Sergio Rius

Redox signaling in the pancreas in health and disease | Physiological Reviews journals.physiology.org/doi/abs/10.115…

New! Online now: Homocysitaconate controls inflammation through reshaping methionine metabolism and N-homocysteinylation dlvr.it/TMk106

New! Online now: RIPK1 senses S-adenosylmethionine scarcity to drive cell death and inflammation dlvr.it/TLYTBr

Itaconate modulates immune responses via inhibition of peroxiredoxin 5 go.nature.com/3RsJokJ

RESEARCH | AM Casey, MP Murphy et al. (U Cambridge): The study explores the basic mechanisms of superoxide production in #mitochondria and its impact on interleukin-1β production in LPS-treated macrophages 🧫✨ nature.com/articles/s4225…

Review in @physiolrev by @ser_rius & co-authors discusses #OxidativeStress and #redox signaling in the #pancreas under healthy physiological conditions as well as in acute #pancreatitis, chronic pancreatitis, #PancreaticCancer, and #diabetes. ow.ly/EphK50VmvUf

#NatMetabPicks | In @CellCellPress led by JB Spinelli (@UMassChan) Rhodoquinone carries electrons in the mammalian electron transport chain. cell.com/cell/fulltext/…

🔬Researchers Chadha, Khurana & Schmoller from @HelmholtzMunich explore the link between #CellSize & cell function in this innovative review. Discover more: ow.ly/NtzK50TN2mL

Subcellular mitochondrial heterogeneity enables opposing metabolic demands: Trends in Endocrinology & Metabolism cell.com/trends/endocri…

Join our research team at University of Barcelona! We are looking for candidates to apply for a PhD position focused on mitochondria, aging and metabolism. 💡 Requirements: Academic grade >8 📅Deadline: Feb 14th If you are interested, contact me by DM ub.edu/beques/3rcicle…

The bidirectional transfer of mitochondria between cancer and immune cells is a newly discovered mechanism that thwarts anticancer defences go.nature.com/3WyCUnb

Another amazing piece of work from @ShivKSingh6 lab with @BarbaraGrnwald 😃 As always, crazy amount of data and provocative results!! Kudos to the team 👏👏. Honored to have contributed a small piece. Don't miss the thread and of course the paper!

Mitochondrial segmentation and function prediction in live-cell images with deep learning | Nature Communications nature.com/articles/s4146…

📰 Very proud of our work published in @NatureComms. We demonstrate that muscle and liver NAD+ depletion in cancer #cachexia can be reversed using the NAD+ precursor #niacin (vitamin B3), ameliorating muscle wasting and improving mitochondrial metabolism. nature.com/articles/s4146…

This has been needed for a long time! Redefining obesity A new report of @TheLancetEndo commission that overrides current BMI categories and better defines features and pathophysiologic consequences of pre-clinical and clinical obesity thelancet.com/journals/landi… open-access (such as an athlete with no fat excess is not obese, but is according to current BMI based definition)

New! Online now: Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1 dlvr.it/THP5Hz

Special Issue Invited ECR Review article ‘p53 at the crossroad between mitochondrial reactive oxygen species and necroptosis’ sciencedirect.com/science/articl…