Rik Lindeboom

Exciting news for aspiring PhD students: the NKI PhD Program 2025 will open soon for applications! We participate with multiple top labs in this prestigious program, which offers a unique opportunity for PhD candidates to engage in cutting-edge genome biology and cancer research.

Passionate about doing innovative, curiosity-driven research and looking to start your own lab? The NKI has an opening for a Junior Group Leader position! Join us in our collaborative environment in Amsterdam, to use our state-of-the-art infrastructure to make a real impact.

Happy and proud to receive the ERC Starting grant! We will investigate how genome-wide binding kinetics and energy landscapes of oncogenic transcription factors are regulated! Interested in joining our team? Apply before the 22th of Sept. #ERCStG nki.nl/news-events/ne…

Excited to share that we received the Technology Impact Award from @CancerResearch to develop methods to study immune - cancer cell interactions for identifying proteins and antigens that modulate cancer cell killing, and targets for immunotherapy! cancerresearch.org/cri-funded-sci…

I'm #hiring a PhD student! Join the Lindeboom Lab at the @NKI_nl on an exciting project to explore oncogenic transcription factor binding kinetics and biophysics using state-of-the-art technologies! Apply now or share this exciting opportunity! nki.nl/careers-study/…

@Ella_Maru @Nature Many thanks Ella! Great question! We couldn't find such correlations, but this analysis is hard to do because HLA-DQA2 expression was present in the participants that did not develop sustained infections, and therefore had no detectable viral load or broad immune responses.

Congratulations, Rik! Did your study find a correlation between high HLA-DQA2 expression and initial viral load or immune cell activation?

Extremely excited to see our paper out in @Nature! How does the body respond to SARS-CoV-2, and what happens if you don't get infected after exposure? We unravel the exact timeline of the cellular responses to inoculation with SARS-CoV-2 in humans. (1/4) nature.com/articles/s4158…

@EricTopol @Nature @BenIsraelow @VirusesImmunity Thank you for highlighting our work! We're extremely excited to contribute to the understanding of immune responses in COVID-19.

Just published @Nature Why do some people not get Covid/abort infections? Immunology insights from a challenge study indicates rapid local interferon response or elevated HLA (DQA2) expression nature.com/articles/s4158… nature.com/articles/d4158… @BenIsraelow @VirusesImmunity @RLindeboom

This was an amazing team effort by the @Teichlab and @drmarkonikolic lab. Massive thanks to my partners in crime @WorlockKaylee and Lisa Dratva, the @ChrisChiuLab that established the model, the involved teams at @sangerinstitute, @ucl, @NKI_nl, @imperialcollege, @hVIVO_UK. (4/4)

Highlights include the unexpected timing of the interferon response, new innate responses in unexpected cells and in abortive infections, identification and application of new activated T cell populations, and lower HLA-DQA2 expression as predictor for sustained infections. (3/4)

I'm #hiring a #postdoc to join my research group at the NKI in Amsterdam. Are you interested in developing state-of-the-art genomics and proteomics technologies to study TCR : antigen interactions in cancer? Apply before the 8th of May: nki.nl/careers-study/… #AcademicTwitter

Honored to be among the recipients of the NWO Open Competition M1 grant! We will develop tools to improve our understanding of TCR-antigen interactions, using high-throughput screening & AI. Stay tuned for a postdoc vacancy to join this exciting project! nwo.nl/en/news/ninete…

Nature research paper: Decoding chromatin states by proteomic profiling of nucleosome readers go.nature.com/3P7kNRC

Stoked to see this tour-the-force from the Bartke team out in Nature! We've decoded how DNA & histone modifications regulate protein binding to the genome using quantitative interaction proteomics. A leap forward in understanding chromatin dynamics! Congrats to everyone involved!

Thrilled to share my journey as a new junior PI at @NKI_nl, featured in @NatureCancer. From overcoming the challenges of setting up a lab to building a team and plotting a scientific course.

Congratulations to Piet Borst, 2023 #LaskerAward winner! – “for an exceptional 50-year career of scientific discovery, mentorship, and leadership”. ow.ly/cuFl50PNTMJ #Lasker2023 #LaskerLaureate #mtDNA #mitochondria #trypanosomes

@IgnasiToledano @JuliaDiumenge @FranSupek @BenLehner Congrats Ignasi, very important and exciting work!

Time to share my PhD work where we quantified the translational readthrough of thousands of pathogenic stop codons and trained predictive models to predict drug-induced readthrough of any stop codon. With the priceless guidance from @FranSupek +@BenLehner! biorxiv.org/content/10.110…

@slavov_n Zbtb7a used to be Pokemon, which stands for 'POK erythroid myeloid ontogenic'. But it was later changed into Zbtb7a as the the Pokemon Company threatened the discoverers with legal action.

What are some interesting gene names? I will start: really interesting new gene: RING

The NKI opened an exciting new call and PhD program for students interested in Chromosome Biology and Gene Regulation!