Siyuan Ding

Excited to share the first paper from our lab in 2025! cell.com/cell-host-micr…. Herculean effort by @gaopenghou, the paper demonstrates that UV-inactivated replication-defective rotaviruses can cause diarrhea in neonatal mice.

Happy to share our new manuscript out today in @PLOSPathogens. We showed that in addition to flaviviruses and HTLV-1, rotavirus also utilizes an ER-resident SPCS complex for glycoprotein VP7 signal peptide cleavage and maturation. journals.plos.org/plospathogens/….

@hirasumitk @debajyotic_iisc @iiscbangalore @WashU @Cell_Immunol We are super excited to have Debajyoti join our team! I am sure he will continue to do amazing science and make you proud!

Being an educator for 10+ years, many master students crossed paths, but some stay special. @debajyotic_iisc is one—PhD from @iiscbangalore , now heading to the @WashU USA for postdoc. Before leaving today his visit to @Cell_Immunol was truly a moment to cherish.

Our lab at Washington University School of Medicine is hiring a Senior Research Technician! We are looking for a highly motivated scientist, ideally with animal work experience, to join our enteric virus team! Interested? Apply here: wustl.wd1.myworkdayjobs.com/External/job/W…

We are looking for new colleagues in our department! Come and join our vibrant microbiology community! Please RT.

Great to see our story recognized by the WashU medicine news: medicine.washu.edu/news/researche…

Thrilled to share another paper that came online today in @PNASNews. Enkai in our lab showed that 2-hydroxy very-long-chain fatty acids play an essential role in regulating the entry of viruses and bacterial toxins that commonly rely on endosomal calcium. pnas.org/doi/10.1073/pn…

Gave two talks in the past five days, but the true highlight of the week was seeing Mary Estes introduce Harry Greenberg for the Ruth Bishop Lecture in Cape Town! It’s deeply inspiring to see giants of virology remain so engaged and impactful.

A good read for those interested in mucosal vaccines: wellcomeopenresearch.org/documents/10-5…

Excited to share that I have been promoted to Associate Professor with tenure! Deepest thanks to my past and present trainees, dept chair Dr. Whelan, formal and informal mentors, colleagues, and collaborators for their support over the past six years. I am truly grateful!

A great collaboration with Peter Jackson at Stanford and BV Prasad at Baylor College of Medicine. @WUSTLnews @washumedicine

Happy to share our new manuscript out today in @NatureComms Great effort by @YinxingZhu, the paper demonstrates that the host prefoldin complex positively regulates ISG expression, which rotavirus VP3 protein antagonizes. rdcu.be/eC28K

@XuZhouLab Thank you Xu! Congrats on your pH paper!!

@sding88 Congrats Siyuan! Super cool and interesting finding!

We identified SAMD9 as a common sensor of cytosolic dsDNA and dsRNA molecules and a key host restriction factor of the infection of multiple dsRNA viruses in vitro and in vivo! rdcu.be/eiJHa

@LiuLab4Virology @DermodyLab @washumedicine WashU medicine news on our paper and implications: source.washu.edu/2025/07/washu-…

Great collaborations with @LiuLab4Virology @DermodyLab and many others @washumedicine

Another year of ASV! Really enjoyed Montreal and catching up with friends and colleagues despite the flight delays. Avan from my lab gave a fantastic talk on rotavirus and M cells!

Great opportunity to obtain additional funding and publicity for your work! Don't miss out!

Applications are now being accepted for the Michelson Prizes: Next Generation Grants! We’re seeking applicants who are deepening our understanding of human immunology and uncovering new approaches to combating diseases. All early-career investigators, postdocs, clinical fellows—including residents and interns—and other researchers in training are eligible to apply! Learn more: michelsonmedicalresearch.org/michelson-priz…

Congratulations to Juhee on a stellar thesis defense! Clear, thoughtful, and thorough. Your work on rotavirus and SARS-CoV-2 reflects incredible perseverance. It's been a privilege watching you grow into an independent scientist. Wishing you all the best in your next chapter!🎓👏