Eric Sobie

RASopathy-associated multifocal atrial tachycardia was modeled with HRAS-mutant iPSC-derived atrial cardiomyocytes, providing mechanistic insights #AHAJournals #Epeeps @glennfishman @sobielab @rdariolli doi.org/10.1161/CIRCEP…

@EM_RESUS Really great video. I'm not a cardiologist, only a basic science electrophysiologist who teaches the basic principles. It's great b/c the ST elevation/depression is much more subtle than in the textbooks. But consistent across many leads.

Here’s a very important video I made breaking down this #ECG case of a 30-year-old man who collapsed into cardiac arrest #FOAMed

@GradSchoolSinai student DeAnalisa Jones, part of the @SinaiDoubleDocs program, featured by the Journal of General Physiology at the 2023 @BiophysicalSoc meeting Great pic!

Current, former, & future members of ISoP Quantitative Systems Pharmacology SIG at #ACoP13 Thanks to @stacey_xmastree they really know how to throw a good party boothpics.com/X7IZ/0b7ase

@MichaelClerx I never considered applying this terminology before, but one could argue that the Fitzhugh and Nagumo models were digital/analog twins, respectively? Of course van der Pol is an even more old-school reference, credit for that

EXCITED to have the Center for Scientific Diversity's (@Sci_Diversity) Leadership speak at our #DiverseBrains event THIS MONDAY! JOIN US as @EKTBenn @ClarkNeuro @DrJamiliaSly & @tracymlayne present “Why is systemic racism bad for science?” REGISTER👉bit.ly/3SzTJdF

I'm excited to welcome Dr. Jinye Dai as my new next-door neighbor at Mount Sinai! Look for lots of exciting work from her group in neurophysiology & neuropharmacology.

Are you considering obtaining a PhD in Biomedical Sciences in an innovative environment? Join me and @sobielab on Mon Sep 26 at 4pm ET for a webinar describing our Pharmacology and Therapeutics Discovery training area at @GradSchoolSinai @IcahnMountSinai bit.ly/3qYbHdA

A happy occasion today as our new PhD students in pharmacology at @IcahnMountSinai received their lab coats today at the annual lab coat ceremony. With co-director @SchlessingerLab

Very happy to see our special issue, Quantitative Approaches to Drug Safety, in print at CPT PSP. ascpt.onlinelibrary.wiley.com/toc/21638306/2… Coming from the Torsades prediction world, it's cool to see a variety of approaches used to understand a wide range of adverse events. @ASCPTjournals

@rita_strack As reviewer, also stressful to see the others True story: J Mol Cell Cardiol used to ask for rating 1-100 Didn't like a paper, gave mediocre number. Other reviewer gave same number! Revision slightly improved. Number up a little bit. Other reviewer-- same number again!

I've been an editor for seven years, and I still get nervous right before I read the reviews of your papers.

@frettinglab @HColecraft @BiophysicalSoc @BiophysJ Wow, awesome news, Congrats Henry!

@teunpdeboer Thanks Teun! That paper is a good one to examine in more detail

@sobielab Not an exact answer, but Martin Rook showed synchronization of neonatal rat CM by pushing 2 single cells together. Only a few GJ channels were required for syncing. pubmed.ncbi.nlm.nih.gov/1279981/

Rather than dig into Methods sections of papers I read several years ago, let me try this platform What is the best value for gap junctional resistance between two adjacent *SA nodal* myocytes. I would say ~2 MOhm for ventricular, but for SA node?

@emilia_entcheva Awesome, thanks Emilia, I remember reading those papers several years ago, but couldn't remember the numbers. Happy Thanksgiving!

@sobielab Hi Eric, 1994 Cai et al, computationally claim 50nS for freq + waveform entrainment; 0.2nS for freq. only entrainment PMID: 8045574. 1998 Verheijck et al experimentally find 10nS for freq + waveform entr., 0.5nS for freq only entrainment PMID: 9417138

Should've shared this when it came out a month ago, but I'm thrilled that our publication combining modeling with machine learning to understand inter-individual differences was published in PNAS. Congrats to Meera & Xueyan!! pnas.org/content/118/37…

@NVandersickel @ugent @ugent_fwe I agree it's great to be in person again, but teaching "hybrid," where things are simultaneously on Zoom, is really challenging ... .... especially when teaching MATLAB to people with no experience coding!

Back to teaching in person, great to see the students again! One positive change due to #corona: students can completely chose how they follow biophysics: in person, hybrid or online. @ugent @ugent_fwe

@Madison_B_Nowak @SHWeinbergLab Congrats, Madison! Where to next?

@ele_grandi_ I did the same and they also gave us until February 5, it sounds like that's pretty standard.

@sobielab We emailed and got an extension to Feb 5 (I think). Still too early, but better...

Question for folks who attend Biophysical Society: How are you handling the deadlines they are issuing for the virtual meeting? One month ahead of time seems ridiculous & folks in my group are freaked out. Is there any push back or renegotiation of these deadlines?