StoP-AD Center

1/5 We are about to release the PREVENT-AD Stage 2 open dataset that will include PET, MEG, … and 5 yrs of additional cognitive FU. 🥳 @alexa_pichetb @prevent_ad

Study found that Aβ and tau PET positivity in cognitively unimpaired individuals was associated with near-term progression to mild cognitive impairment and, among those who do not show such categorical change, longitudinal cognitive decline. ja.ma/3OLjqF4

1/3 New lab paper suggesting, in 4 independent cohorts of cognitively unimpaired individuals, that the presence of both amyloid and tau-PET positivity is associated with near-term #AlzheimersDisease clinical progression. Strong support for the NIA-AA preclinical research criteria

Our most important clinical paper so far. In the @prevent_ad, 60% of our cognitively unimpaired participants with amyoid and tau PET binding developed MCI in ~2 years, a number that increased to 80% in those with hippocampal atrophy. The findings are replicated in 3 cohorts.

New article from @sylv_villeneuve 's team, @prevent_ad in @NatureComms Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease doi.org/10.1038/s41467… #alzheimer #brain #amyloidosis #aging #MachineLearning

Looking for motivated Data Analyst for multimodal analyses in neurodegeneration (e.g. Alzheimer's). Mathematical, statistical, machine-learning skills and interest in neurobiology are requirements. For details, please check douglas.research.mcgill.ca/research-assis…

Six of our researchers obtain a CIHR Project Grants Congratulations @markpaulbrandon @MCGeoffroy R. Mizrahi, J. Poirier, @pedrorosaneto @sylv_villeneuve douglas.research.mcgill.ca/six-our-resear…

PhD opportunity‼️ I am looking for a #PhD student to investigate the influence of #lifestyle on #cognition & #neuroimaging markers of #ageing and #Alzheimer Access to the offer and application details below 👇

Find out what the PREVENT-AD is, what data is made openly available and where to get it @NeuroLibre! Thank you to all who contributed to acquire and make this data available. We look forward to the community using the data! #openscience sciencedirect.com/science/articl…

Open Science Datasets from PREVENT-AD, a Longitudinal Cohort of Pre-symptomatic Alzheimer’s Disease sciencedirect.com/science/articl…

McGill to me: “I am pleased to inform you that the Board of Governors of McGill University has approved the grant of tenure and the promotion to the rank of Associate Professor to you...” I GOT MY TENURE !!

Paper in @elife: How whole-brain gene transcripts drive interactions among tau, amyloid, CBF, structural changes and pathology spreading in Alzheimer’s and Aging? Results from multi-scale universal formulation, by brilliant PhD-candidate @technoryta, elifesciences.org/articles/62589

Another beautiful paper by @alexa_pichetb in collaboration with @maxdescoteaux using novel pipelines from @scil_udes. doi.org/10.7554/eLife.… @eLife @mcgillu @DouglasResearch @prevent_ad #Alzheimers #STEM #amyloid #tau

Congrats to @SivaniyaSubram for acceptance of her paper “Sex differences in brain aging among adults with family history of Alzheimer’s Disease and APOE4 genetic risk” w @j_snytte in collaboration w @arossotto @EinsteinLabUofT in NIMG:Clinical! Stay tuned for #openaccess link!

@Raamana_ @sylv_villeneuve Hey Pradeep! We have started on some of this already :) Have you looked at our preprint? biorxiv.org/content/10.110…

@sylv_villeneuve @prevent_ad Looking fwd to read it. I'd be curious to learn more about the upcoming extensions focusing more on prediction- and ML-oriented analyses.

New paper from the lab suggesting that vascular risk factors are associated with a decline in resting-state functional connectivity over time in the @prevent_ad cohort. Vascular risk factors should really be more targeted for healthy aging and AD prevention.

Proud to present our latest findings on the association between vascular risk factors and longitudinal resting-state functional connectivity in @prevent_ad! All my thanks goes to such a great team @sylv_villeneuve, @alexa_pichetb, @_JakeVogel_, @pf_meyer sciencedirect.com/science/articl…

You can access more of the PREVENT-AD data openly! A lot of work has gone into this, particularly from @sylv_villeneuve’s team. It was a lot work but we are delighted to share this with you! #openscience