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@TejasPatilMD @lcsmchat Very important early data

😴TP53 reactivation strategies have been tried for decades… ⭐️However, a 20% ORR for rezatapopt is HUGE! This is monotherapy response, in a heavily pretreated population. 🤔My excitement is most in combination with other drugs, will have to see how AEs settle out. @lcsmchat @OncoAlert @OncogeneCancer @OncLive @LungCancerEu @Lung_Cancers @MedwatchKate @YoungLungCancer @ALKPositiveinc @EGFRResisters @ros1cancer @KRASKickers

Live on the BBC - talking about the King and cancer. #bbc #Cancer #KingCharles

@DraMartinezLago @myESMO @GrupoTTD @eClinicalMed @Erman_Akkus @ArndtVogel Very interesting- phase 3 coming??

Peg-GCSF Primary Prophylaxis in mFOLFIRINOX for Pancreatic Cancer 🧬 Randomized phase II trial 🛡️ Peg-GCSF cut grade 3–4 neutropenia 2.6% vs 38.5% 🔥 FN only in control arm (12.8%) 📈 Trend to better survival + improved QoL 👍 No increase in bone pain 🔗 doi.org/10.1016/j.ejca…

Chemistry writes the story of life. Every cell, every second, it tells it again - powered by molecular design. At the core of this process lies the citric acid cycle, the central hub of metabolism. Here, acetyl-CoA derived from carbohydrates, fats, or proteins enters a precise series of reactions that convert fuel into energy. Each step transfers electrons, drives ATP synthesis, and sustains the continuous renewal of life at the cellular level. What may seem invisible is, in fact, the most constant motion in existence; the quiet rhythm of biochemistry that powers everything we do.

Neopolem trial design poster at #ESMO25 @myESMO

@ZO2_ dinner after the Warriors game! Pleasure to meet you.

Today in @NatMed! A distinct gut #microbiome signature identified in 3,700 colorectal cancer patients, correlates with clinical stage, severity and anatomical location. The findings hold potential for new diagnostic & prognostic tools🔬🦠 🔗 doi.org/10.1038/s41591…

@pashtoonkasi @FASinicropeMD @ALLIANCE_org @OncoAlert A lot more toxicity with chemo in adjuvant setting

#ASCO25 1st plenary practice changing presentation. @FASinicropeMD Atezolizumab immunotherapy PDL1⛔️➕chemo for patients with microsatellite instability high➖MSI-High🔥 colorectal cancers. Unanswered❓ Do you need chemo? 🆚Neoadjuvant IO is 💯 DFS 👏🏽 @ALLIANCE_org @OncoAlert

📢🟠ATOMIC #ASCO25 ➡️Adj atezolizumab + FOLFOX vs FOLFOX in stage III dMMR colon ca ✅3-y DFS: 86.4% vs 76.6% HR: 0.50, P<0.0001 @OncoAlert @ASCO #cancer #oncology #MedX #colon

just voted for Gary Lineker in the National TV Awards, presenter category. Join me and share! nationaltvawards.com/vote/thanks

@Erman_Akkus @JCO_ASCO Does this trial change our management? Gemcitabine is clearly less toxic than Folfirinox and does not need a line or a portable infusion device..

💉FOLFIRINOX vs Gemcitabine for locally advanced pancreatic cancer PRODIGE 29 (NEOPAN) @JCO_ASCO ✅ORR: 42.4% vs 15.1% ✅PFS: 9.7 vs 7.7 mo HR: 0.7 (0.5 to 1.0), P = .04 ❌OS: 15.7 vs 15.4 mo HR:1.02 (0.73 to 1.43), P = .95 ➡️Only 9 of 171 patients underwent surgery in entire study population 👉doi.org/10.1200/JCO-24… @OncoAlert @ASCO #cancer #oncology #pancreatic #MedX

Epidemiology, pathogenesis, biology and evolving management of MSI-H/dMMR cancers 💥Excellent review👇 nature.com/articles/s4157…

Queen’s team part of £5.5m research project to transform bowel cancer care independent.co.uk/news/health/no…

Met 2 delightful NBA players tonight in San Francisco- Zach Levine and Lonzo Ball- good conversation and down to earth

Now ##Encorafenib + #Ceruximab + mFOLFOX is approved in 1L for BRAFV600e based off #BREAKWATER - ORR 61% vs 40% - mDoR: 13.9mos vs 11.1mos - AEs:GI tox, rash

✳️”Low sugar diet” question comes up in daily practice frequently as it is believed that “sugar feeds cancer”❗️ ✳️It is so important to differentiate “cancer prevention” and “treatment of advanced stage cancer” and they are highly different process; with distinct molecular & biological dynamics ‼️ Some key points on this matter particularly important for patients with GI cancer and CRC👇 @manjuggm @CrcTrialsChat @oncodaily @OncoAlert

Nivolumab plus Ipilimumab in Microsatellite-Instability–High Metastatic Colorectal Cancer | New England Journal of Medicine nejm.org/doi/full/10.10…

I am off to the UAE to review oncology care. An amazing opportunity to see how things are done elsewhere- to learn and to improve care. #Oncology #UAE

@FIFAcom @FCFSeleccionCol

Counting down the days to the #U20WWC! 🤩🇨🇴 More than 100 girls took part in a football festival at @FCFSeleccionCol’s headquarters in Bogota, inspiring the next generation of Colombian stars:

The genomic landscape of 2,023 colorectal cancers nature.com/articles/s4158…