Jakub Schimmelpfennig

🧵 Endogenous DMT: What Do We Really Know? Two recent papers shed new light on endogenous DMT, its biosynthesis, regulation, and function: 📄 Exploring DMT: Endogenous Role and Therapeutic Potential – by @psychedmt 📄 N,N-Dimethyltryptamine (DMT) in Rodent Brain: Concentrations, Distribution, and Recent Pharmacological Data – by Steven Barker This thread summarizes key findings. These studies challenge the idea that DMT exists in only trace amounts and has no biological role. Let’s dive in. ⬇️🧵

New discovery! Different anesthetics all seem to push the brain into unconsciousness in the same way: Activity is destabilized and dominated by slow waves. This could block signals. cell.com/cell-reports/f… #neuroscience @MIT_Picower @mitbrainandcog @mcgovernmit @ScienceMIT

"It's not magic, it's psychology."

Emerging evidence shows higher cognition relies on rhythmic electric fields—acting like "radio waves"—to enable large-scale organization, executive control, and energy-efficient analog computing. Catch Professor Earl K Miller’s Presidential Special Lecture at Neuroscience 2025 neuronline.sfn.org/scientific-res… @MillerLabMIT #Neuroscience #Bioelectricity #CognitiveScience #AnalogComputing #SfN25

I read this recently: pubmed.ncbi.nlm.nih.gov/41444454/ It says 2A blocker studies often "over-dose the blocker" and thus lose specificity to 2A. Could this apply here? pubmed.ncbi.nlm.nih.gov/33850049/

Buzzy times: theguardian.com/science/2026/f…

Ecodelia and the lost art of lichenthropy - On becoming fungus on acid and on being publicly ridiculed by grass on Salvia My latest Substack exploring the psychedelic experiences leading folk to connect & communicate with, or transform into other species davidluke543044.substack.com/p/ecodelia-and…

Interested in cortical wave dynamics? Check out our review on the physics, physiology, and psychology of cortical waves led by J Cruddas with @jchrispang Out now in @NeuroCellPress sciencedirect.com/science/articl…

This is significant: nature.com/articles/s4159…

There's some wisdom here, perhaps. Absolute outcomes like response and remission may well be better post-approval. On this front, it's almost as if Compass stacked the deck against efficacy so as to "play the game" well. That's a clear contrast vs the Lycos story. It's a good point to end on.

Same point here. I think this is the main takeaway. To say it simply: on face value, Compass are still on track for approval, having played the game well.

@MillerLabMIT @Jeanvaljean689 Hey @MillerLabMIT, what’s your take on Selen Atasoy’s harmonic decomposition method?

@Jeanvaljean689 Yes. Even down to the molecular level: Cytoelectric Coupling: Electric fields sculpt neural activity and “tune” the brain’s infrastructure. Progress in Neurobiology, doi.org/10.1016/j.pneu…

wait, it's really vibes all the way down?

Time to de-anthropomorphize the mind. New research proposes a unified framework viewing cognition as a biological spectrum—from single cells to complex mammals. Intelligence isn't just neural; it's embodied life-regulation and information processing found across all living systems. 🧠🦠 frontiersin.org/journals/syste… #DiverseIntelligence #BasalCognition #Biology #CognitiveScience #PhilosophyOfMind #BiologicalIntelligence #AI

Traveling waves. Your brain has them. There must be a reason. Cortical traveling waves in time and space: Physics, physiology, and psychology cell.com/neuron/abstrac… #neuroscience

Is your whole body conscious? “Biological systems need a cognitive, adaptive information-processing system long before you have neurons named brains.” “Every intelligence is collective intelligence.” Episode with the awesome @AnnaCiaunica is live ⬇️

LSD Reconfigures Cortical Dynamics Through Faster Brain Rhythms and Increased Fractal Dimension biorxiv.org/content/10.648…

Our work comparing the effects of a psychedelic and an advanced meditation practitioner in the brain and mind covered by @newscientist #Echobox=1770229269" target="_blank" rel="nofollow noopener">newscientist.com/article/251409…

Is true agency born from energy constraints and real-time physics? ⚡️Biological computationalism suggests that to engineer #consciousness, systems must actually "feel" the physical cost of their computation. t.co/lOCh0lWlMX #EmbodiedCognition #Agency #Robotics #BioEngineering #Neuromorphic #MindBody #Computationalism #CognitiveScience @InferenceActive

Waves of activity travel around cortex. Here's how they arise from biologically plausible constraints (spatially organized, directionally biased connectivity). doi.org/10.64898/2026.… #neuroscience

Working memory is not steady state. It is dynamic and rhythmic, like much of everything in cortex. Dynamics of working memory drift and information flow across the cortical hierarchy doi.org/10.1073/pnas.2… #neuroscience

Cool special issue celebrating Karl Friston’s legacy. A masterclass in neuroscience history. mdpi.com/1099-4300/27/9… #Neuroscience #ActiveInference #KarlFristonNews #BrainDynamics #Neuroscience @InferenceActive #ComplexityScience #BrainScience