


Javi
6.2K posts

@rameerez
Built and sold @PromptHero (scaled it to 4M+ users/mo), now making https://t.co/5nkYFCnfUL, AI startups, and open-source 💎 Ruby gems (180k+ downloads)







Researchers have identified a consistent chemical difference in the brains of people with anxiety disorders: significantly lower levels of choline-containing compounds. A groundbreaking 2025 meta-analysis by UC Davis Health scientists revealed this biological marker through proton magnetic resonance spectroscopy (1H-MRS) data. The study found an average 8% reduction in total choline (tCho) in the prefrontal cortex, a key region for emotional regulation, decision-making, and cognitive control, as well as across broader cortical areas. Analyzing 25 datasets involving 370 individuals with anxiety disorders (including generalized anxiety disorder, panic disorder, and social anxiety disorder) and 342 healthy controls, the researchers documented this reduction as a transdiagnostic feature consistent across different anxiety conditions. This represents the first meta-analysis to identify a reliable chemical pattern in the brains of people with anxiety, pointing to measurable neurochemical alterations rather than purely psychological factors. Choline, an essential nutrient obtained from foods such as eggs, salmon, and soybeans, plays a vital role in brain cell membrane integrity and neurotransmitter synthesis. The authors suggest that heightened arousal and chronic stress in anxiety disorders may increase choline demand, depleting levels faster than dietary intake can replenish them and potentially impairing the brain’s ability to regulate the fight-or-flight response. While the findings open promising avenues for nutritional interventions, experts stress that dietary or supplemental approaches should complement, not replace, established treatments. [Maddock RJ, Smucny J. Transdiagnostic reduction in cortical choline-containing compounds in anxiety disorders: a 1H-magnetic resonance spectroscopy meta-analysis. Molecular Psychiatry. 2025. DOI: 10.1038/s41380-025-03206-7]


I think a big part of this is having a weekly social event of a few hours (like church) is incredibly healthy We now did 53 weekly coworking events in my house and it's a great way for people to stay social Being social in 20s is easy (or was for me), there's always something going on, and you're single so dating is social itself In your 30s it gets harder, people are more busy, you're probably in a relationship, you might hav kids, so you think you need less social cause you get it already from your family but you need friends outside of that Organizing a weekly event whatever it is and kinda putting effort to ask people to come works Some weekly coworking days we have had 30 people, others it's just 3 people, one time nobody came and it was just me! But regardless I (or @rameerez when I am not at home) organize it This one was after my birthday party last week! Anyway I can recommend everyone to organize a weekly event, mine was inspired by @csonotes original Bali coworking events, and you can do same in your town or neighborhood! It doesn't have to be coworking, can also be group workout or board game meetup or debate club, whatever, something to get people off their phones and out the door! And it's healthy!








Chrome 146 includes an early preview of WebMCP, accessible via a flag, that lets AI agents query and execute services without browsing the web app like a user. Services can be declared through an imperative navigator.modelContext API or declaratively through a form.