Dr. Dinesh Khanna

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Dr. Dinesh Khanna

Dr. Dinesh Khanna

@sclerodermaUM

👉University of Michigan Scleroderma Program leading the way through excellence in clinical care, teaching, & research #scleroderma tweets≠advice Follow≠endorse

Ann Arbor, MI Katılım Temmuz 2017
89 Takip Edilen3.4K Takipçiler
Dr. Dinesh Khanna
Dr. Dinesh Khanna@sclerodermaUM·
Exciting data on CAR-T from @Worldsclerofnd meeting in Athens in #scleroderma. Complete B cell depletion in tissue, response in RNA pol 3 Ab, and ++large clinical response. Clinical trials starting comparing CAR-T to standard of care therapies with Novartis and BMS.
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Dr. Dinesh Khanna
Dr. Dinesh Khanna@sclerodermaUM·
SLS 3 is published. acrjournals.onlinelibrary.wiley.com/doi/10.1002/ac… 1. Upfront MMF+PFD vs. MMF+PLA 2. Underpowered due to Covid 3. No difference in primary end- FVC% 4. ⬆️AE and discont with MMF+PFD What else did we learn? A. Trends favor MMF+PFD in PROs and in HRCT QILD B. Need well powered trials
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Healio Rheumatology
Healio Rheumatology@HealioRheum·
📢 There were “clinical improvements in lung function and skin thickness in patients with severe refractory #SSc, with 96% remaining off SSc-directed therapies during the follow up,” said Dr. Dinesh Khanna @sclerodermaUM. healio.com/news/rheumatol…
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Dr. Dinesh Khanna@sclerodermaUM·
Proud moment. Neha Khanna, 2nd year undergraduate at UM presenting first author poster at #ACR25. Thanks to her mentor ⁦⁦@elizatsou⁩ and ⁦@UMIntMed
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Dr. Dinesh Khanna@sclerodermaUM·
#ACR2025. Exciting data on CAR-T in SSc. Oct 26: Efficacy and Safety of BMS-986353, a CD19-Directed Chimeric Antigen Receptor T Cell Therapy: Phase 1 Trial in SSc Oct 27: RESET-SSc: Clinical Trial Evaluating Rese-cel Autologous 4-1BB CD19-CAR T Cell Therapy in Phase 1 in SSc
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Dr. Dinesh Khanna
Dr. Dinesh Khanna@sclerodermaUM·
Interested in a position at U-M scleroderma program? Expertise in analyzing omics data. We are leading center in clinical trials and one of the largest scleroderma program. careers.umich.edu/job_detail/264…
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Dr. John Cush
Dr. John Cush@RheumNow·
DID YOU KNOW? >30% of Systemic Sclerosis pts present without Raynauds!. Data from 2 large US cohorts, of SSc dx with puffy fingers/hands or other symptoms. Such patients presented with more severe skin and musculoskeletal disease. buff.ly/t6mFdB9
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MyRheumatology
MyRheumatology@rheumatologymy·
Bringing rheumatology closer to haematology. CAR-T therapy is showing tremendous promise in autoimmune conditions esp difficult to treat cases. #eular2025
Dr. Dinesh Khanna@sclerodermaUM

Excited to present data from RESET-SSc in #scleroderma #eular2025. CAR-T was well tolerated with beneficial effects on skin/ FVC. Exciting data on U-M IIS with LN bx showing complete depletion of B cells at 3 weeks and NFC showing normalization of capillary density and size

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