Kuchroo Lab

📢 New dates for ReThink Neuroimmunology: May 24–26, 2027, at the Weizmann Institute of Science. Join our spectacular international speaker lineup for bold science and deep discussions. Registration is open. Space is limited: conferences.weizmann.ac.il/RTN2026/ #RTN2027 #Neuroimmunology

🎉 Celebrating 3 Years of Impact! 🎉 On June 26, The Gene Lay Institute proudly celebrated its 3rd anniversary alongside our valued members. This milestone reflects the dedication, collaboration, and shared vision of everyone who has been part of our journey. #GeneLayInstitute

What an incredible day at the @GeneLayInst 's inaugural retreat on April 27, 2026! 🎉 Watch the retreat highlights below! 🎥⬇️ #GeneLayInstitute #Immunology #Research #LifeSciences #TeamScience #ScientificCollaboration

Join us and @GeneLayInst on July 31st for the Annual Symposium! This year's speakers include Marco Colonna, Shimon Sakaguchi, @stefanispranger, and @victora_lab. Register using the QR code in the flyer! #inflammation #immunity #disease #genelayinstitute

Online now: A cell-intrinsic glucocorticoid biosynthesis and sensing circuit maintains a homeostatic Th17 cell state dlvr.it/TT1F78

Online now: Interleukin 23 promotes a pro-inflammatory Th17 cell state by stabilizing RORγt and suppressing glucocorticoid receptor activity dlvr.it/TT1JQ4

These findings could help address steroid resistance of Th17 cells frequently seen in the clinic & constrains the efficacy of this mainstay of treatment for autoimmune flares. @GeneLayInst @MGBResearchNews @HarvardMed @BroadInstitute @WeizmannScience 3/3

2⃣IL-23 switches on a pro-inflammatory Th17 state by stabilizing RoRgt & impairing GC sensing, via epigenetic & transcriptional regulation. @AnaAndersonLab @YosefLab. 2/3 cell.com/immunity/fullt…

💫Back2back papers in @ImmunityCP led by #DandanYang: multi-omics studies reveal how the gluococorticoid (GC) pathway restrains Th17 cell pathogenicity. GC steroid synthesis & sensing maintain the homeostatic state of Th17 cells. @AnaAndersonLab 1/3 🧵 cell.com/immunity/fullt…

IL-23 promotes a pro-inflammatory Th17 cell state by stabilizing RORγt and suppressing glucocorticoid receptor activity @ImmunityCP @KuchrooLab @nir_yosef1 @WeizmannScience @harvardmed cell.com/immunity/fullt…

A new Science #Immunology study addresses recent, conflicting findings on the role of #IL17 in #MultipleSclerosis, showing that IL-17A and IL-17 drive disease in EAE mouse model. @KuchrooLab scim.ag/3OtoiF7

In this study led by Allen Ho, we re-affirm the critical role of Th17 cells, & IL-17A & IL-17F in inducing autoimmune neuroinflammation. Now @SciImmunology

An adaptive source of IL-17A/F is indispensable for EAE development! And B cell-derived IL-17 induces IL-23 signaling required to convert stem-like Th17 cells to encephalitogenic Th17 cells. @GeneLayInst @MGBResearchNews @HarvardMed @BroadInstitute science.org/doi/10.1126/sc…

B cells are a critical adaptive immune cell type in the development of TH17 cell–mediated experimental autoimmune encephalomyelitis @SciImmunology science.org/doi/10.1126/sc… @KuchrooLab @BrighamWomens

In this review, Adam, Suhail, Kuchroo, and Vignali highlight the challenges and novel approaches to developing agonistic inhibitory receptor (IR)-targeted therapies to treat #autoimmunity and inflammatory disorders. hubs.la/Q0493L5y0 #CancerFocus #LymphocyteBiology

Tim-3 restrains ILC2 function and attenuates airway hyperreactivity via NLK pathway @NatureComms @KECKSchool_USC nature.com/articles/s4146…

Review @JExpMed @Vignali_Lab @aamirbkbz @KuchrooLab Inhibitory receptor agonists: Emerging strategies in immune modulation rupress.org/jem/article-ab…

If you haven’t registered yet, now's the time! Some of the best minds in neuroimmunology, neuroscience, immunology + AI — in one room. RTN2026 | Oct 26–28, 2026 | Weizmann Institute conferences.weizmann.ac.il/RTN2026/ @jonykipnis @QuintanaLabHMS @stevens1lab @RejaneRua @WeizmannScience

By reprogramming the tumor microenvironment with an engineered virus, @QuintanaLabHMS boost anti-tumor immunity in a glioblastoma model @NatureCancer. @MGBResearchNews @broadinstitute @harvardmed massgeneralbrigham.org/en/about/newsr…

🔔 New episode alert! Dr. Ana Anderson (@AnaAndersonlab) from @HarvardMed talks about her work on #ImmuneRegulation in cancer. ▶️ bit.ly/3KzeIOO