Peter Potapov 🧙‍♂️

Eli Lilly has done it. They've gone and made what seems to be a powerful, permanent gene therapy for LDL cholesterol. That means they'll be able to effectively prevent most heart disease with a single infusion!

I’m a spitz mom for a 5 days

Q: How are job postings for software engineers rising rapidly despite AI agents automating coding? A: Because there’s far more code to manage than ever before. We’re already seeing a 14x YoY increase in GitHub commits, and it’s accelerating. AI has dramatically lowered the cost of writing code, so it’s now being used across far more businesses, applications, and use cases. We’re at the beginning of a massive productivity boom driven by the proliferation of bespoke software throughout the entire economy. Coding has been AI’s breakout use case this year. The fact that it’s increased demand for software engineers — rather than decreased it — should call into question the entire “AI will cause mass job loss” narrative.

Geoffrey Moore says startups die in the chasm because pragmatist buyers demand a "whole product." These folks won't tolerate gaps. They need references. They need the complete solution. The chasm is lethal because because the buyers won't buy without perfection. But Moore's model assumes there's an EXISTING solution the buyer is comparing you to. The whole framework assumes the buyer has a status quo they're comfortable with. When the *bar is zero*, when the alternative is literally "we die" or "we do this entirely by hand with 2,000 people" (Block's compliance team) or "we just don't have this capability at all"? The chasm doesn't exist for those. Buyers start acting like visionaries instead of skeptics, because they have to buy. The alternative doesn't exist. They'll tolerate a 60% solution, missing features, no references, because 60% of something beats 100% of nothing. The companies I get most excited about aren't disrupting incumbents. They're filling voids. 9 Mothers in the YC Spring 2026 batch is a counter-drone defense co for whom bar is zero, there is no viable close quarters defense otherwise! There's no chasm to cross for that. The practical implication for founders: if you're in a market where the bar is zero, stop worrying about whole product, stop worrying about crossing the chasm, stop worrying about pragmatist references. Ship the 60% solution. They're begging for it. If you're NOT in a bar-is-zero market (if there's an incumbent, a status quo, a "good enough") then Moore applies in full and you need the whole playbook (beachhead, bowling alley, whole product, the works). The question every founder should ask: is my customer's current alternative literally nothing? If yes, you're in a different game than the textbooks describe. Ship it in whatever form you have. You'll know. And it's a great place to be.

The biggest bullshit move by DHS in its history. So everyone on a O1 or H1B visa would have to stop working legally in the US, go back to their country and wait for years of backlog? This includes top scientists in our universities, founders of billion dollar companies (at least 3 just in our portfolio would be affected by the way). And if we look at individual countries it becomes even more bs. Indians would have to wait decades. Russians don’t have anywhere to go (there is no US embassy in Russia, hello?). This is the worst imaginable way to disrupt important work for the country and pretend you’re fighting some loophole.

Elon Musk reveals the single idea that explains why he keeps working despite being worth $800 billion "When I was a teenager, I had an existential crisis trying to figure out what's the meaning of life. It doesn't seem to be any meaning" "For me at least, the religious texts that I read did not seem convincing. Then I started reading the philosophers. You have to be careful of reading German philosophers as a teenager. It's definitely not going to help with your depression" "Reading Schopenhauer and Nietzsche, as a kid you're like, whoa" "Then I read Hitchhiker's Guide to the Galaxy. What Douglas Adams was saying is that we don't really know what the right questions are to ask. The real problem is trying to formulate the question. To really have the right question, you need a much bigger computer than Earth" "The universe is the answer. What is the question? Or what are the questions?" "The more we can expand the scope and scale of consciousness, the better we can understand what questions to ask about the answer that is the universe" "The more we can expand consciousness, become a multi-planet species, ultimately a multi-stellar species, we have a chance of figuring out what the hell's going on" "This is why I think we should have more humans and more digital, both biological and digital consciousness"

Wow, if that's a real screen recording, wanna try Tripo ASAP