Saez-Rodriguez Group

The scientific community is buzzing on Bluesky 🦋 You can now also follow us there: saezlab.bsky.social

This work was led by Robin Fallegger and Sergio A. Gomez-Ochoa, supervised by @JulioSaezRod with Matthias Kretzler and Michael T Eadon. Thanks to all involved, including Charlotte Boys, @roramirezf94, @tanevski, and many more. We thank all funders and patient participants!

A step toward molecularly grounded, precision assessment of kidney injury and the possibility of non-invasive tracking of tissue damage using blood and urine biomarkers.

What does single-cell transcriptomics reveal about individual patients with acute (AKI) and chronic (CKD) kidney 🫘 disease? Can we use it to find new biomarkers? In our new preprint, we asked this using biopsies from 150+ participants from the Kidney Precision Medicine Project.

This study was led by @l_kuechenhoff, with supervision by @JulioSaezRod and @roramirezf94 & contributions from Gahyun Kim, @JanLanzer, and Matthias Kretzler. We greatfully acknowledge funding from the German Federal Ministry of Research, Technology, and Space (@bmftr_bund)

We further combine single-cell data with spatial transcriptomics to identify spatially constrained fibrotic cell signalling events shared across organs. All results are published as an open resource to support further discovery: organfibrosis.saezlab.org

🧵 See 👇 our new preprint on shared and organ-specific gene expression programs of fibrotic diseases 🧬 📄 Paper: doi.org/10.64898/2026.… 📊 Explore the data: organfibrosis.saezlab.org

Led by @martingarridorc and Clement Potel with the help of @Miralea10, Isabelle Becher, @PabloRMier, @sophia_mullerd. Supervised by Mikhail Savitski and @JulioSaezRod. With support from AIH cluster and @embl core facilities.

Original preprint: doi.org/10.1101/2024.1… Want more details on the data, prior knowledge, methods, and ground-truth sets? Everything is in the paper and the accompanying Zenodo resource: zenodo.org/records/183908…

Interested in kinase-driven signaling interactions? Check out our (now peer-reviewed) paper together with @savitski_lab on reconstructing signaling networks from phosphoproteomics data and prior knowledge: doi.org/10.1038/s41467…