Stem Protocol

@Under_DeSci If it's about signaling then injecting a few cells won't matter because they will acquire the host phenotype. If it's about the cells then signaling won't mater. It's likely the signaling, and the implanted cells give off some exosomes and other factors before they are rejected.

@stem_dao Couldn't it be both? Old cells might not respond to young signals, and young cells might struggle in an old environment.

Stem cells vs. exosomes therapy isn’t just a technical debate. It’s a bet on what aging really is. If young cells reverse aging → aging is cell intrinsic. If young signals (exosomes) reverse aging → aging is cell extrinsic.

Scientists Reversed Aging in Monkeys. Humans Could Be Next Scientists demonstrated that senescence resistant mesenchymal progenitor cells (SRCs), engineered with the longevity gene FOXO3, can not only halt aging but partially reverse it in aged macaques. 👀 Intravenous SRC treatment improved cognition, bone strength, and reproductive health without adverse effects. Mechanistically, SRC derived exosomes reduced cellular senescence markers (p21CIP1, γH2AX), inflammation (IL-1β, TNF-α, IL-6), and oxidative stress, while enhancing heterochromatin stability (H3K9me3, lamin B1) and immune function. This suppressed the cGAS-STING inflammatory pathway and promoted systemic rejuvenation. This research suggests aging is not just inevitable decline but a treatable condition. SRCs outperformed conventional stem cells, reversing multiple hallmarks of aging across organ systems. The findings offer a proof of concept for human anti aging therapies.

A major step toward rejuvenation and longevity Chinese researchers have presented an anti-aging therapy using genetically modified stem cells in Cell, which was tested in a 44-week trial on macaques. The so-called senescence-resistant cells (SRCs) were injected every two weeks without side effects or tumor formation. The result: systemic rejuvenation across ten organ systems, from the brain to the bones. Cognition, fertility, and tissue regeneration improved measurably, and some markers of aging were reversed. The effect appears to be mediated primarily by exosomes, which reduce inflammation and stabilize cells—a possible new key to holistic age reversal.

Many are betting on a the idea that signals from young cells can rejuvenate or “reset” old ones

StemDAO：利用干细胞疗法推动长寿与再生医学 @stem_dao 是 @BioProtocol 上的一个社区驱动项目，专注于支持干细胞疗法在长寿和再生医学领域的研究与开发。干细胞因其独特的再生能力，被认为是延缓衰老、修复组织和治疗多种疾病的关键技术。 通过区块链和 STEM 代币，社区成员可以为研究提供资金，参与投票决定研究方向，并推动前沿疗法更快地走向大众。STEM 代币不仅是一种支持工具，也是一座桥梁，把患者、科学家和投资者紧密联系在一起。 StemDAO 还致力于解决传统科研中的障碍，例如专利壁垒和缓慢的审批流程。它通过开放透明的机制，让科研成果能够被更多人共享，加速新疗法从实验室走向临床应用。 这意味着患者有机会更快接触到突破性疗法，科学家能够获得来自社区的直接支持，投资者也能在推动医学进步的同时共享价值。 简而言之，StemDAO 正在利用去中心化科学的力量，加速干细胞研究的创新，把健康与长寿的未来带到每个人的身边。 如果你想进一步了解，可以访问: app.bio.xyz/launchpad/Stem…

@kashyneth Through the nose → across the permeable olfactory barrier → into the brain. Exosomes don’t necessarily need needles.

@stem_dao please advise how does it actually work?

Forget pills. Forget injections. The future of anti-aging goes through your nose.

We just got back from Taiwan. It’s bursting with exosome labs. Exosomes are already a cosmetic commodity. Do they actually work, and for what? We'll find out.

@bryan_johnson What the hell are "exosomes"?

A paralysed man can stand on his own after receiving an injection of neural stem cells to treat his spinal cord injury go.nature.com/41ZCoRj

Best answer in the replies gets a reward 👇

Hey, anon. Yes, you. Do you know what a stem cell is, actually?

87% of surveyed StemDAO community members prefer EVM (i.e. @Ethereum, @Base) over @Solana. What do you prefer?

@le_mec 🦾

Polimec: Everyone is a VC

That's a paper we like. Restoring hypothalamic stem cells in mice extends lifespan, partly through exosomal miRNAs that decline with age. nature.com/articles/natur…

@bryan_johnson The jury's still out. Other factors like age of donor, growing conditions, and therapeutic context (what you're targetting) may prove more significant than the source cell lineage.

@MycoDAO @discord ok

Join us on @discord discord.gg/srr3tJBExX

@zacxbt correct

Once you go DeSci you never go back

@le_mec gm

gm☕️