Reaslab

We're enrolling participants in an NIH-funded study to understand blood-brain barrier disruption with anti-amyloid immunotherapy for Alzheimer's disease. Learn about the study in this video and please contact us if interested in participating! #alzheimers youtube.com/watch?v=8kCrQx…

New paper in Imaging Neuroscience by Emilie T. Reas, Jennifer S. Graves, et al: Long COVID-related blood-brain barrier breakdown and microstructure in older adults are modified by sex and Alzheimer’s disease genetic risk doi.org/10.1162/IMAG.a…

@serasolders She also examined if method of operationalizing leakage matters, comparing continuous permeability vs "abnormal leakage index (ALI)" of above-threshold values. Results were comparable between methods, supporting robustness of findings, though ALI cutoff influences effect size

New work from postdoc @serasolders shows patterns of blood-brain barrier leakage in cognitively normal APOE4 carriers. BBB breakdown correlated with microstructural brain injury only in groups with high Alzheimer's disease risk (APOE4+, amyloid+, women) sciencedirect.com/science/articl…

In case you missed this spring's NIH workshop on "Blood-Brain Barrier Transport in Aging and Alzheimer’s Disease," the meeting summary is now available. Check it out! #bloodbrainbarrier #Alzheimers #aging nia.nih.gov/research/dn/wo…

Characteristics of blood–brain barrier heterogeneity between brain regions revealed by profiling vascular and perivascular cells | Nature Neuroscience nature.com/articles/s4159…

@MeredithBraskie Thanks so much, Meredith!

Congrats to the authors on this interesting paper from @reas_lab!

Our paper hot off the press in @alzdemjournals shows APOE4 carriers have blood-brain barrier breakdown even *before* amyloid accumulation or cognitive impairment, which correlates with microstructural damage. alz-journals.onlinelibrary.wiley.com/doi/10.1002/al… #Alzheimers #APOE #bloodbrainbarrier #dementia

🚨 paper alert!! Thrilled to finally share part of my grad school work out today in @NeuroCellPress! Will be of particular interest to those studying endothelial-microglial interaction. Spoiler alert - PLX5622 has off-target effects on ECs! A 🧵 below.. cell.com/neuron/fulltex…

Monumental work from @AkassoglouLab showing that fibrin promotes inflammation and neuropathology following COVID-19, with protection from fibrin immunotherapy. Exciting implications for treatment of long COVID! nature.com/articles/s4158…

📢 NEW video out of our @loft_lab! 3D rendering of small cerebral blood vessels visualized & segmented on 3D high-resolution black blood MRI with isotropic 0.5mm resolution acquired at clinical magnetic field strength of 3 Tesla 👀👀 @KECKSchool_USC

#UCSD is looking for individuals to participate in a #study investigating the effects of #COVID on the brain. Adults aged 50+ who are experiencing persistent long-COVID symptoms or have fully recovered may be eligible. Contact info and compensation detail can be found below.

Dear colleague & amazing neurologist Dr. Jose Soria is seeking participants for the Viva Mind study, testing a new #Alzhiemersdisease treatment (varoglutamstat) that may be safer & more convenient than current drugs. Find out more in his recent interview! fox5sandiego.com/video/alzheime…

Congratulations to postdoc @serasolders on receiving the NIA T32 ADRD training fellowship! 🎉 Be sure to follow this rising star to keep up with her exciting research developing Alzheimer’s disease neuroimaging biomarkers!

#APOE modifies #Alzheimers risk but how does it affect preclinical neurodegeneration? We found lower entorhinal neurite density in cognitively normal E4 carriers & surprising white matter differences in E2+. Read all the juicy details in our new pub! link.springer.com/article/10.118…

My newest project with @PaLab_UCSD exploring the role of cerebrovascular reactivity in developing mild cognitive impairment is now out in @alzdemjournals!🧠alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

A study by researchers including co-author @etreas, a #UCSDSOM assistant professor, and collaborators at @KPWAResearch determined that changes in the brain related to hearing loss may lead to an increased risk of dementia. 🧠 🗞️ Read more: buff.ly/47vrqEF

Never too early. The @NIH will no longer co-endorse the updated #Alzheimers guidelines with the @alzassociation. Does the NIA recognize that Amyloid Isn't Alzheimer's? A refreshing dose of governmental sobriety. @forbes forbes.com/sites/howardgl…

A program at @UCSanDiegoSPH aims to improve diversity in research and clinical careers that are focused on #Alzheimer’s Disease and Related Dementias and other aging-related topics bit.ly/3qUQGEk