Laboratory of Genomic Stability

Here we can see how #centrosome motion contributes directly to chromosome redistribution

We use #AI based #denoising, #segmentation and #tracking to follow dynamics of intra- and inter- chromosomal contacts during mitosis with 8-second resolution

Have you ever wanted to track individual #chromosomes during #mitosis? To do live cell #karyotyping and map the inter- and intra-chromosomal contacts dynamics? Our recent work made that possible. Check out our @NatureCellBio paper: nature.com/articles/s4155…

nature.com/articles/s4146… We are glad to see further evidence confirming our finding that loop extrusion is dispensible for the spread of gH2AX (doi: 10.1016/j.isci.2024.110826). #loopextrusion #cohesin #dnarepair #DDR #DSB

Are you looking forward to 2025 as much as we are? 👀 We just updated our 2025 EMBL Annual Poster to include even more courses and conferences for you to join, so go and have a look! ➡️ s.embl.org/poster-x #EMBLEvents #molecularbiology #lifesciencetraining

”David Baker, Demis Hassabis and John Jumper, your ground-breaking work in computational protein design and protein structure prediction has revolutionised these fields. It has opened up completely new possibilities to design proteins that have never been seen before, and we now have access to predicted structures of all 200 million known proteins. These are truly great achievements.” Watch the very moment the chemistry laureates received their Nobel Prize diplomas and medals during the 2024 Nobel Prize award ceremony. #NobelPrize

Congratulations to Bruce Stillman of @CSHL on winning the ASBMB's Stadtman Award. Join us in Hemisfair Ballroom C2-3 for his award lecture, happening now! #DiscoverBMB

How many PCNA/RPA molecules are loaded and removed per min during fork stalling and restart? How do DDR inhibitors influence these dynamics? We estimate these rates in our pre-print, out on bioRxiv: doi.org/10.1101/2024.1… #microscopy #DNArepair #genomestability #DNA #replication

Contributing to efforts toward elucidating the response to replication stress, we provide a precise timescale of fork stalling and restart in live cells, at 30-s resolution (airyscan teaser below). biorxiv.org/content/10.110… #replicationstress #DNArepair #ATR #replication #DNA #RPA

If you are curious whether loop extrusion is required for γH2AX spread and MDC1 recruitment, you can have a look at the most recently published work from our lab out now in iScience #dnarepair #ATM #MDC1 #γH2AX #DDR #loopextrusion #cohesin cell.com/iscience/fullt…

Happy to share that our collaborative work on SARS-CoV-2 VLP dynamics is now available as a pre-print. #SARSCoV2 #COVID19 #virology #tracking #imaging Kinetic landscape of single virus-like particles highlights the efficacy of SARS-Cov-2 internalization. biorxiv.org/content/10.110…

We are happy to share our latest paper “A unified mechanism for PARP inhibitor-induced PARP1 chromatin retention at DNA damage sites in living cells”, out today in @CellReports. #PARP1 #PARPinhibitor #GenomicStability Hopefully not a boring thread ↓ cell.com/cell-reports/f…

🧬Team led by @Alberti_Lab cracks a fundamental #DNADamage question. Broken DNA is held together by an underwater protein superglue💧! Now published in @CellCellPress, with new insights for #cancer therapies. Read more ➡️ bit.ly/3SxnU6n #CMCBnews

We are delighted to share that this tour de force is now out, shedding further light on the mechanisms that keep broken ends close. #parp1 #genomestability #dnadamageresponse #parpinhibitor

How does #PlasmaMembrane repair work? This is what @PNepachalovich of @FedorovaLab aims to understand using super fast #spinningdisc confocal microscopy 🔬in collaboration with experts at @LGS_IMB, our Sofia Node🇧🇬. Learn about this exciting project!⤵️ eurobioimaging.eu/news/observing…

Interested in protein dynamics and #DNArepair? Why not work with the experts at Sofia BioImaging Node? The Node has 2 new instruments for Fluorescence-lifetime imaging microscopy (#FLIM) - and #funding for Bulgarian researchers. Learn more ⤵️ eurobioimaging.eu/news/opportuni…

Our collaboration paper on the resolution of R-loops by INO80 has been published yesterday - rdcu.be/b60Zg

Very fast CRISPR on demand science.sciencemag.org/content/368/64…