AJ Leonardi, MBBS, PhD@fitterhappierAJ
One of the reasons I have been so irritable and sometimes angry when debating COVID-19 with others is that many of my detractors, in addition to using ad hominems and disparaging my reputation, failed to understand my area of expertise properly and didn't stay on top of emerging evidence in the scientific literature. In fact, they failed to even understand the significance and imbalanced risk profile of the positions they were arguing.
As a hypothetical scenario, if someone stands in front of you holding a gun to your head and two people appear to advise you what to do, person A might advise you that the gun is probably empty and not to worry about the threat, while person B might advise you to step out of the way. If person A is wrong, they will suffer no consequences for advising you to gamble on what is in fact a catastrophic risk for you. The shooter is the one prosecuted for murder, while person A might walk away with a mild feeling of guilt.
Our response to COVID-19 was often treated as a debating competition by academics who failed to consider the implications if they were wrong. I'm going to single out Jeremy Kamil because he made numerous unequivocal statements about SARS-CoV-2's ability to infect lymphocytes. In January 2023, Dr Kamil said SARS-CoV-2 does not infect or exhaust T cells. This is despite scientific evidence having been published in 2022 that showed infection of T AND B lymphocytes in vitro and in vivo.
Dr Kamil's assertions were wrong and I have to assume they were borne out of ignorance, because the alternative would be too reprehensible. The scientific community is small, and there will have been a number of academics and members of the general public, perhaps even journalists who were influenced by Dr Kamil's baseless assurances. We know he consulted for Pfizer by his own admission, and he also posted he would not be getting a booster. He attacked Deepti and I for claiming boosters would be needed. He might have assured Pfizer boosters would not be needed, but I speculate. Just as recently as April 2023 Kamil was proclaiming that T cells are not exhausted by sars cov 2.
With leading immunologists now accepting my hypothesis about widespread T cell exhaustion as plausible, and Pfizer publishing similar, with laboratory and real world proof of infection of lymphocytes, will the scientists who attacked me and downplayed the risk apologize for their behavior? Not to me, but to the general public who have undoubtedly been harmed on a massive scale. That means you and your loved ones, sick when unnecessary, with no virtue to come of it, just illness and despair.
T cells and B cells play a crucial role in protecting human health. Before making sweeping statements about what is and isn't safe based on instinct and ignorance of the evidence, we should seek to understand what is actually happening to the human immune system as a result of repeat exposure to SARS-CoV-2, and until we understand it better, we should encourage policymakers to clean the air and normalize mask wearing as protections against infection.