Samuel Corless (@sam_corless) - Twitter Profili

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Ben Carty@ben_carty93·16 Şub

Calling all aspiring centromere biologists! Rae Brown (Straight Lab) and I will co-chair the GRS for Centromere Biology, preceding the main GRC on 27th-28th July 2024. Please retweet and register before April 21st to be considered for a talk! grc.org/centromere-bio…

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Douglas Vernimmen@DougVer·20 Şub

Join us at our 22nd @EdinEpigenetics Meeting @EdinburghUni Network #research #epigenetics #chromatin #Edinburgh

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Samuel Corless retweetledi

Edinburgh Cancer Research@EdinCRC·13 Şub

Warm welcome to our new Principal Investigator Dr Nezha Benabdallah @NsBenab👍! Nezha leads the Chromatin Regulators in Cancer research group. Her scientific interests focus on sarcoma research and chromatin biology. Read more on our website: ed.ac.uk/cancer-centre/…

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Samuel Corless@sam_corless·24 Kas

@arnaud_kr @ERC_Research @embl congratulations Arnaud, well deserved!

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Cell Press Sustainability@CellPressSust·16 Kas

Several roadblocks must be overcome to make molecular biology more sustainable, but @GreenLabGuy @ucl argues that we must treat sustainability like we do health and safety in the lab—as a necessity.

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Cees Dekker@cees_dekker·27 Ağu

a while ago I posed this question... 1/

Cees Dekker@cees_dekker

Biophysics question: In transcription, RNApol generates positive supercoils ahead of it and negative ones behind it WHY? Why doesn’t RNApol instead simply track 1 strand of the duplex, follow its helical twist along the duplex, and thus rotate without any supercoil generation?

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Samuel Corless@sam_corless·11 Ağu

Centromere biologists take note!

Claudio Cantù@ClaudioCantu81

Improve your CUT&RUNs with The CUT&RUN Suspect List of problematic regions of the genome genomebiology.biomedcentral.com/articles/10.11… by @AnnaNordin96 w/ @GianlucaZamba @ppagella86 now @GenomeBiology ❗️IMPORTANT: the Suspect Lists content did not change from the previous release @biorxivpreprint

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Samuel Corless@sam_corless·5 Tem

@TismaMilos @LipfertLab @cees_dekker wow, that's great!

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Miloš Tišma@TismaMilos·4 Tem

@sam_corless @LipfertLab @cees_dekker If we add side flow to the supercoiled DNA, we can even directly observe the plectoneme! Check this paper out: nature.com/articles/s4159…

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LipfertLab@LipfertLab·4 Tem

Visual summary of the single-molecule experiments from our recent preprint with @TismaMilos @cees_dekker --- for negative supercoils biorxiv.org/content/10.110…

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Samuel Corless@sam_corless·2 Haz

This study is amazing! I always wondered if the role of nucleosomes was more about DNA supercoils than 'packaging', these different topologies are a nice hint in that direction. biorxiv.org/content/10.110…

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Samuel Corless@sam_corless·3 Nis

Did you know JQ1 directly targets BRD4 at centromeres? #Epigenetics is more than gene regulation! To find out more read our updated BioRxiv biorxiv.org/content/10.110…

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Samuel Corless@sam_corless·16 Mar

@pablonavarroLAB oh wow, this data is beautiful!

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EPIC_Unit@pasteur@pablonavarroLAB·16 Mar

oh, nice! congrats! It immediately remind me of the 1st experiments the 1st master student (Elena Gallego) of the lab did when we were setting up in 2013/14. Never found time to invest in this surprising images of Brd4-GFP in mitotic mouse ES cells... now it makes sense! Thx!

Samuel Corless@sam_corless

Thanks chromatin community! We’ve been digging around in your repetitive DNA (>40,000 ChIP-seq samples) and have discovered a totally unexpected role for BRD4 and JQ1 at centromeres. Very happy to share our preprint. biorxiv.org/content/10.110…

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Samuel Corless retweetledi

bioRxiv@biorxivpreprint·15 Mar

The bromodomain inhibitor JQ1 is a molecular glue targeting centromeres biorxiv.org/cgi/content/sh… #bioRxiv

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Samuel Corless@sam_corless·16 Mar

Thanks chromatin community! We’ve been digging around in your repetitive DNA (>40,000 ChIP-seq samples) and have discovered a totally unexpected role for BRD4 and JQ1 at centromeres. Very happy to share our preprint. biorxiv.org/content/10.110…

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Science Magazine@ScienceMagazine·13 Mar

New research in Science presents a synapse-by-synapse map of an insect’s brain, representing a valuable resource for future experimental and theoretical studies of neural circuits and brain function. scim.ag/1RU

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Cees Dekker@cees_dekker·28 Şub

Biophysics question: In transcription, RNApol generates positive supercoils ahead of it and negative ones behind it WHY? Why doesn’t RNApol instead simply track 1 strand of the duplex, follow its helical twist along the duplex, and thus rotate without any supercoil generation?

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Samuel Corless@sam_corless·3 Mar

@cees_dekker could this instead be an evolutionary question? If RNA polymerase originally evolved to replicate RNA, perhaps the supercoil problem resulting from dsDNA was solved by evolving mechanisms to cope with (and then exploit) this phenomenon? tinyurl.com/3emwdxuc

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