Shankar Dutt

Just launched my new personal website and I'm really happy with how it turned out 🌟 I work on AI-integrated nanopore biosensors at ANU If you're into biosensing, nanotech, or ML for diagnostics — come say hi: 🔗 duttshankar.com

(2/2) What we found: a disease-linked tRNA mutation traps the RNA in misfolded states. Backed it up with cryo-EM and synchrotron X-ray scattering. 3 million molecules. Three techniques. One story: RNA shape matters. Incredible collaboration across Australia 🇦🇺, USA 🇺🇸 & Poland 🇵🇱

(1/2) Just published in Nucleic Acids Research! One nucleotide. One mutation. Neurodegeneration. We employed nanoscale sensors to watch RNA fold in real-time — molecule by molecule. 📖 academic.oup.com/nar/article/54… #Nanopores #RNA #Biosensing #CryoEM #SAXS

@CranfordMATTER @amazon You should consider getting a Mac. With the new Macs, I can easily travel for a few days without needing an adapter.

Setback when I absent-mindedly forgot my laptop cord when heading to #S24MRS. I figured it was a pretty safe bet to have one over-nighted to the hotel from @Amazon... considering I'm in Seattle! Prime saved the day (and manuscript handling)!

@JodieBradby @Pat_Oz68 @materials_anu Sounds like a plan!!! @Pat_Oz68 we need to make some for those night shifts 😂

PS @Pat_Oz68 @shankar_phy @materials_anu - the Swift Heavy Ions Irradiation group should really get on board with this trend! 😂

Join us at @PhysicsANU during @ourANU #ANUOpenDay on March 16th to weave science into every loop! Craft your very own glow-in-the-dark friendship bracelet and ask us all about Physics. Hope to see you there!

NanoPlex: a fast analysis application to extract and analyze solid-state nanopore traces is now available online. The pre-print is out and can be accessed through: chemrxiv.org/engage/chemrxi…

The program for the ANZCOP-AIP Summer meeting is out! aip-summer-meeting.com 🤝 Looking forward to the morning yoga, industry networking, discussions on the new Australian Science Priorities (Shine Dome), ChatGPT chats, equity events, & company exhibit. Registrations open now!

4/4 This fusion of these two technologies may also open up new avenues for health diagnostic applications, where proteins serve as crucial biomarkers. @Pat_Oz68 @Nano_Nuwan @BKarawdeniya @PhysicsANU

3/4 Using nanopores fabricated in <10 nm thick silicon nitride membranes and leveraging high bandwidth instruments, we have realized F-values and specificity up to 88.7% and 96.4% respectively, in identifying combinations of four similar proteins.

1/4 I am excited to share our latest publication in Small Methods, “High Accuracy Protein Identification: Fusion of Solid-State Nanopore Sensing and Machine Learning”. doi.org/10.1002/smtd.2…

Congratulations to @materials_anu 's @ShaaaaronHuang for winning a poster prize at the recent #iucr2023 👏💪

I am deeply humbled to receive this award. A big thank you to @Pat_Oz68 and team @materials_anu for their unwavering support!

@Sajeerp_ Not a bad idea, if we can make the nanopore linked with the quantum well inside the material... What do you and others think?

Is anyone in nanopore community interested in making #LK99 based solid-state nanopores for sensitive and accurate protein sequencing😜? #nanopore #nanoporecommunity #solidstatenanopore #fun #superconductor

@CranfordMATTER Also need to publish a three author paper before those 60 days end… how are the publication times at Matter?

Considering all the #LK99 excitement this week, if your lab had, say, 60 days of magic and no experimental or synthesis attempt could fail*, what would you work on? *anything goes - alchemy, cold fusion, superconductivity, unobtainium permissible, unlimited resources

@CranfordMATTER Vibranium and Uru Then give them some superconductivity because why not :P

@JodieBradby That’s amazing!! Congratulations to the team…

Big week in the lab.. smashed a few local records (and ok a few diamonds!). But look at our happy faces. These were our last few pressure steps (took a group pic each time in case it was the last).

8/8 Conclusively, our study shows that antioxidant content has a profound impact on the ion track structure and the degradation of the foil. The research opens up new perspectives on the interaction between swift heavy ions and polymer materials with different content.

7/8 Interestingly, the size of these ion tracks directly correlates with energy loss, indicating a strong relationship between energy deposited by the incoming ion and the ion track size/structure. #Physics

1/8 Excited to share our #research paper "Role of Antioxidants in Swift Heavy Ion Tracks in Polypropylene" published in Polymer. Here we examine how different antioxidant concentrations impact ion tracks created in polypropylene foils. #PolymerScience 🔬 sciencedirect.com/science/articl…