Petar Kanev

Hey there, PARP1 and DNA repair enthusiasts! Check out our very (!) detailed and recently published “Protocol for quantifying PARP inhibitor-induced changes in PARP1 dynamics and activity through live-cell imaging” @STARProtocols star-protocols.cell.com/protocols/4485 👇A short thread!

Have you ever wanted to track individual #chromosomes during #mitosis? To do live cell #karyotyping and map the inter- and intra-chromosomal contacts dynamics? Our recent work made that possible. Check out our @NatureCellBio paper: nature.com/articles/s4155…

@holland_tom styles make fights

“The Romans, who always defeated the Greeks, have found it very difficult to defeat the Persians, whom the Greeks always defeated.” Julius Africanus ponders a riddle of military history...

nature.com/articles/s4146… We are glad to see further evidence confirming our finding that loop extrusion is dispensible for the spread of gH2AX (doi: 10.1016/j.isci.2024.110826). #loopextrusion #cohesin #dnarepair #DDR #DSB

Happy New Year from Social DNAing to you all! Let us roll with 2025!

Contributing to efforts toward elucidating the response to replication stress, we provide a precise timescale of fork stalling and restart in live cells, at 30-s resolution (airyscan teaser below). biorxiv.org/content/10.110… #replicationstress #DNArepair #ATR #replication #DNA #RPA

If you are curious whether loop extrusion is required for γH2AX spread and MDC1 recruitment, you can have a look at the most recently published work from our lab out now in iScience #dnarepair #ATM #MDC1 #γH2AX #DDR #loopextrusion #cohesin cell.com/iscience/fullt…

“Grandiloquent, idle, useless, inactive & timid.” Obituary of the Dauphin, Louis of Guyenne, following his death of dysentery in December 1415

We are happy to share our latest paper “A unified mechanism for PARP inhibitor-induced PARP1 chromatin retention at DNA damage sites in living cells”, out today in @CellReports. #PARP1 #PARPinhibitor #GenomicStability Hopefully not a boring thread ↓ cell.com/cell-reports/f…

A unified mechanism for PARP inhibitor-induced PARP1 chromatin retention at DNA damage sites in living cells dlvr.it/T71MKK

Interested in protein dynamics and #DNArepair? Why not work with the experts at Sofia BioImaging Node? The Node has 2 new instruments for Fluorescence-lifetime imaging microscopy (#FLIM) - and #funding for Bulgarian researchers. Learn more ⤵️ eurobioimaging.eu/news/opportuni…