Sean Langan, PhD

Found out some new features on Substack where you can customize your website (they're not actually new, but are new to me). If you're interested in human performance science (including health, nutrition, medicine, etc.), shoot me a subscription 🙏🫡 seanlangan.substack.com

@themovementDrZ 😂

Taking 15 shots and a whole bottle of new Amsterdam to being DIALED

Intervals are always going to be hard, but by adding some variability in the power output within each interval, you may to be able to get more bang for your buck. Read more at the link below. @seanlangan/note/p-185266481?utm_source=notes-share-action&r=28euut" target="_blank" rel="nofollow noopener">substack.com/@seanlangan/no…

Cool study on mitochondrial calcium and aging in skeletal muscle. I suspect research on novel polyphenol compounds is only going to keep growing in the next few years. cell.com/cell-metabolis…

What makes VO2max relevant to health? seanlangan.substack.com/p/what-makes-v…

Favorite road race. 2nd mile is always a kick in the teeth. Think I’m still capitalizing on the newbie gains. 2min faster than 2023. Next goalpost <26min.

well - try to ingest 120 grams of CHO (with ½ glucose and ½ fructose) and see what happens (just resting)

Our latest work: "Sprint interval exercise disrupts mitochondrial ultrastructure, driving a unique mitochondrial stress response and remodelling in men" has been accepted in Nature Communications and will soon be online 😊

This might surprise you about blood testing. One reason it has gotten so much cheaper is that many companies have shifted towards using prediction equations. So those 40, 80, or 120 biomarkers "you're paying to get tested" ....are not actually being measured. This ranges from awful to awesome. E.g., Free testosterone is rarely directly measured. Been like that for decades. Cool. The issue is not all blood testing facilities use the same equation (there are multiple validated ones) - so you might be 'going up' or 'going down' simply because of switching providers. Futhermore, if you ever get direct free test measured, it will likely differ greatly from your predicted values; confusing the crud out of you. Again, nothing new here. What has changed is the expansion to numerous other markers, based heavily (if not entirely) on the company's own algorithm. i.e., NOT on externally validated equations. This becomes a huge issue because: 1. Customers are being deceived (overtly and covertly) 2. The prediction equation can be hugely erroneous, especially if you are outside of the reference population the company used to build it (which we don't know because they haven't externally validated it yet). Obviously, I have a major COI in this space, so interpret that however you will, but people should know this is happening and can make whatever decision with that information they choose. Happy Wednesday!

@stevemagness How about we let people do what they want? Do you need to obsess over VO2max to get faster? No. Is it a relevant health metric? Yes. Why do you care the health data other people want to know? Strange clickbait take.

Hot take: Vo2max is overused. Most people shouldn't measure or focus on. And most shouldn't aim for improving it. It will improve with good training in novices. And for advanced, it's not a worthwhile measure to chase. Focus on improving performance, not parameters.

@beantownsox @concept2 Haven’t used Zwift, but the bike erg is great I use it all the time

@spl5_ @concept2 Have you messed around with Zwift at all this year? I’d love to add the bike erg to my rower that I got a few months ago.

Huge fan of @concept2 equipment. Just added the bike erg (in addition to the rower). Durable as hell. Having some equipment at home has been the biggest game changer for my fitness over the last year or so. So easy to fit in extra volume and pissed I hadn't done it sooner.

New review article published on the effects of heat on the skeletal muscle microvasculature authors.elsevier.com/a/1m67O15hXuJz…

@FelipeGorini authors.elsevier.com/a/1m67O15hXuJz…

@spl5_ Looking forward to reading this!

Very pumped for this come out. Consumed lots of brain power over the last year. 💪🔬🔥

Congrats to Sean P. Langan et. al, for the #APSselect paper "Hypoxia-induced impairments in fasting glucose are associated with acute mountain sickness severity during four days of residence at 4,300 m" in @AJPRegu @spl5_ @TeamUSARIEM ow.ly/hCNP50XpsoT

@umirf1 @jamiepersonaI 🤣

@jamiepersonaI Bro said go for a long walk

It's probably a dumb question but how does someone get into and do running properly. Can't just be as simple as go outside and run, right? Best practices/advice. Have always just done sports for exercise.

Consistent with all previous cases, my sleep parameters show full recovery after illness before my standing values. I’m not expressing confusion, I’m highlighting greater sensitivity of standing HRV.

Before your next mountain weekend, check out this #ResearchArticle from Langan @spl5_ et al: Hypoxia-induced impairments in fasting glucose are associated with acute mountain sickness severity during 4 days of residence at 4,300 m ow.ly/TECe50XmUux

@FelipeGorini I'll be sure to send it over!

@IntraRunner 😂

Many runners aren’t plugged into how the influencer world works. Let me help: They take common things that runners have done for decades then mysticize it and package it into a fun/novel concept.

Next hot fad in running: “overnight doubles”. Run PM—>sleep—>Run AM—>Run PM 3 runs in 24 hours. Expect to see influencers talking about this in the next few months.

@brady_h RPE >

If you are running a pace that feels very easy but HR is above “zone 2” range, then your zone 2 HR range is probably higher than you think.