The PLUSS Trial

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The PLUSS Trial

The PLUSS Trial

@PlussTrial

Intratracheal budesonide + surfactant to ⬆️ survival free of BPD in extremely preterm infants | @nhmrc @MCRI_for_kids @chiesigroup @thrasherfund

🇦🇺🇳🇿🇨🇦🇸🇬 Katılım Eylül 2017
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Clinical Epi & Biostatistics Unit (CEBU)
Clinical Epi & Biostatistics Unit (CEBU)@CEBU_Melbourne·
Huge congratulations to the @PlussTrial team and our amazing statisticians, Kate Francis and Susan Donath, for their double win at the @ACTA_org Trial of the Year Awards! 🎉The ACTA STInG Excellence in Statistics Award recognizes their commitment to rigorous trial methodologies.
Brett J. Manley 🤷🏼‍♂️@drbretty

Wow what an International Clinical Trials Day for the @PlussTrial!! The @PlussTrial was awarded the @ACTA_org Clinical Trial of the Year, and the STInG Excellence in Statistics Award, presented to Kate Francis from @MCRI_for_kids #neotwitter @IMPACT_PSANZ @UniMelbMDHS @nhmrc

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The PLUSS Trial
The PLUSS Trial@PlussTrial·
Today the @PlussTrial was awarded the @ACTA_org Clinical Trial of the Year!!! As always the first people to thank are the incredible families and babies of who took part in the trial 🙏🏻 And of course thanks and congratulations to the entire @PlussTrial team! #neoTwitter
The PLUSS Trial tweet mediaThe PLUSS Trial tweet mediaThe PLUSS Trial tweet media
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The PLUSS Trial retweetledi
Brian King
Brian King@BrianKingNeo·
The most recent @AAPneonatal Journal Club webinar is available - youtu.be/beh82Mgor7Q Dr. Aung (Neonatal-Perinatal Fellow, St. Christopher's Hospital) gave an excellent overview of the PLUSS trial. Thank you to @drbretty and Dr. Watterberg for joining! #neotwitter @NeoTECaN
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The PLUSS Trial retweetledi
JAMA
JAMA@JAMA_current·
In extremely preterm infants receiving surfactant, early intratracheal budesonide may have little to no effect on survival free of bronchopulmonary dysplasia. @PlussTrial ja.ma/4frrMQI
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The PLUSS Trial
The PLUSS Trial@PlussTrial·
Thanks go first and foremost to the amazing babies and their families that participated in the @plusstrial! 🙏🏻 And to the sponsor @MCRI_for_kids and funders incl. @nhmrc and @ChiesiGroup And of course to the wonderful group of investigators who made it all happen! (13/END)
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The PLUSS Trial
The PLUSS Trial@PlussTrial·
So, disappointingly 😔, the @PlussTrial found that intratracheal budesonide mixed with surfactant had little or no effect on survival free of BPD in EPTIs… Longer term outcomes are important and we are currently assessing participants at 2 years of age (PLUSS2) (12/X)
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The PLUSS Trial
The PLUSS Trial@PlussTrial·
We powered the @PlussTrial to find a 10% increase in the primary outcome of survival free of BPD at 36w PMA: from 50% to 60% We needed 1038 infants and we aimed for 1060 The trial recruited in 21 tertiary NICUs in 4 countries (mainly 🇦🇺 & 🇳🇿, 1 centre in 🇸🇬 and 1 in 🇨🇦) (6/X)
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@ACTA_org @AAPneonatal @drbretty @NeoTECaN @JAMA_current @ChildrensPhila @NeonatalResearc @TracyALieu