Morgan et al., Science Adv (2023) science.org/doi/10.1126/sc…
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Shilatifard Lab
411 posts
Shilatifard Lab
@ShilatifardLab
The goal of our laboratory is to define the molecular mechanisms underlying cancer pathogenesis and to identify potential targets for therapy.
Chicago, Illinois Katılım Ekim 2022
156 Takip Edilen1.1K Takipçiler
For 15+ years, our work has shown that histone-modifying enzymes do more than just their catalytic jobs. They also have important non-catalytic roles. Dr. Zibo Zhao just published a great review on COMPASS family enhancer monomethylases and discusses how their loss creates new druggable vulnerabilities. nature.com/articles/s4156… Her findings are now in the clinic for treatment of cancers bearing MLL3/4-COMPASS mutations Fingers crossed! @NU_BMG_SQE @NUFeinbergMed @theNASciences @theNAMedicine @CellPressNews @ScienceMagazine @Nature @NatureCancer @MolecularCell @zhao_zibo
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Congratulations, Jindan. Your Northwestern Biochemistry/Molecular Genetics colleagues are very proud of you!
Jindan Yu, MB, PhD@yu_jindan
So glad to become a member of AAP. With my nominator and sponsor @jdlicht
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God bless E. Donnal Thomas! Met him many years ago. A wonderful individual.
Ankit Bharat, MD FACS@AnkitBharatMD
A man in Norway has been effectively cured of HIV after a stem cell transplant from his brother. The "Oslo patient" is now in full remission with no medication needed. He is the 7th person in history to achieve this outcome. (Announced today)
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The SQE Inspire Program hosted 7th Grade students with the Ladies of Virtue program today for a STEM field trip learning about cancer research and some of the techniques used! @NU_BMG_SQE @NUFeinbergMed #STEM
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Shilatifard Lab retweetledi
Congratulations to Dr. Lillian Eichner @EichnerLab on being a Cancer Research Foundation Young Investigator Award Recipient! @CancerRF @CRFcharity @NUFeinbergMed #LungCancer #Cancer cancerresearchfdn.org/recipient/lill…
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Shilatifard Lab retweetledi
Join us today for the BMG Journal Club Presenter David Lowe! @ShilatifardLab Refreshments will be provided.
@NUFeinbergMed #research #epigenetics #CRISPR
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Amazing evening spent with Sir Richard J. Roberts and colleagues at New England Biolab, discussing, molecular biology, splicing, science and wine! Thank you Sriharsa for hosting a great visit for me. @NU_BMG_SQE @NUFeinbergMed @NEBiolabs
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Behold the awesome power of biochemistry & molecular genetics in advancing medicine! Thrilled to share that our committee for the BBVA Prize in Medicine has selected Drs. Carl June @carlhjune and Michel Sadelain for revolutionizing cancer therapeutics through genetically engineered CAR-T cells. Congratulations Carl and Michel — we look forward to celebrating with you in Bilbao soon! @NU_BMG_SQE @NUFeinbergMed @theNASciences @theNAMedicine @CellPressNews @ScienceMagazine @Nature @NobelPrize @FundacionBBVA @ColumbiaPS @Columbia @PennMedicine @Penn
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In majestic Madrid, Spain, the BBVA Foundation Frontiers of Knowledge Committee on Medicine gathered to select the 2026 awardees. Announcement later this week—stay tuned! @NU_BMG_SQE @NUFeinbergMed @theNASciences @theNAMedicine @CellPressNews @ScienceMagazine @Nature @NobelPrize @FundacionBBVA
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It was great to spend the day with superb colleagues at National Cancer Advisory Board study group and discuss how to spend taxpayers money for better cancer research, therapeutics/treatment and care! @NUFeinbergMed @NU_BMG_SQE @theNCI @NIH @theNASciences @theNAMedicine
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Shilatifard Lab retweetledi
@ShilatifardLab we are looking forward to your presentation at our #FusionEpigenetics meeting in Portugal this October 🇵🇹
Please share this with your followers to let them know you will speaking, and to register & submit today to join us!
🔗bit.ly/4c86YhZ
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Shilatifard Lab retweetledi
Join us today for the BMG Faculty candidate speaker Dr. Gokhan Unlu! Hosted by Dr. Ali Shilatifard and Dr. Issam Ben-Sahra. @ShilatifardLab @bensahralab #epigenetics #Cancer #research @NUFeinbergMed
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Shilatifard Lab retweetledi
How do TATA-less promoters recruit TFIID—and why does it matter for BET-targeted therapeutics? A groundbreaking study by Northwestern University School of Medicine Fienberg Fellow Dr. Bin Zheng reveals a distinct and essential role for BRD2 in transcriptional control. cell.com/molecular-cell… The work shows that BRD2 bromodomains selectively bind MOF-mediated H4K16ac, while its C-terminus recruits TFIID to initiate transcription at promoters and enhancers. In contrast, BRD4 primarily regulates transcriptional elongation in a BET-domain–independent manner. These findings redefine functional specificity within the BET family, demonstrating that BRD2 and BRD4 act at different transcriptional steps and that their BET domains are not interchangeable. Congratulations to Bin on this exceptional body of work, which uncovers key limitations of BET inhibitor–based therapies and significantly advances BET family–targeted therapeutic strategies. @NU_BMG_SQE @NUFeinbergMed @theNASciences @CellPressNews @MolecularCell @ScienceMagazine @Nature @NatureGenet @pfizer @JNJNews @Merck @EliLillyandCo @abbvie @Amgen @biogen @Novartis @AstraZeneca
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