RESAT CINAR

1/4 New Paper 🧠🐭 #Neuroscience #Dopamine #FearExtinction #eNeuro Altered Dopamine Signaling in Extinction-Deficient Mice eneuro.org/content/12/11/…

✨Exciting to see clinical efficacy of peripheral #CB1R antagonism with #monlunabant. It will expand armamentarium for #obesity with a different mechanism than incretins (#GLP1 #GIP) ⚡️Similar efficacies in all tested oral doses encourage testing lower doses to optimize safety.

🧵7️⃣ Our research exemplifies amazing team and collaborative effort (@m_konigshoff lab)! Big shout out to @abhishekbasu86 @muharif #antifibrotic #TherapeuticDiscovery #DrugDiscovery #PulmonaryFibrosis #CurePF #CureHPS #CB1R

🧵6️⃣ 📌 #Zevaquenabant treatment effectively reduces #fibrosis in human precision-cut lung slices (#hPCLS). 📌 Pulmonary delivery of zevaquenabant may offer a more targeted and safer #therapeutic modality for #fibrotic #lung #diseases

📣Our research @JCI_Insight highlights the key role of #cannabinoid receptor 1 (#CB1R) in #AlveolarMacrophages in promoting #PulmonaryFibrosis. We propose that pulmonary delivery of #zevaquanabant as an effective and safer therapeutic approach for PF insight.jci.org/articles/view/…

‼️A post-doc position available in my lab at the NIH ‼️ ⚡️Fibrosis Biology ⚡️Biomarker Discovery ⚡️Pharmacology ⚡️Therapeutic discovery ⚡️Translational research See the position details👇 training.nih.gov/jobs/pdf-09062… #postdoc #Fibrosis #pulmonaryfibrosis #RareDisease Please RT

Our research shows anandamide in blood has biomarker functions in Hermansky-Pudlak syndrome. It not only captures early stage fibrosis progression in lung but also informs on therapeutic effect for CB1R antagonism.This may help to design effective anti-fibrotic therapy @CureHPS

📣 New Hurd Lab paper in @molpsychiatry explores how cannabidiol (#CBD) can help reduce anxiety linked to specific triggers. Learn more about our findings 🧵 and read the full paper: nature.com/articles/s4138… (1/7)

Meet Lenny Pommerolle, Ph.D., @pommerollelenny, a postdoc in NIAAA’s Section on Fibrotic Disorders, is studying the biological mechanisms altered by alcohol consumption that leads to immune dysregulation in lungs.

Study by @IRPatNIH scientists in #NIAAA's intramural program sheds light on gender-specific mechanisms by which chronic alcohol exposure affects lung immunity—and finds differences between males and females. Read the article here: pubmed.ncbi.nlm.nih.gov/39024537/

@pommerollelenny will present our recent work @NIAAAnews on how chronic alcohol consumption induces sexually dimorphic and detrimental effects in lungs via inducing immunometabolic changes at European Respiratory Society Congress #ERS2024

@tony_jourdan1 @ctm_dijon @NIAAAnews @IRPatNIH @pommerollelenny Thanks @tony_jourdan1 . All credit to @pommerollelenny and @ctm_dijon team for this important paper! We are lucky to have Lenny working with us.🍀 He certainly continues to keep up with good work for impactful scientific discoveries.

Great work from a former @ctm_dijon PhD student now performing a high level postdoc at @NIAAAnews @IRPatNIH uneer my dear friend @resatcinar supervision. Keep up the great work @pommerollelenny , more to come your way!

Congrats to @pommerollelenny and @ctm_dijon team for this impactful work! This work not only endorsed CD206 expressing macrophages as a profibrotic macrophages in progressive #pulmonaryfibrosis but also elegantly provides an imaging tool to use biomarker function of CD206 imaging

The blood biomarker functions of #Anandamide may help targeted prophylactic or early therapeutic interventions in a highly predictable fibrosing #rarelungdisease #HPSPF in the future.

#CB1R antagonism reversed circulating #AEA in serum and attenuated progression of pulmonary fibrosis in the experimental model of HpsPF.

Our preprint presents #endocannabinoid #anandamide (#CB1R agonist) in blood has both early disease #biomarker and surrogate marker functions in Hermansky Pudlak syndrome pulmonary #fibrosis (#HPSPF) @HPSNetwork