Science Immunology

A new Science #Immunology study shows that mitochondrial fission activates host defenses via the unfolded protein response and antibacterial lipid drop formation, a pathway some bacteria can evade. scim.ag/3OYtG35

A new Science #Immunology study addresses recent, conflicting findings on the role of #IL17 in #MultipleSclerosis, showing that IL-17A and IL-17 drive disease in EAE mouse model. @KuchrooLab scim.ag/3OtoiF7

#Mitochondrial fission promotes an ancient host defense pathway in mammalian macrophages and in worms, which could be exploited for future #antibacterial treatments. Learn more in Science #Immunology: scim.ag/3OYtG35

Viral vector gene delivery of immunomodulatory cytokines IL-2, IL-1RA, and IL-10 to lung cells reduces immunopathology and improves lung function after respiratory infection in mice. Learn more in Science #Immunology: scim.ag/3OrpMj2

A new Science #Immunology study in mice shows that persistent inflammatory stress and type I #interferon signaling generates splenic #neutrophils with specialized antibacterial functions, helping clear bladder infections. scim.ag/4sBSifF

Proinflammatory lytic cell death releases cytosolic TRIM21, which binds to circulating #antibodies and is internalized by #macrophages, stimulating cross-antigen presentation and inflammation in Sjögren’s disease. Learn more in Science #Immunology: scim.ag/41xeNHN

A new Science #Immunology study highlights a gene delivery platform that can induce lung-specific immunomodulatory cytokine expression without systemic side effects in mice, restricting tissue damage after #flu infections. @LabListon @GreVVel scim.ag/3OrpMj2

During sustained inflammation, the spleen can fast-track the production of #neutrophils with enhanced #antimicrobial functions to boost host defense in mice. @Carlos_Silvest @soehnleinlab Learn more in Science #Immunology: scim.ag/4ciLSgQ

In #Sjogrens disease, the autoantigen TRIM21 forms large immune complexes with circulating antibodies, which then drive proinflammatory responses in macrophages upon uptake, a new Science #Immunology study suggests. @JelenaLab scim.ag/41xeNHN

A new Science #Immunology study shows that intratumoral regulatory T cell depletion promotes CD4 T cell-induced IL-2 production, boosting #NaturalKiller cell antitumor responses in mice. scim.ag/4cfSQ4T

A new Science #Immunology study highlights a multimodal T cell receptor mapping approach that can identify spatial distribution and transcriptional states of #antitumor and bystander T cells in human head and neck tumor samples. scim.ag/4smEJk8

Depleting regulatory T cells from tumors boosts natural killer cell activation and #antitumor activity against MHC I-deficient cancers in mice, which could inform future therapeutic strategies. @david_raulet Learn more in Science #Immunology: scim.ag/4cfSQ4T

Single-cell spatial T cell receptor profiling can reveal the distribution and gene expression profile of individual T cells in human tumors, which could inform improved #immunotherapies. Learn more in Science #Immunology: scim.ag/4smEJk8

Mutations in upstream open reading frames that regulate tumor necrosis factor receptor 1 (#TNFR1) may contribute to disease symptoms in patients with #autoinflammatory conditions like TRAPS. Learn more in Science #Immunology: scim.ag/48fkSw6

A new Science #Immunology study shows that suppressive #myeloid cells that express PD-L1 are driven by #claudin-LILRB interactions with cancer cells, which can be targeted with dual blockade. scim.ag/41Lidql

A new Science #Immunology study finds that patients with rheumatoid arthritis have increased copper levels in regulatory T cells, which could guide new therapeutic strategies for #autoimmune conditions. scim.ag/47Asw46

A new Science #Immunology study identifies two upstream open reading frames that regulate tumor necrosis factor receptor 1 levels in tissues, safeguarding against excessive #inflammation. @gyrd73 scim.ag/4tjQ45n

Cancer cells that express #claudins can interact with LILRB receptors on myeloid cells to promote immunosuppression within tumors in mice and cultured human cells. Learn more in Science #Immunology: scim.ag/41Lidql

The copper transporter #Slc13a1 supports regulatory T cell metabolism and is necessary for peripheral immune tolerance in mice. Learn more in Science #Immunology: scim.ag/47Asw46

The April 2026 issue of Science #Immunology is out! This month's cover highlights how copper can "lend regulatory T cells a hand" by sustaining their metabolic fitness and peripheral immune tolerance. Learn about this research and more: scim.ag/4m7VkGR