Simplify Genomics

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Simplify Genomics

Simplify Genomics

@smart_genome

Simplify Genomics, Inc. is a genomics technology company that has built an analytical and interpretation platform to empower genomics in healthcare.

United States Katılım Ekim 2023
51 Takip Edilen149 Takipçiler
Simplify Genomics
Simplify Genomics@smart_genome·
@patrickc @DanteLabs Appreciate the mention and pleased you had a good experience! While we’re not DTC, we take exceptional care in the quality of the genomic results and interpretations we deliver. Expanding our physician network to streamline ordering is a big focus for 2026—more to come.
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Patrick Collison
Patrick Collison@patrickc·
By the way, I don't know of any great, easy-to-recommend D2C consumer genome sequencing service. Are there any good ones? (We tried @DanteLabs, but never actually got the sequenced genome back, and never heard back from customer support. I encountered someone else who also had this experience with them. @smart_genome ended up working well, but I think they require going through a clinician.)
Patrick Collison@patrickc

I'm lucky enough to have a great doctor and access to excellent Bay Area medical care. I've taken lots of standard screening tests over the years and have tried lots of "health tech" devices and tools. With all this said, by far the most useful preventative medical advice that I've ever received has come from unleashing coding agents on my genome, having them investigate my specific mutations, and having them recommend specific follow-on tests and treatments. Population averages are population averages, but we ourselves are not averages. For example, it turns out that I probably have a 30x(!) higher-than-average predisposition to melanoma. Fortunately, there are both specific supplements that help counteract the particular mutations I have, and of course I can significantly dial up my screening frequency. So, this is very useful to know. I don't know exactly how much the analysis cost, but probably less than $100. Sequencing my genome cost a few hundred dollars. (One often sees papers and articles claiming that models aren't very good at medical reasoning. These analyses are usually based on employing several-year-old models, which is a kind of ludicrous malpractice. It is true that you still have to carefully monitor the agents' reasoning, and they do on occasion jump to conclusions or skip steps, requiring some nudging and re-steering. But, overall, they are almost literally infinitely better for this kind of work than what one can otherwise obtain today.) There are still lots of questions about how this will diffuse and get adopted, but it seems very clear that medical practice is about to improve enormously. Exciting times!

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Simplify Genomics
Simplify Genomics@smart_genome·
A recent discovery (nature.com/articles/s4159…) highlights the importance of studying rare APOE variants in Alzheimer’s disease. Watch how we use our Smart Genome platform to query for the presence of this rare protective variant, c.460C>A (p.Arg154Ser). youtu.be/9GBsFUr9l3E
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Simplify Genomics
Simplify Genomics@smart_genome·
Simplify Genomics has been interpreting whole genomes for over 10 years, initially operating within @humanlongevity and now independent. Consider our milestones when selecting your whole genome partner for hereditary risk, pharmacogenomics, polygenic risk, and wellness traits.
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Simplify Genomics
Simplify Genomics@smart_genome·
Approximately 25% of US adults take statins for lipid management. We find that ~30% of patients surveyed have non-normal function for SLCO1B1, which can predispose patients to an increased risk of myopathy. Knowing your patient’s SLCO1B1 function can help you manage side effects.
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Simplify Genomics retweetledi
GenomeWeb
GenomeWeb@GenomeWeb·
Simplify Genomics Eyes Preventative Testing Market with Automated Genome Reporting Platform. A spinoff of personalized health company Human Longevity, Simplify Genomics came out of stealth mode last month and is currently "hyper-focused" on the... ow.ly/eug5105kb5c
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Genetic Engineering & Biotechnology News
Human Longevity Spin-Out Aims to Tap into Variant Interpretation Market Simplify Genomics recently emerged from development mode with the launch of Smart Genome, a proprietary genome interpretation, analysis, and reporting engine. Learn more: ow.ly/KxGm50QwkIz
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