Matic Proj

Finally out. A study on a library of heteroaromatic nitriles that enable a selection of appropriately reactive derivative for bioconjugation reactions. Great work by @projmatic @UL_FFA pubs.acs.org/doi/10.1021/ac…

🎉 Happy New Year!!! 🎉 We wish you all a safe, healthy and happy year in 2023! @RamiloGomes @projmatic @BorsariChiara @Laiajc @CaroMedChem @PiiaBartos @MMMChemistry @SeanMcK27 & the rest of YSN Board

@ACSBioMed @UL_FFA Link to the paper: pubs.acs.org/doi/10.1021/ac…

When thiazole derivatives are identified as screening hits, their reactivity should be carefully addressed and correlated with specific on-target engagement. By @projmatic et al. from @UL_FFA.

Not all molecules that mislead are PAINS or aggregators: An analysis of ways thiazoles can trick assays involving cysteine-bearing proteins @ACSMedChemLett practicalfragments.blogspot.com/2022/11/the-ag…

@PracticalFrag @ACSMedChemLett Fragment-sized thiazole hits should indeed be carefully evaluated to confirm specific on-target engagement. Thanks for highlighting our research!

[ASAP] Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe? dx.doi.org/10.1021/acsmed… #medchem #feedly

The YSN team finally reunited over the #EFMCISMC22 missing @BorsariChiara and @marta_piquero

The First Paper published by DELopen users from University of Ljubljana, Slovenia #DELFinder DNA-encoded library screening on two validated enzymes of the peptidoglycan biosynthetic pathway delopen.org/scripts/1800 #DELopen doi.org/10.1016/j.bmcl…

ProBiS-Dock: A Hybrid Multitemplate Homology Flexible Docking Algorithm Enabled by Protein Binding Site Comparison #cheminformatics pubs.acs.org/doi/10.1021/ac… @koncj @SkBlaz @projmatic #current_issue #JCIM #Bioinformatics

Our latest TPD research now online as a preprint: Expanding the PROTAC Toolbox: Targeted Degradation of the Deubiquitinase USP7 in Cancer | ChemRxiv. lmy.de/VQrs8 #chemtwitter @KroenkeLab @IzidorSosic

Zotero 6: Your research workflow, transformed zotero.org/blog/zotero-6

Check our latest work on developing redox activity and thiol reactivity assays for the detection of nuisance compounds #drugdiscovery

@EuroMedChem Thank you! 🥳

🏆 Winner announced! 🏆 The winner of the Advent Calendar contest is @projmatic, with his excellent 96-well Christmas tree. Congratulation Matic, and a warm thanks to all our contestants. #EFMCAdventCalendar #medchem #chembio

🎉 Happy New Year!!! 🎉 You’re all so important to us. Stay safe, stay happy and we look forward meeting you all very soon! 🙏 Best wishes for this New Year 🙏 @Martapiquero1 @RamiloGomes @projmatic @BorsariChiara @Laiajc @CaroMedChem @PiiaBartos & the rest of YSN Board

🎄Advent Calendar - Day 4 🎄 96-well Christmas tree from @projmatic 🎉 Do you have a festive pic for our advent calendar? Send it to us and get a chance to win a prize! 🎁 #EFMCAdventCalendar #medchem #chembio

The virtual poster hall at the #FiMC2021 conference is live! You can visit my poster: Discovery of selective fragment-sized immunoproteasome inhibitors. Many thanks to the authors from Budapest and Ljubljana for all their contributions #MedChem #FBDD