Paramita Sarkar

My background in medicinal chemistry has been at the core of my understanding and perspective while working across various fields of research (all ultimately aimed at fighting #AMR). Here are some of my thoughts on "looking back and moving forward in medicinal chemistry".

2025 was a BIG year for GARDP 🎉 We delivered our first FDA-approved product, proving that a not-for-profit partnership model can drive antibiotic development with access from the start. Looking ahead to 2026, we’re excited to expand our impact and continue tackling AMR. 🚀 Happy New Year and a successful start to 2026! 🎆 #AMR #AntimicrobialResistance #GlobalHealth #NewYear #GARDP

"Antimicrobial resistance disproportionately impacts patients with cancer, because many have weakened immune systems that make them completely reliant on effective antibiotics." @Forbes examines how #AMR is undermining #cancer care and harming patients forbes.com/sites/juergene…

The Molecule Behind Exercise’s Anti-Aging Effects *Today's letter (link in 6/6) reviews a new paper in @CellCellPress published 2 days ago. And includes a shoutout to someone special. 💪1/6) Nothing matches the health benefits of exercise. It’s the closest thing we have to a universal prescription for healthy aging. But have you ever wondered how movement actually slows aging? Movement isn’t magic. Exercise initiates a complex cascade of biochemical events that lead to adaptations designed to improve whole-body health. By identifying what those adaptations are, we can tap into the systems nature has evolved to optimize our health. That’s the question the researchers behind today’s study explored. They weren’t trying to replace exercise — but they were curious if they could “bottle up” part of its benefits. Method: In this study, 13 relatively sedentary men were instructed to exercise by running 5 kilometers — first every other day, then every day — for 25 days. The researchers measured a broad suite of metabolites in their bodies before and after the exercise regimen... #exercise #healthspan #longevity #staycurious

It was a pleasure to host Cèsar de la Fuentez @delafuentelab in Würzburg! A great day spent learning more about his excellent work on applying AI to antibiotic discovery and exchanging thoughts on other things. Looking forward to our paths crossing again.

The fungal crisis is here and desperately needs addressing: A quick assessment of the armamentarium of antifungal agents shows just how underprepared countries are...fungal infections receive less than 1.5% of all infectious disease research funding statnews.com/2023/02/09/fun… #AMR

A part of my PhD research has been published in @ACSCentSci. The article describes the streamlined development of a dual-functional antibiotic adjuvant which shows potency against complicated Gram-negative bacterial infections and exhibits promising immunomodulatory properties.

These are the 20 most-studied bacteria — the majority have been ignored go.nature.com/3C6pFTR

Bactericidal antibiotics release DNA that activates TLR9, while static antibiotics do not. Can profoundly impact treatment outcome. Should clinicians consider this when choosing antibiotics? Amazing work by Julia Gross and collaboration with Iain Fraser! nature.com/articles/s4146…

Over the moon to be named among the #50ScientistsThatInspire across diverse fields by @CellCellPress! A heartfelt thank you to my former and current lab members, mentors, collaborators, and friends—you are my daily inspiration! cell.com/news-do/50-ins…

Have a look at this CFP Editorial, on the upcoming Special Issue at ACS ID- "Microbiota, Infections, and Host Immunity"! Inviting submissions on microbiome research in infectious diseases! @ACSPublications @ACSBioMed @Yuanqiao1002 shorturl.at/3kxw0

@SudipJNC @honey @prof @HaldarlabJNCASR Congratulations 👏

Thank you @SRISTI INNOVATIONS, @SRISTI.ORG, @Honey Bee Network @Prof. Anil Gupta for the honor. Thanks to all the present and past members of @HaldarlabJNCASR for the help and support.

Exciting news! I started the junior research group 'Complexes in Phage-infected Cells' at Helmholtz Centre for Infection research @Helmholtz_HZI looking forward to explore new jumbo phage biology. We’re hiring! Join us for a PhD position.

Proton motive force and antibiotic tolerance in bacteria "maintaining proton motive force is necessary for the survival of antibiotic persisters" …icro-journals.onlinelibrary.wiley.com/doi/10.1111/17…

Today's Lancet climate and health report presents 56 indicators of health and climate change across FIVE domains. (Download the report for free from the Lancet website). Here is a thread of some of the key findings. #Lancetclimate24 (1)

Very happy to share the recently published collection on "Biologically Active Natural Products" together with Journal of Natural Products, ACS Pharmacology & Translational Science, and ACS Infectious Diseases! Link: pubs.acs.org/page/vi/biolog… @ACSPublications @ACSBioMed @sonjakrane

I am excited to finally share this preprint from @JoergLab. We've developed a reporter assay to enable high throughput discovery of carriers for ASOs into bacteria. This was a challenging and exciting journey for me, from MedChem/ChemBio into Mol/SynBio.

Excellent analysis of why new antibiotics don’t make it to patients. Plazomicin (Achaogen) financial post-mortem ⁦@JohnRex_NewAbx⁩ amr.solutions/2024/10/14/pla…

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Physics to John J. Hopfield and Geoffrey E. Hinton “for foundational discoveries and inventions that enable machine learning with artificial neural networks.”

Antimicrobial resistance could kill 40M by 2050. It is one of the greatest challenges of our time. Check out our latest article in @LancetMicrobe @TheLancet to learn about its impact and how AI and other innovations can help fight it. 🦠🤖 thelancet.com/journals/lanmi…

New review article in The Lancet Microbe Antimicrobial resistance: a concise update thelancet.com/journals/lanmi… #AMR #OpenAccess #OA