@lcdsmyth @jonykipnis @Nature congrats leo, super cool study! very interested what the implications will be for brain therapeutics
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sarah borrie
2.4K posts
sarah borrie
@sborrie
Wandering neuroscientist. 🇳🇿 living in 🇧🇪. alzheimer's, autism, rasopathies, microglia, social behavior
Louvain, Belgium Katılım Eylül 2012
984 Takip Edilen393 Takipçiler
I am excited to share our latest research on the arachnoid barrier, a crucial yet poorly understood structure that partitions the CNS and the dura, out today @Nature. We discovered that gaps in this barrier allow communication between the CNS and the dura. nature.com/articles/s4158…
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sarah borrie retweetledi
We are looking for a new PhD student to work on a very exciting project on microglia-neuron interactions. If you think that fits with you please apply!
shorturl.at/jpJT0
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This whole thread bears reading. The rhetoric that was used is frighteningly similar to what we have been hearing for the last month.
The Anti-Genocide Project@justinpodur
When Germany, fresh from the genocides in Namibia, committed atrocities in Belgium in 1914 - destroying Louvain and killing 6000 civilians in massacres.
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Hey #RareDisease people, this is very serious: Taysha drops a program after FDA asks them for a randomized placebo-controlled *for a gene therapy in a neurodegenerative rare disease*
Taysha argues that such trial is not feasible.
I would even argue that it might not be ethical.
Jared Whitlock@Jared_Whitlock
The company Taysha stopped development on a therapy after saying FDA demands are unworkable. It comes amid growing debate over the regulations for treatments aimed at ultra-rare conditions. endpts.com/taysha-stops-d…
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@CNSdrughunter @PearlF completely agree, there was a lot of debate about the problems of FDA rigidity in requirements for rare disease trials in kids at the Rasopathies symposium this summer. Options for delayed start, natural history external controls (as has been tried for NF1) are really needed
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@PearlF The design is what I find unethical. A delayed start design, I can see. A placebo-controlled trial for a gene therapy (long trial) in a degenerative disease or a childhood disease means the placebo patients will miss their perhaps only chance to get better. They are not lab mice.
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sarah borrie retweetledi
Rescuing two young seals that were entangled in a net in the West Coast National Park in South Africa.
A very tangible reminder of how important it is to ensure plastic and things like this are not in our oceans.
[📹 James Suter]
twitter.com/Levandov_2/sta…
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sarah borrie retweetledi
Looking for a lab to pursue your #PhD? We are hiring!! We aim to understand the involvement of SC brain circuitry dynamics in sensory processing and movement in neurodegenerative disorders such as Huntington Disease!
Institut de Neurociències de la UB@UBneuroscience
#VACANCY | We are offering a predoctoral contract to work in a multidisciplinary research project that combines behavioural #neuroscience with neuroengineering 🧠 📅 Deadline: July 25th 🚨 Additional information buff.ly/3Oiuj4B 📢 Apply here! buff.ly/3O640hO
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Much to learn here. Also, i think morr generally all of science would benefit from researchers "understanding who they are and how that informs the research questions asked, the research relationships formed, the location of the research and the way research is conducted."
Dan Hikuroa@DanHikuroa
Indigenous knowledge is increasingly valued, but to fully respect it we need to decolonise science – here's how. Shameless promotion of recent research and resultant Conversation piece. @taramcallister4 theconversation.com/indigenous-kno…
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sarah borrie retweetledi
🧠#Brain research & innovation must be recognised, more than ever, as a #health and #research priority in the EU.
📃EBC, in collaboration with member & like-minded organisations, has launched a #PledgeForScience.
Read more & sign the pledge 👉 bit.ly/3Ic6WG7
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sarah borrie retweetledi
Thrilled to share our work showing that early alterations in the MCH-system link aberrant neuronal activity and sleep disturbances in AD @NatureNeuro.
I co-led this project with @DeStrooperLab and @joris_dewit_lab @CBD_VIB 🧠
Nature Neuroscience@NatureNeuro
An MCH-mediated homeostatic mechanism counteracts the increased excitatory drive to CA1 neurons and altered #sleep in Alzheimer's disease model mice, but this mechanism fails in older mice New from @SaraCalafate @joris_dewit_lab @DeStrooperLab and colleagues
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sarah borrie retweetledi
Pathogenic tau activates cGAS and IFN-I responses in microglia, and ablation of Cgas in tauopathy model mice diminished the microglial IFN-I response and protected against cognitive impairment
nature.com/articles/s4159…
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sarah borrie retweetledi
Now I'm curious: confocal gurus, what's your favorite software package for *JUST* viewing zstacks in 3D? As in being able to finely position the viewing angle & having the image rendered accordingly like those below (see alt text for image info)
#Microscopy
Victoria Lopez@NOICE_ciception
@engineering_joy I do not. Is it like Fiji / image j ? I usually use that
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sarah borrie retweetledi
Are you an undergrad seeking exciting opportunities to work alongside neuroscientists in the U.S., Canada and Europe?
The Simons Foundation is providing fellowships: lnkd.in/e_Hv-Qwj 🧠
Deadline for application: 4 May!
May the forth be with you😉
@SimonsFdn #internship
Simons Foundation@SimonsFdn
If you're interested in applying for the Simons Foundation Undergraduate Research Fellowship in Neuroscience (SURFiN) but missed last week's info session, you can watch the playback here! vimeo.com/816963487 #neuroscience #internship
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@BohacekLab It's so helpful that you actually write to decline people. Maybe it's draining for you but it's really helpful for aplicants to be able to move on rather than be left hanging cos someone can't be bothered with decline emails
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I just spend an hour politely declining a load of applications to my lab. Often very thoughtful emails with research proposals, strong CVs, lots of very smart people. Saying no to all these applicants is emotionally draining. I feel really bad. How do others deal with this?
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sarah borrie retweetledi
Negative energy balance hinders prosocial helping behavior | Proceedings of the National Academy of Sciences pnas.org/doi/10.1073/pn…
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@LetiziaMarvaldi @MeitalOren @LukasNeukomm @HippenmeyerLab @WeizmannScience @unito Super!! Have a great time :)
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Excited to be at the #EMBOneuronalRemodelling23 organized by @MeitalOren @LukasNeukomm and @HippenmeyerLab @MeitalOren is an incredibly beautiful meeting in my second home #israel where l met my friend from @WeizmannScience. l love to be here with my family. ❤️@unito
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Creative inspiration for Saturday:
Watch “THE GAP by Ira Glass” on #Vimeo vimeo.com/danielsax/theg…
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