stephen mchugh

Our new study is out in @NeuroCellPress: “Offline hippocampal reactivation during dentate spikes supports flexible memory”, with David Dupret and fantastic group at @MRCBNDU, @NDCNOxford authors.elsevier.com/sd/article/S08… #NeuroTwitter #hippocampus #pubalert 🧵 (1/9)

Im pleased to share our new work, “Spatio-temporal organization of network activity patterns in the hippocampus”, now out in @CellReports! With Demi Brizee & David Dupret, we track how rhythms and spiking behavior map onto hippocampal layers. doi.org/10.1016/j.celr…

Excited to share our preprint led by @ainchung & Jason Alipio showing how few immature adult-born DGCs preferentially recruit inhibition of CA2 and CA3 to disproportionately affect hippocampal network properties and social memory. We began by asking 1/n biorxiv.org/content/10.110…

Why academia is sleepwalking into self-destruction. My editorial @Brain1878 If you agree with the sentiments please RT. It's important for all our sakes to stop the madness academic.oup.com/brain/issue/14…

Hippocampal ripples during offline periods predict human motor sequence learning. Work led by the brilliant @PinChun_Chen. biorxiv.org/content/10.110…

@HelenCBarron @NeuroCellPress @MRCBNDU @NDCNOxford Thanks Helen!

@stephenmchugh6 @NeuroCellPress @MRCBNDU @NDCNOxford Congratulations Steve !

Our new study is out in @NeuroCellPress: “Offline hippocampal reactivation during dentate spikes supports flexible memory”, with David Dupret and fantastic group at @MRCBNDU, @NDCNOxford authors.elsevier.com/sd/article/S08… #NeuroTwitter #hippocampus #pubalert 🧵 (1/9)

Interested in the utility of EEG for early / differential diagnosis of dementia? Check out latest preprint from our unit (tinyurl.com/22xrzaz4): medrxiv.org/content/10.110…

@marco_bocchio @NeuroCellPress @MRCBNDU @NDCNOxford Lovely to hear from you! Hope that Durham is treating you well. Invite me to give a talk!!

@stephenmchugh6 @NeuroCellPress @MRCBNDU @NDCNOxford Congrats Steve! Great study and great thread! Hope all is well

@DrewBHeadley @NeuroCellPress @MRCBNDU @NDCNOxford Thanks - your 2017 manuscript influenced my decision to investigate dentate spikes in the first place.

@stephenmchugh6 @NeuroCellPress @MRCBNDU @NDCNOxford Very cool! We need more work on dentate spikes.

@jjsakon @NeuroCellPress @MRCBNDU @NDCNOxford Thanks for your interest. DS rates are 0.4Hz when mice are sleeping/quietly resting (more details in 1st para of results: (median [IQR] occurrence frequency: DSs = 0.40 [0.25–0.58] Hz; SWRs = 0.75 [0.26–1.26] Hz).

@stephenmchugh6 @NeuroCellPress @MRCBNDU @NDCNOxford Hi Stephen, glanced through the paper and very intriguing signal y'all found. And seems rather simple to detect too! I didn't see anything about DG spike rates (only a bit in methods about total spikes in a recording session). What are typical rates on a single DG-localized elec?

Temporal structure of experience etched on firing of human hippocampal-entorhinal neurons to serve memory & prediction. See our study @Nature at @UCLANsgy, great work by lead author @PTacikowski with @GuldamlaKalendr & @DavideCili support @NIH_NINDS. nature.com/articles/s4158…

@LauraGrimaNeuro @NeuroCellPress @MRCBNDU @NDCNOxford Thanks Laura - hope all is good with you!

@stephenmchugh6 @NeuroCellPress @MRCBNDU @NDCNOxford Congrats Steve, lovely work!

@lindaktna @NeuroCellPress @MRCBNDU @NDCNOxford Thanks Linda - hope you are well.

@stephenmchugh6 @NeuroCellPress @MRCBNDU @NDCNOxford Congrats! Very nice work

Our new paper shows #psilocybin has similar long-term antidepressant effects as the #SSRI escitalopram but leads to greater improvements in psychosocial functioning, connectedness, and life meaning. Published in Lancet @EClinMedicine. thelancet.com/journals/eclin… 🧵1/10

As part of #WorldAlzheimersMonth, we spoke to @marcaurelbusche, Group Leader at @UKDRI about his research, which he hopes will aid in the development of Alzheimer's disease treatments that are both safer and more effective: bit.ly/4cZWhes #UCLDementia

Understandably, a huge amount of research has focused on the role of SWRs in memory reactivation. However, increasing evidence argues that dentate spikes are another offline network event central to hippocampal population dynamics serving memory-guided behavior. (9/9)

Fourth, silencing dentate granule cells selectively during dentate spikes impairs subsequent performance in multi-object recognition tasks, highlighting the importance of neuronal activity during dentate spikes for memory. (8/9)

So, what did we find? First, we found that both SWR and dentate spike (DS) events significantly activated neurons in DG, CA3 and CA1, contrary to some reports that CA3 and CA1 neurons are suppressed during dentate spikes (5/9)

In adult mice, we recorded neuronal activity from three hippocampal regions – dentate gyrus, CA3 and CA1 as mice explored spatial environments and while they slept, which allowed us to see how these neurons respond during sharp-wave ripples (SWRs) and dentate spikes. (4/9)

One highly-studied mechanism enabling this coordination is the sharp-wave ripple (SWR), but here we studied a much less well-understood phenomenon, the dentate spike, a large amplitude signal seen in the dentate gyrus local field potential. (3/9)