JelenaBezbradicaLab

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JelenaBezbradicaLab

JelenaBezbradicaLab

@JelenaLab

Oxford Katılım Mart 2020
314 Takip Edilen823 Takipçiler
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JelenaBezbradicaLab
JelenaBezbradicaLab@JelenaLab·
The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.@FabiAlexFischer science.org/doi/10.1126/sc…
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Dr Eva Frickel
Dr Eva Frickel@FrickelLab·
Hot off the biorxiv press! 🔥 @SamuelLaraR finds GBP5 enhances macrophage glycolysis via glucose uptake, GTPase activity dependent and as being cis-Golgi localised. Bonus finding, GBP5 is important for full M1 macrophage functionality. biorxiv.org/content/10.648…
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Clare Bryant (clarebryant@bsky.social)
Clare Bryant ([email protected])@ClareBryant13·
Next on Inflammazoom gasdermins with Katia Cosentino and Tanita Wein Monday at 1 GMT
Clare Bryant (clarebryant@bsky.social) tweet media
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Dave Boucher
Dave Boucher@dave_boucher·
New review from our lab. Kudos to PhD student @SebGrant346534. 10 things you wish you knew about inflammatory caspases: a holistic review of their biochemistry, activation, and signalling - Journal of Biological Chemistry jbc.org/article/S0021-…
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Dr Rebecca Coll
Dr Rebecca Coll@Rebecca_Coll·
Delighted to share that our study with @bioagelabs NLRP3 inhibitors is now online @JExpMed ! Together with @Geyer_lab @benedicte_py and @Innate_immuno we characterise BAL-0028 and BAL-0598. Excited to see the new NLRP3 biology they will reveal!
Journal of Experimental Medicine@JExpMed

#NLRP3 is a target for anti-inflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @Rebecca_Coll et al. characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. hubs.la/Q03GtbGx0

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Avinash Shenoy
Avinash Shenoy@avi_cmbi·
📢 paper - a new class of RIPK1 inhibitors. Lots of with here, with structure of it bound to RIPK1, biochemistry and more! Was fun being part of this with Tate group and many others. pubs.acs.org/doi/10.1021/ac…
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Jonathan Kagan
Jonathan Kagan@jkagan1·
Discovery of a pH sensor that regulates inflammation. Zhou and Medzhitov provide a mechanistic tour-de-force in defining how BRD4 links changes in pH to inflammatory gene expression. Kudos to the authors on this exciting finding. sciencedirect.com/science/articl…
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BSI Congress & Events
BSI Congress & Events@bsicongress·
Dive into cutting-edge innate immunity & inflammation science at our event on September 11! From immune cell roles to inflammasome signalling, discover advances shaping clinical care. Abstract deadline: 15 July Early bird registration ends: 27 August 🔗 bit.ly/43q9x9r
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