say hi if you’re there 👋🤍
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Yvonne Diaz
Yvonne Diaz@Yvonne_Diaz_·
Jeff’s story shows what’s possible when clinicians, researchers & companies work together to find a path forward for an individual patient. Let’s hope zidesamtinib can become an option when neladalkib isn’t tolerated due to liver tox while we push for solutions for all.
ALK Positive@ALKPositiveinc

After discontinuing the NVL-655 trial due to liver toxicity, ALK-positive patient and ALK Positive board member, Jeff Sturm, accessed the investigational drug zidesamtinib through a single-patient IND. Read his experience here: alkpositive.org/blog/patient-p… #LearnAboutALKPositive

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