Marta Seczynska

Check out this preprint from the Hegde lab. Very nice biochemistry by Szymon Juszkiewicz! biorxiv.org/content/10.110…

Selection on synonymous sites: the unwanted transcript hypothesis go.nature.com/3OqOwVc #Perspective by @SofiaRadrizzani, @kudlalab, @izsvaks_mdc & @Prof_LDHurst @MilnerCentre @TheMilnerInst @UniofBath @mrc_hgu @EdinUni_IGC @EdinburghUni @MDC_Berlin

@wgarland10 @STOPlabPI Agreed, I would also go for piggyBac. That will also give you multiple integrations - rather than a single one in the flipin locus - which will also boost expression.

@STOPlabPI A chimeric intron would generally improve things. We generally use the piggybac system with a chimeric intron for stable integrations.

Dear MolBiol Twitter, any advice? Aim: separation-of-function experiments in human cells. Approach: depletion of endog. protein with dTag + rescue with dox-inducible wt and mutant stably integrated in the FlipIN system. Generated cell lines with the degron and OE, dTag works,

@AkosNyerges @Nature @geochurch @HiTSatHarvard @HMSGenetics @harvardmed @wyssinstitute @SvenjaVinke @implosian @EllieRand3 @baym @BogdanBudnik Amazing work! Congrats Akos!

Today in @Nature we share our work describing • how to achieve resistance to natural viruses, • a technology that prevents the escape of engineered genetic information, • how viruses overcome genetic-code-based resistance. nature.com/articles/s4158…

HUSH makes some noise again! Check out our latest review on the fascinating HUSH complex: we summarize recent insights into HUSH function and discuss its implications for genome evolution and function:

@Faulkner_Lab @Nature Wow, this is quite an honour! Thank you @FaulknerLab & glad you liked it. Perhaps slightly easier to do great work if working on such an exciting topic! HUSH is a really fascinating complex and still a lot to learn about it!

@Nature study dissecting HUSH repression of L1 retrotransposons is my favourite mobile DNA paper of 2022. Tough decision ... this was the "one" for me due to design, execution and importance. And @seczynska answered questions convincingly. Great stuff! nature.com/articles/s4158…

@NavinBrian @Dev_Cell The prospect of using mPGCLCs to study piRNA pathway indeed seemed very attractive, so important clarification on this in vitro model system!

Glad to share my 1st co-1st work from one of my PhD projects with Eric & Azim @Dev_Cell! Hope it’s a useful one: we team with Greg Hannon’s lab to investigate a prior observation of piRNAs in mPGCs in vitro. Alas, we do not detect piRNAs in Day6 mPGCLCs. cell.com/developmental-…

Had an absolutely amazing time at IMP Vienna this week! Thank you Birnstiel Foundation and @IMPvienna for two days of great scientific discussions and networking! photo credit: L. Schedl/IMP

@DevilsAdvoMax @IMPvienna @Cambridge_Uni Thanks Max!

@seczynska @IMPvienna @Cambridge_Uni Wow - big congrats Marta!! Very well deserved, wonderful work!

Very proud to be in the company of such talented scientists across the globe for this amazing award! Thank you @IMPvienna for this incredible honor! Special thanks to my mentor Paul Lehner for his continuous support and @Cambridge_Uni for the nomination.

@LarsMSteinmetz @IMPvienna @Cambridge_Uni Thank you Lars! Very excited to start my postdoc with you soon!

@seczynska @IMPvienna @Cambridge_Uni Congratulations Marta! Well deserved recognition of your amazing work! Looking forward to working with you during your postdoc.

@wszczeklik Dziękuję bardzo! W szczególności za taką świetną promocję na Twitterze 😃

Jeszcze raz serdeczne gratulacje 👏👏👏 Kilka słów o osiągnięciu ! 👇 uj.edu.pl/wiadomosci/-/j…

Absolwentka @JagiellonskiUni - Marta Seczyńska, PhD @seczynska tegoroczną laureatką prestiżowej nagrody Brinstiel! Marta była nominowana przez Uniwersytet Cambridge gdzie niedawno broniła swój doktorat. Serdeczne gratulacje - bardzo się cieszę i życzę dalszych sukcesów ! 1/3

@ch_douse @IMPvienna @Cambridge_Uni Thanks Chris! And likewise - always enjoyed our discussions! Hope you are doing well 🙂

@seczynska @IMPvienna @Cambridge_Uni Congrats Marta! It was always such a pleasure to talk science with you, a real superstar! Good luck in what you choose to do next…

📢Preprint drop! -Are chromatin modifications a cause or consequence of transcription? (or both) How do DNA motifs affect the function of marks? Can combinatorial modifications synergise? We present our epigenome editing study, & unexpected findings👇+🧵 biorxiv.org/content/10.110…

Join our new lab in Lund 🇸🇪! We are looking for a postdoc to lead cool projects on mechanisms of chromatin regulation in human brain development, with a healthy sprinkle of #transposons. Lots of opportunities to learn, develop and drink coffee… Pls RT jobrxiv.org/job/lund-unive…

Ever wondered how cells protect their #genome against #retroelement invasion? Join our impromptu seminar by Marta Seczyńska @seczynska Tuesday 11th January at 10am CET (GMT+1). Marta will talk about her work on #HUSH complex recently published @Nature teams.microsoft.com/l/meetup-join/…

unsere ersten Daten zur Neutralisation von Omicron versus Delta sind fertig: 2x Biontech, 2x Moderna, 1xAZ/1x Biontech nach 6 Monaten 0% Neutralisation bei Omicron, auch 3x Biontech 3 Monate nach Booster nur 25% NT versus 95% bei Delta. Bis zu 37fache Reduktion Delta vs. Omicron

@Faulkner_Lab e.g. based on 'simplified' reporters in Ext Data 3b it is clear that native and codon-opt ORF2 are similarly HUSHed.

@Faulkner_Lab If protein toxic - still more likely ORF2p, as levels of ORF1p from codon-opt do not increase much upon HUSH KO (ncbi.nlm.nih.gov/pmc/articles/P… - Ex Fig. 5G). But yes, this confounds the analysis using L1-GFP 'jumping' reporter. 'Simplified' reporters solved some issues.

Discussed this @nature paper on HUSH at our journal club. Very positive consensus ... important findings supported by well designed science. I wonder though about the prior Wysocka lab result showing an intron was less important than codon optimisation 1/n nature.com/articles/s4158…