rorypmulloy

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rorypmulloy

rorypmulloy

@rorypmulloy

Dabbles in the outdoors, viruses, and RNA granules. Catch me PhDing at uCalgary with @Corcoran_Lab

Calgary Katılım Mayıs 2020
384 Takip Edilen186 Takipçiler
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Corcoran Lab
Corcoran Lab@corcoran_lab·
Our newest work reveals that SARS-CoV-2 evolved to produce a truncated version of its nucleocapsid protein to antagonize antiviral responses: it sequesters dsRNA, blocks interferon activation, defeats RNaseL and disassembles stress granules and p-bodies. biorxiv.org/content/10.110…
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Lena Steckelberg
Lena Steckelberg@LenaSteckelberg·
1. Hi #RNA friends, just in time for the holidays I am excited to share the latest pre-print from my group. We solved the structure of a mysterious viral RNA that resists degradation by host nucleases. A short 🧵 & link below – please also check out the full video! #lovevirology
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WaelSSKamel
WaelSSKamel@WaelSKamel·
It is finally OUT!! After a pandemic, lab moving across the country!, 1+ under review and >120 panels later. 🧵 cell.com/molecular-cell…
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Joshua Mendell
Joshua Mendell@Mendell_lab·
I’m thrilled to share this story from @Mendell_lab and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu! We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation. science.org/doi/10.1126/sc…
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Corcoran Lab
Corcoran Lab@corcoran_lab·
Huge congratulations to the newly minted Dr. Kleer who defended her PhD thesis on Wed! An outstanding thesis and defence. It was a privilege and a pleasure to supervise such a motivated and enthusiastic scientist @marielkleer. Thank you @jkarijolich for serving as the external!
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SheqLab
SheqLab@ShechnerLab·
Beyond thrilled to present our O-MAP—now *published* @naturemethods (!!!) O-MAP is a powerful new method for biochemically "dissecting" the subcellular microenvironment around an RNA of interest, using off-the-shelf parts and standard manipulations. 🧵 nature.com/articles/s4159…
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Alfredo Castello
Alfredo Castello@Alf_Castello·
PhD position opportunity to work an interdisciplinary team at the @UofGlasgow in AI tools to uncover critical host-virus interactions... Exciting 🙌. If not for you, please share with anyone you think might be interested 👌. Thanks 👍
Craig Macdonald@craig_macdonald

📣 Interested in AI and biology? PhD position at @robertson_lab on predicting virus-host interactions using protein language models. An exciting collab w/ @david_l_robertson, @ir_glasgow (myself), @keyuan1 and @AlfredoCast Apply 👉 gla.ac.uk/colleges/mvls/…

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Cambridge RNA Club
Cambridge RNA Club@CambridgeRNA·
Welcome back RNA enthusiasts to Cambridge RNA Club! Our first session of 2024/2025 is next Thursday at @GurdonInstitute. We look forward to some talks from Emilia Arguello and Andres Ramos! Thank you to our sponsors @RNASociety and @lexogen
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Mariel Kleer
Mariel Kleer@marielkleer·
Easily my favourite discovery of my PhD was staining KSHV infected cells for the kaposin RNA, going to the microscope, turning it on, and seeing gigantic nuclear dots. KSHV uses the kaposin RNA to reorganize the cell nucleus for successful gene expression. Preprint below!
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Corcoran Lab@corcoran_lab

We are really excited to share this story! We discovered that a major function of the KSHV RNA, kaposin, is as an architectural non-coding RNA that recruits nuclear speckles proximal to viral genomic RNA. biorxiv.org/content/10.110…

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Corcoran Lab
Corcoran Lab@corcoran_lab·
We are really excited to share this story! We discovered that a major function of the KSHV RNA, kaposin, is as an architectural non-coding RNA that recruits nuclear speckles proximal to viral genomic RNA. biorxiv.org/content/10.110…
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Rik Lindeboom
Rik Lindeboom@RLindeboom·
Extremely excited to see our paper out in @Nature! How does the body respond to SARS-CoV-2, and what happens if you don't get infected after exposure? We unravel the exact timeline of the cellular responses to inoculation with SARS-CoV-2 in humans. (1/4) nature.com/articles/s4158…
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Keşfet

@corcoran_lab @rorymulloy @Mendell_lab @marielkleer @jkarijolich @SciImmunology @GeroneGon @Liam_Wilki