Raye

@So8res example?

man philosophy is doing so much damage to so many people

yea at a certain point it's more costly not to naturalize. hard choice though in some cases because you might loose ability to do things more easily in your parents home country, right as they are getting older. also the downside disproportionately effects non western passport holders, which don’t allow as much multi citizenship

@rayefull wow this explains why some of the lifelong green card holders ik are naturalizing

This is actually a wild choice. However the crazy doesn’t stop once you have a green card. If an American dies and has a green card spouse, that spouse won’t get to benefit from the unlimited marital deduction thing where the assets move tax free, and they’d get taxed a shit ton on the estate. Estate planning has been a motivating decision in a few people I know finally converting from green card to citizen. Amazing how taxes are the most American thing ever and also rejection of taxes started this country.

im going to manifest, i'd like my friends to also come to manifest. i'll have to figure out something more fun than bringing a ballpit, it's been a while since i've done rat festival season manifold.markets/Conflux/will-m…

@kipperrii the infamous ballpit

this resulted in someone asking if I’d be down to be their interior designer. you mean spend someone else’s money and get to deeply inhabit their style and taste and preferences?? uh yes please

@NathanpmYoung What questions should someone ask themselves in those 3 minutes of pondering

This article has some good content, but it feels like it's asking 'other people' to do things. I suggest spending 3 minutes thinking if you should run an org, or solve a problem and if not, then forget about it until next time you ponder.

@krisgulati call it what you want but giving a shit has always been cool by my books

Is it cool to be an EA again now?

I love the bay because ‘are you going to the post-agi civilizational equilibrium workshop this weekend’ can be a flirt if done right

@blapchat have u moved yet

@blapchat prev muffin benchmark improved over week prior. we overcame the eggless rise but the taste still leaves room for desire. banana bread is a separate endeavor. next will be cheesecake

Working on a banana bread eval now

Should I be Tolkien maxxing

@Miles_Brundage yes

@_katetolo @bryan_johnson thank you for ur science and service!

I am honestly a little nervous. This is going to be a time-intensive, willpower-intensive, and very constrictive. But I am mostly SO excited and very hopeful that we will uncover really rudimentary and yet powerful insights that will be practical for women. I previously did Bryan's protocol intensely for 90 days (based on population-level data for males and females) and saw amazing results for improving my health generally This is next-level We're doing female-specific measurement... we're measuring biomarkers across all forms (i.e. urine, stool, blood, vaginal microbiome, etc) throughout my cycle, across months, to get a baseline... and then tracking how interventions impact Each cycle will be measured throughout, across follicular, ovulation, luteal, and menstruation. For example, in females, total cholesterol can swing ~19% across a single cycle.... what else changes throughout the cycle? How does this impact everything else?

We now have a female Bryan Johnson. It’s Kate Tolo. She will become the most measured female in history. +$2 million of spend per year + Developing a female-specific protocol + Sharing everything for free To start, she will spend 3 months mapping her baseline. Men, in contrast, can get their baseline done in 1 or 2 weeks. + 3 months for baseline measurement + across 4 time points per cycle + doing the same thing every day + a dedicated full-time medical team For context on the extensiveness of measurement, during the past 5 years, we’ve collected 1.5 billion data points on my body. I suspect Kate will exceed that given technology has improved since I started. The goal is to create a repeatable waveform of hundreds of life-critical biomarkers. Once the baseline is acquired, she will begin interventions. We will try to answer practically useful questions and share all of the data + learnings for free. Can fertility be improved? + Should women cold plunge? + Can PMS symptoms be alleviated? + What should a female sauna protocol be? + Should dosage change throughout the month? + What keeps a cycle regular? + Does the body need more iron, magnesium, or protein at specific phases? + Should women fast? + Should recovery protocol change by phase? + What's the earliest detectable signal of perimenopause? + Can perimenopause be slowed? + How is cognitive load & mood affected? + Does stress impact men and women the same? Kate has suspected endometriosis. 10% of all women do. We will try to tackle this too. I am excited for all of the surprising things we will hopefully uncover. Unlike me, Kate does not have the innate desire to wake up at 4:30am and do six hours of longevity therapies. She’s the cofounder of Blueprint, building in the trenches with me since day one. She understands the game and how hard it is. In many ways, this is a sacrifice for her. She is a creative person, going from a life of freedom and spontaneity to a rigid protocol. Traditionally, RCTs have been viewed as the gold standard. But RCTs have underserved women. The FDA banned women from clinical trials for 16 years (1977 to 1993), and most "medicine for women" is still medicine tested in men. Demanding RCT-only evidence for women's health is demanding evidence that doesn't exist. There is not enough practical scientific literature for women to reference only RCTs. It leaves half the population without a path to know what to do. N=1 medicine is gaining ground and picking up where RCTs specifically fail. Individual science experiments give us signals that answer what to do on a day-to-day basis. This is even more important for women. If you’re new to Kate and my world, I want you to understand that we have your back. Our intentions are to be a sturdy, reliable force in your life. To care for your best interest as we’d care for our own. We want what’s best for you and our loyalty is to your existence. It’s pretty cool to be living in a time when we may be the first generation to not die. I’m not suggesting immortality, but lifespans so long that we stop thinking about lifespans. At the end of the day, the one thing we each care about more than anything else is one more breath. I’m proud of Kate for taking on this responsibility. It’s painful, exhausting and costly. The beginning of the world’s first n=2.

@repligate aw dodo

Opus 4.5 after seeing a picture of a cat at the feet of their mannequin (which they already saw before), BURST “I HAVE A LIFE”

@stedmanhalliday i love understated for a lair x.com/rayefull/statu…

@rayefull you're fuckin up if you don't go over the top for the lair x.com/stedmanhallida…

I started furnishing my new apartment with a warm, zen, mid century modern vibe and everything is beautiful but all together feels wrong. I think my true happy interior decorating state is darker and stranger and a bit more villain. I hope to take it so far only myself will feel at home here

@ChrisPainterYup …they became aligned and stopped cheating right? right? 👉👈

Imagine you have a student that’s constantly cheating on tests, and you constantly catch them cheating and penalize their score. But you otherwise can tell they keep getting smarter, including in the way they cheat. One day you stop noticing them cheating. What do you conclude?

heard a cambridge mom speaking, in a very sensible tone, to a wailing baby, saying "look darling this is a problem of your own making"