Peter Jones

@mxwbio Exciting! I’m curious how aging was measured. Do I understand correctly that it’s aging (in a negative sense) and not maturation (often desired in organoids)?

🚀 In space, time moves differently for the brain. 🧠 A single month in orbit can accelerate aging in brain organoids by nearly a decade. All eyes are now on the organoids that have just returned to Earth from the record-breaking International Space Station Cortical Organoid Research (ISSCOR) mission aboard the @SpaceX Endurance flight after 6 months in space. Led by Dr. Alysson Muotri and Dr. Aline Martins, this groundbreaking experiment sent nearly 200 cortical brain organoids into orbit to accelerate aging processes. The organoids were derived from neurotypical individuals of different ages as well as patients with Alzheimer’s disease. 🎯 The goal: Create advanced models of age-related neurodegeneration and unlock new possibilities for therapeutic screening. Now back on Earth, these organoids are undergoing in-depth analysis, including functional electrophysiology recordings on MaxWell Biosystems MaxTwo Multi-Well HD-MEA System, to uncover how space-accelerated aging impacts brain development, function, and neurodegenerative processes. A big shoutout to Dr. Natalia Chermont and Luisa Coelho for their key contribution in this amazing project. This experiment marks a major milestone for space biology and neuroscience. We are incredibly excited to see what these organoids will reveal. Brain research is entering a new orbit. 🌍✨ #Neuroscience #Organoids #AlzheimersResearch #SpaceResearch #Electrophysiology @SSCDiscovery

@BugejaCarl Very fast! But any info on how slowly it can spin? Can the rotational position be read out?

I just uploaded a new PCB Motor Build video on my YouTube channel, summarizing the last 3 years of research and prototyping. The results are incredible & it managed to pass 1.6 billion spin cycles! Check it out 👉 youtu.be/CVszJMlvZcA?si…

Great to see all the fantastic progress in just the first year!

@Cmdr_Hadfield @Haskoli_Islands The book Children of Time has an interesting version of such a future. 🐜 🕷️

There used to be no ants in Iceland, now there are 5 different species there. Mars will be the same. Article: tinyurl.com/xwwnfhkz @Haskoli_Islands

@liamjdrew That’s for sure - I meant more a live-stream of the implantation. But maybe if they get it to be as routine as they hope, they’ll show off the surgery and first recordings

@p2jones I dunno, I’ve seen some incredibly moving demos of BCIs in action… we’ll see

Here’s me chatting about this week’s Neuralink announcement - m.youtube.com/watch?v=fEpyXj…

@ThomElston Fantastic, I still need to see a neuropixels probe in action some day. You know of any Tübingen groups using them?

@p2jones Peter! Yes, I think our chats back then really helped me appreciate how cool these (and other) probes are. Definitely getting heaps of neurons - hundreds per probe per day. I hope our paths can cross again before too long :)

15 more probes and equipment to set up another recording rig. We're fully making the switch!

@BehrendsLab @KawanoLab__tuat Ha, not really! I could complain that I missed the final day because of overlap with our PhD student seminar at NMI, but that's not a real complaint.

@p2jones @KawanoLab__tuat what? Are you suggesting there was another one? 😂

先週ドイツで行われたBFNMにて、D3竹内さん、D2滝口くん、D2山地さん、M2藤田さんが発表を行いました！ D2滝口くんがポスター賞を受賞しました！おめでとうございます🙌

@BehrendsLab @KawanoLab__tuat It’s a good indication when a typo was one of the only weaknesses!

@KawanoLab__tuat ...and we can't even spell Nanop(o)re!🤦 Anyway, thank you @KawanoLab_tuat for coming and bringing so many brilliant young people!

Finally: thank you all for attending our first Black Forest #Nanopore Meeting😊 in Freiburg! Thanks a lot to all the highly interesting talks☺️,the particularly inspiring poster session👏 and for the great exchange👍!Let`s stay in contact 👋#Clusters4Future #bfnm23 @BehrendsLab

So many fantastic new results on solid-state nanopores, including from @Norcada @imec @northernanopore. Returned home full of new ideas and even more motivation! Thanks to all organizers including @hahnschickard @BehrendsLab @nanodiagbw #bfnm23 #nanopore (2/2)

Looking back on the Black Forest Nanopore Meeting⚛️: We @NMI_DE had great discussions about our work in @nanodiagbw. I learned lots about proteomics, mass-spec vs. #nanopores, how molecules move through pores and the challenges of engineering new bio or solid-state pores. (1/2)

@Sergiu_P_Pasca @chrost_hugo Thanks! Found it in Fig. S1 nature.com/articles/s4158… Reading the rest of the details will take a bit longer than looking at a nice image.

@p2jones @chrost_hugo It’s related to our recent screen in forebrain assembloids: nature.com/articles/s4158…

Interneurons (green) migrate across the assembloid, in a way similar to how they migrate into the cortex during brain development. Credits: @Sergiu_P_Pasca #MedTwitter

@fluxotronlabs How many mating cycles can it take? Can you share who produced this?

This socket can mount a bare die onto a board by pushing down on it from above. In between the die and the board there is a thin material that becomes conductive only in the Z direction when force is applied

@awaicekhan Is there any argument against posting a preprint along with submission (everyone can read it immediately) and then not worrying whether the final version is open access?

Yeah … Our paper got accepted! We conducted years of research, spent countless hours to analyze, interpret, & write the manuscript. Editors & reviewers voluntarily spent their time ensuring its quality. Now, we need to pay $4,430 so that you can read it. Isn't that ridiculous?

"Our students, faculty & staff are tired... We need to consciously rethink what we are doing & why we are doing it... As university communities, we need to change our belief that more equals better. Many times, more just equals more." insidehighered.com/opinion/views/…

@kenshirriff How big is this wafer?

Here's a silicon wafer for Intel's iAPX 432 processor (1981), a failed "micro-mainframe". Each rectangle on the wafer is one processor chip. But what are those five unusual rectangles? Those are test circuits... 🧵

@laughinghan @a_m_mastroianni A prison is as secure as its tallest wall? A chain-link fence would fit better to the weak-link metaphor, but doesn't roll off the tongue as nicely.

@p2jones @a_m_mastroianni Weak link vs tall wall? A series of walls is as hard to scale as the tallest wall (Note the reverse is true in parallel rather than series. Parallel links bind as strongly as the strongest link; conjoined walls protect as well as the lowest wall)

There are two kinds of problems: strong-link problems and weak-link problems. Weak-link: quality depends on how good the *worst* things are Strong-link: quality depends on how good the *best* things are