Kyuwon Kim MD PhD

"Meet the Specialist" At #IDEN 2025 with Prof Shinji Tanaka 😃

OBESITY AND IBD by @EdwardLoftus2 Obesity is a chronic inflammatory statue Adipose tissue is not biologically inert (TNFa, IL-6, IL-8, leptin, adiponectin) Postulated role in the pathogenesis of IBD Potential risk factor for adverse outcomes Trends in BMI among IBD patients at diagnosis in Olmsted County, Doubling of obesity rates in 20 years in CD and UC (Johnson AM JCC 2021 and J Clin Gastro 2024) Obese patients more likely to have a colonic phenotype; no associations in UC No consistent relationship between BMI and disease complications in CD But in UC there was associated increased risk of needed steroids and hospitalisation, but no impact on surgery California study showed no associated between BMI on hospitalisation or surgery or serious infection (Gu P Am J Gastro 2022) How does obesity impact IBD therapy? Not all meds are weight-based Obese patients less likely to receive optimal weight-appropriate therapy IFX 4mg/kg vs 7.9mg/kg AZA 1.1mg/kg vs 1.7mg/kg Higher IFX levels may be required for patients with higher visceral adipose tissue (Yarur A et al Am J Gastro 2023 Nov:118) Higher VAT ass with reduced rates of clinical and endoscopic remission (Yarur Gastro 2023) VAT may be more informative measure than BMI Bariatric surgery is acceptably safe in obese IBD patients (Bazerbachi F Obes Surg 2018) 790 patients among >300k who had bariatric surgery De novo IBD following bariatric surgery – case study of 42 patients (Braga Net MB et al JCC) and Kochhar GS AP&T 2020 – (lower rates of IBD afterwards) Impact of bariatric surgery on long-term course of existing IBD Endoscopic bariatric therapies may be effective in obese IBD patients Anti-obesity meds maybe effective in obese IBD patients Pham JT am j gastro 2024 No increased risk of AE’s in obese IBD patients GLP-1 R agonists No difference in efficacy Safety appears similar Can they reduce the inflammatory burden in IBD? Indirect effects: weight loss, glucose metabolism Direct effects: reduction in pro-inflammatory cytokines (decr IL-6 and TNFa; blockade of NFkB signalling; incr Treg activity Murine models: GLP-1RA decreased colonic inflamation in DSS colitis; ? through modulation of gut microbiota (incr lactobacillus reuteri; decr enteropathogenic staphlycoccus) 5 observational studies published (see figure) 3/5 show decreases risk of adverse IBD outcomes, flare, surgery 2/5 no difference in IBD outcomes Lily are planning RCTs of Munjaro plus Mirikizumab in UC and in CD - watch this space! #DDW2025

Back in San Diego for #DDW2025, six years since 2019. Things have changed — what I do, what I think. But the night here is still just as beautiful✨️. Listening to the masters’ lectures, I’m reminded to keep searching for what truly drives me in this academic journey❣️

U.S. FDA approves TREMFYA® (guselkumab), the first and only IL-23 inhibitor offering both subcutaneous and intravenous induction options, for adult patients with moderately to severely active Crohn’s disease #Crohns #guselkumab jnj.com/media-center/p…

No.4 in our most impactful articles of 2024 (Altmetrics) This recent REVIEW on antibiotic-perturbed #microbiota and the role of #probiotics nature.com/articles/s4157…

Check out this review article on targeting the interleukin 23 pathway in #IBD, with authors from @IcahnMountSinai ➡️ ow.ly/BqNF50UujIe

NEW STUDY: HOW DOES MILD IBD PROGRESS OVER TIME? Read our new study in Clinical Gastroenterology and Hepatology, focusing on the often-overlooked subgroup of patients with mild IBD ➡️ cghjournal.org/article/S1542-…

Vedolizumab to prevent postoperative recurrence of Crohn's disease (REPREVIO): a multicentre, double-blind, randomised, placebo-controlled trial - The Lancet Gastroenterology & Hepatology thelancet.com/journals/langa…

It was nice to see you in person! Thank you for the insightful lecture as well.😃 @ShintaroAkiyam2

Amazing GENIUS part 2 workshop! It was an absolutely fantastic day😃👍 Great thanks to @DrYoonAn @DrSagami for the lectures, and @BDYE_IBD @Sung_Wook_Hwang and prof Choi for organizing this workshop. Anticipating intestinal US to be well-established in our center as well😁

@Sung_Wook_Hwang I'm gonna get to meet you next month, Prof @Sung_Wook_Hwang, the leader of IUS in ROK! 👍

Just arrived in Brisbane My kids love Bluey!

Lemann Index #LI for assessing #bowel #damage in #CD: a real world study by Eric Prado @P_DeepakIBDMD @ryanungaro @JeanFredericCo1 academic.oup.com/ecco-jcc/advan…

Here is a recap of the #IBUS Module 1 in Tokyo. Thank you again to all faculty members and participants! #IUS #Ultrasound #Workshop @DrSagami @TakuKobayashiM1 @DrYoonAn @Kayalvn @edmundwumd @DrMikeDolinger @MariangelaAllo3

@edmundwumd You're welcome, and I'm glad you could correct it. Let me know when you visit Seoul next time😃 Also, if an IBUS module opens in Korea in the near future, it would be great to invite you as a tutor. See you!

@oselo017 @BowelUltrasound @DrSagami @DrYoonAn @edmundwu @DrMikeDolinger @MariangelaAllo3 @TakuKobayashiM1 @TorstenKucharz1 It is nice to meet you in the IBUS workshop, Kyuwon! Thank you for the account clarification :)

We are off to a great start! Here is a recap of Day 1 of the IBUS Module 1 Workshop in Tokyo. We are looking forward to two more exciting days. @DrSagami @DrYoonAn @edmundwu @DrMikeDolinger @MariangelaAllo3 @TakuKobayashiM1 @TorstenKucharz1 #IBUS #Workshop #Ultrasound #IUS

#IBUS workshop module 1 in Japan 🇯🇵. Fantastic work done by @TakuKobayashiM1 and @DrSagami in organising such a wonderful workshop. International faculty and the attendee both enjoying their time. @BowelUltrasound

@DrYoonAn @DrSagami @edmundwu @MariangelaAllo3 @TakuKobayashiM1 @BowelUltrasound @JeongkukSeoMD @Sung_Wook_Hwang Me tooo😃 Thanks again for your detailed and instructive lectures today!

@oselo017 @DrSagami @edmundwu @MariangelaAllo3 @TakuKobayashiM1 @BowelUltrasound @JeongkukSeoMD @Sung_Wook_Hwang It was so good to meet you!!

My first journey to IUS as a participant of IBUS module 1 in Tokyo😀 Thanks a lot @DrYoonAn @DrSagami @edmundwu @MariangelaAllo3 @TakuKobayashiM1 @BowelUltrasound for preparing such impressive moments. With @JeongkukSeoMD @Sung_Wook_Hwang #MinkyuKim #GwangwooKim #SihyunKim

Exercise encouragement #shorts for #IBD patients! 10,000 steps per day!! 💪💪🏻💪🏾 @EunjaGwon @AsanIbd

Dr Rubin presents the phase 3 QUASAR maintenance results on guselkumab in moderate to severe ulcerative colitis—delta is 26-31% for primary endpoint @IBDMD #DDW2024