Science Translational Medicine

Head trauma from sports can disrupt the blood-brain barrier for years in retired athletes, a highly toxic mutant protein could offer a more effective target in Huntington's disease, and more this week in #ScienceTranslationalMedicine. scim.ag/4lAsui7

How does the uterine immune system recover after transplant? A team studies uterine transplant and #HSCT recipients and shows that all immune cell lineages reconstitute despite a drop in #NFAT signaling. @nkbjorkstrom @BenediktStrunz @karolinskainst scim.ag/46TohA9

This week, a team shows that lowering the highly toxic Htt1a transcript with siRNA delays #Huntingtin aggregation and corrects transcriptional dysregulation more effectively than targeting full-length, mutant HTT. @UCLHD #HuntingtonsDisease scim.ag/4uZoOer

Traumatic head injuries from collision and combat sports disrupt the #BloodBrainBarrier and trigger inflammation for years after retirement, shows an MRI and transcriptomic analysis of retired athletes. @mattcampbelltcd @gastaut @Fro_Greene @tcdgenmicro scim.ag/4bx1iwh

Researchers present one of the largest analyses of dual-positive #CTCs in patients, tracing how these cells correlate with outcomes in advanced #BreastCancer and how they seed metastasis in mice. @CtcLaboratory @ReduzziCarol @WeillCornell scim.ag/4sbdKsL

Amino acid supplementation enhances the uptake of lipid nanoparticles carrying #mRNA therapies in vitro and in mice, suggesting this simple approach could overcome delivery efficacy roadblocks in mRNA #GeneTherapy. @biohub @ShanaOKelley @KelleyLabs scim.ag/46UbBch

A team presents vaccines for H5 clade #influenza based on a stabilized H5 hemagglutinin stem, which improves the breadth and depth of antibody responses and protects against #H5N1 challenge in immunized mice. @KingLabIPD @anniedosey @UWBiochemistry scim.ag/4reeKei

New research reveals that uterine-resident #NaturalKillerCells decline in the endometrium of recipients of uterus transplant due to NFAT inhibition after tacrolimus, and links these disruptions to pregnancy complications such as preeclampsia. @UABHeersink scim.ag/4rriIAo

Thrilled to share our new study in Science Translational Medicine: a simple amino acid “cocktail” dramatically boosts LNP delivery efficacy in a liver inflammation model. 🧪📈 Built in the @biohub ecosystem and directly advancing our grand challenge to decode inflammation. 🔥

How does the uterine immune system recover after transplant? A team studies uterine transplant and #HSCT recipients and shows that all immune cell lineages reconstitute despite a drop in #NFAT signaling. @nkbjorkstrom @BenediktStrunz @karolinskainst scim.ag/46TohA9

Studies of uterus transplant recipients reveal how immune cells shape pregnancy outcomes, an amino acid cocktail enhances nanoparticle delivery of therapeutic mRNAs in mice, and more this week in #ScienceTranslationalMedicine. scim.ag/3NgmFcX

A noninvasive test can detect liver #cirrhosis and other non-cancerous disorders in multiple cohorts by searching for cell-free DNA markers in the #fragmentome, laying the road for a flexible, multidisease #LiquidBiopsy. @av_annapragada @KimmelCancerCtr scim.ag/40b6eBK

An isoform-switching therapy for #RettSyndrome uses alternative splicing to bias the production of the e1 isoform of MECP2, leading to partial correction of disease phenotypes in patient-derived neurons and boosting MECP2 production in mice. @bcmgenetics scim.ag/4aPtCuI

Leveraging systems #immunology, researchers characterize the distinct immunological profiles produced by #RSV and #SARSCoV2 infections in infants, providing data that explain clinical divergences and could inform future therapeutics. @jacksonlab scim.ag/4kS7ras

A team presents new vaccines for H5 clade #influenza based on a stabilized H5 hemagglutinin stem, which improves the breadth and depth of antibody responses and protects against #H5N1 challenge in immunized mice. @KingLabIPD @anniedosey @UWBiochemistry scim.ag/4reeKei

We've used a blood test—cell free DNA—for detecting cancer or prenatal fetal abnormalities. It turns out it can be used to detect liver diseases and all-cause mortality from other conditions @ScienceTM science.org/doi/10.1126/sc…

A noninvasive test can detect liver #cirrhosis and other non-cancerous disorders in multiple cohorts by searching for cell-free DNA markers in the #fragmentome, laying the road for a flexible, multidisease #LiquidBiopsy. @av_annapragada @KimmelCancerCtr scim.ag/40b6eBK

A noninvasive "fragmentome" test expands liquid biopsy to liver cirrhosis and other conditions, stabilized flu immunogens could improve vaccine efficacy for H5 influenza, and more this week in #ScienceTranslationalMedicine. scim.ag/4r3Jxdx

Leveraging systems #immunology, researchers characterize the distinct immunological profiles produced by #RSV and #SARSCoV2 infections in infants, providing data that explain clinical divergences and could inform future therapeutics. @jacksonlab scim.ag/4kS7ras

Researchers in this issue uncover a new epigenetic vulnerability in #AML, showing that inhibiting KDM4 histone demethylases can indirectly reactivate the tumor suppressor gene ZBTB7A and suppress AML in patient-derived models. @jacksonlab scim.ag/4aAUU80