JelenaBezbradicaLab

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JelenaBezbradicaLab

JelenaBezbradicaLab

@JelenaLab

Oxford Katılım Mart 2020
315 Takip Edilen826 Takipçiler
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JelenaBezbradicaLab
JelenaBezbradicaLab@JelenaLab·
How lytic cell death drives autoantigen release and fuels inflammation? With @lynndustinlab we ask this using a common autoantigen, TRIM21. The autoantigen TRIM21 assembles proinflammatory immune complexes after lytic cell death | Science Immunology science.org/eprint/VEVN4EQ…
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Clare Bryant (clarebryant@bsky.social)
Clare Bryant ([email protected])@ClareBryant13·
Calling all Inflammazoomers: after brilliant talks from Siddharth Balachandran, Marcus Taylor, Katia Cosentino and Tanita Wein (catch up on the Abcam Hub) this Thurs we have 2 more..... Rachel Lai and Jueqi Chen GMT 15:00+1
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Dr Eva Frickel
Dr Eva Frickel@FrickelLab·
Hot off the biorxiv press! 🔥 @SamuelLaraR finds GBP5 enhances macrophage glycolysis via glucose uptake, GTPase activity dependent and as being cis-Golgi localised. Bonus finding, GBP5 is important for full M1 macrophage functionality. biorxiv.org/content/10.648…
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Clare Bryant (clarebryant@bsky.social)
Clare Bryant ([email protected])@ClareBryant13·
Next on Inflammazoom gasdermins with Katia Cosentino and Tanita Wein Monday at 1 GMT
Clare Bryant (clarebryant@bsky.social) tweet media
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JelenaBezbradicaLab
JelenaBezbradicaLab@JelenaLab·
Reminder: new #InflammaZoom free Webinar is today at 2 pm BST with James Murphy @pseudokinase from WEHI and Jonathan Maelfait from VIB Ghent. Register via Abcam link below. See you soon!
Abcam@abcam

InflammaZoom is back on October 20. Tune in from 2:00 to 3:00 PM BST for a deep dive into innate immunity and inflammasome biology. Hear from James Murphy (WEHI, Melbourne, Australia) and Jonathan Maelfait (VIB-UGent, Ghent, Belgium). Register now: bit.ly/4iXGqjw #InflammaZoom #innateimmunity #inflammasomebiology

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JelenaBezbradicaLab
JelenaBezbradicaLab@JelenaLab·
Looking forward to hosting James Murphy @pseudokinase and Jonathan Maelfait @InflamResCen as #InflammaZoom speakers on Monday October 20th. Register below via Abcam link for this free Webinar.
Abcam@abcam

InflammaZoom is back on October 20. Tune in from 2:00 to 3:00 PM BST for a deep dive into innate immunity and inflammasome biology. Hear from James Murphy (WEHI, Melbourne, Australia) and Jonathan Maelfait (VIB-UGent, Ghent, Belgium). Register now: bit.ly/4iXGqjw #InflammaZoom #innateimmunity #inflammasomebiology

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JelenaBezbradicaLab
JelenaBezbradicaLab@JelenaLab·
Do not miss this! #inflammazoom is back in October 🎉 with James Murphy from WEHI and Jonathan Maelfait from VIB Ghent we are back with some really 🔥 stories!
Abcam@abcam

InflammaZoom is back on October 20. Tune in from 2:00 to 3:00 PM BST for a deep dive into innate immunity and inflammasome biology. Hear from James Murphy (WEHI, Melbourne, Australia) and Jonathan Maelfait (VIB-UGent, Ghent, Belgium). Register now: bit.ly/4iXGqjw #InflammaZoom #innateimmunity #inflammasomebiology

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Dave Boucher
Dave Boucher@dave_boucher·
New review from our lab. Kudos to PhD student @SebGrant346534. 10 things you wish you knew about inflammatory caspases: a holistic review of their biochemistry, activation, and signalling - Journal of Biological Chemistry jbc.org/article/S0021-…
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Dr Rebecca Coll
Dr Rebecca Coll@Rebecca_Coll·
Delighted to share that our study with @bioagelabs NLRP3 inhibitors is now online @JExpMed ! Together with @Geyer_lab @benedicte_py and @Innate_immuno we characterise BAL-0028 and BAL-0598. Excited to see the new NLRP3 biology they will reveal!
Journal of Experimental Medicine@JExpMed

#NLRP3 is a target for anti-inflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @Rebecca_Coll et al. characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. hubs.la/Q03GtbGx0

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Avinash Shenoy
Avinash Shenoy@avi_cmbi·
📢 paper - a new class of RIPK1 inhibitors. Lots of with here, with structure of it bound to RIPK1, biochemistry and more! Was fun being part of this with Tate group and many others. pubs.acs.org/doi/10.1021/ac…
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Jonathan Kagan
Jonathan Kagan@jkagan1·
Discovery of a pH sensor that regulates inflammation. Zhou and Medzhitov provide a mechanistic tour-de-force in defining how BRD4 links changes in pH to inflammatory gene expression. Kudos to the authors on this exciting finding. sciencedirect.com/science/articl…
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Keşfet

@Lo_Zanzi @CellCellPress @SamuelLaraR @pseudokinase @v_hornung @InflamResCen @SebGrant346534 @bioagelabs