Aaron

Excellent thread.

Ditto Bio looks particularly promising.

There is a startup pictorlabs.ai doing something like this without overselling it the way Microsoft is doing here.

Also worth noting that the number of registered clinical trials for mRNA vaccines in China is way higher than in the US.

Pixar is F*ed

ROFL

this is alive. 800,000 living human neurons are about to play video games. For real. Not Artificial Intelligence — Organic Intelligence. Something is booting up. 🧠⚡

The prompt to nano banana was: "Please make a fake movie promotional poster for a movie called "A Very Sus Engagement" The poster should be a closeup shot of a woman who resembles Sabrina carpenter looking up lovingly at Blippi who is looking lovingly down at her. It should be photorealistic. Her hand should be resting on his cheek as if she is about to kiss him. Their gaze should show love and passion. The Tuscan countryside should be in the background."

So excited for this film!

@MichaelAlbertMD I do an unpasteurized water buffalo milk, acai and compounded Ziconotide smoothie every morning after my cold plunge.

The Peptide Wild West RFK Jr. wants to make them easier to get. Wellness influencers won't stop talking about them. Here's what the human evidence actually says. Part 1: Link → substance-over-noise.beehiiv.com/p/the-peptide-… #peptides

@MichaelAlbertMD cone snail venom is a peptide

Peptides are the NFTs of wellness.

This is the most personal thing I've published. I've been taking low-dose tirzepatide for 2 years. Not for weight loss. Not for diabetes. I'm a physician who made a calculated bet on the multi-organ potential of this drug class. I know how some colleagues will read this. I know exactly how the internet will reduce it: "Doctor admits to using Ozempic for productivity." That's not what this is. But staying silent felt worse than being misunderstood. ⚠️ I don't endorse others doing what I've done — my clinical background affords a level of informed consent that most people don't have. Full piece → substance-over-noise.beehiiv.com/p/special-edit…

Thank you monitor lizards!

@davidycli They are leading in mRNA cancer vaccine trials.

the first in class, first in human data coming out of China in novel modalities (esp in vivo CAR-T, RNA therapies, gene therapies) in the coming 18 months will shock the world.

Bad Santa Part 3

@jhuber For what it's worth, I'm a super fan of the GRAIL team. Thank you.

The NHS-Galleri trial results came out last Friday. 142,000 participants. 3 years. The most ambitious cancer screening trial ever run. The headlines: primary endpoint missed. That's a fact, and it matters. But I believe the headlines are missing the deeper story in these data – one that matters enormously to patients and to the future of cancer screening. Here's what the NHS-Galleri Test study showed: ✅ Stage IV cancer diagnoses – metastatic, typically incurable disease – declined substantially in the screened group, with >20% reductions across the 12 deadliest cancer types ✅ More cancers were found at Stage I & II, when treatment can be curative, in cancers that are typically diagnosed late (pancreatic, ovarian, liver, lung) ✅ 4x higher overall cancer detection rate when Galleri was added to standard screening (i.e., colonoscopy & mammography) ✅ Fewer cancers detected through emergency presentation – the worst possible way to learn you have cancer, and the most lethal and most costly ✅ No serious safety concerns. Test performance consistent with prior studies (with very high 99.5% specificity and very low false positive rate) So why did the 'primary endpoint' miss? See article for more detail & perspective on the study design, and the 'Stage Migration paradox' that masks enormous progress and clinical impact for patients.

We went to LA and saw some things. Get on your knees.

I had him taken out for stealing my nickname.

@matthewherper This study does indeed appear flawed, but there are a bunch of studies showing that morning vaccination is superior to afternoon vaccination which I'd argue is supportive of the overall concept. scholar.google.com/scholar?hl=en&…

Study on timing cancer treatments to the morning comes under fire statnews.com/2026/02/20/can…